Changes in musculus soleus strength response in alcoholic rats with experimentally induced 1 and 2 hours ischemia

Abstract

In the article there are highlighted the results of changes in musculus soleus strength response in alcoholic rats with experimentally induced ischemia duration of 1 and 2 hours duration. Experimental induction of ischemia was carried out, 30 days after the onset of chronic alcoholism, by squeezing the external iliac artery by the tourniquet. A strain gauge was used to record the change in the force of isometric contraction of the muscle. The results of our studies have shown that in alcoholic rats with experimentally induced ischemia with duration of 1 and 2 hours, there is a significant linear suppression of the contractile activity of skeletal muscles in different phases of the contraction process. Differences in the work of muscle, during the studied stages of contraction, can be explained by the difference in the processes of filaments interaction at the pretetanic and tetanic stages of contraction, and by the effect on these processes of changes in the connective tissue musculus membranes at the development of ischemic cascades due to effects of ethanol. That is, the violation of the contractile ability of skeletal muscles is revealed as a result of non-cholinergic effects of this pathology. Motor dysfunction of musculus soleus at alcoholic myopathy with experimentally induced ischemia will primarily be manifested when performing accurate positioned movements and correcting precise targeted changes in articular angles.