Clinical and Neuroimaging Changes in Ephedrine Abusers

Iu. Severyn V. N. Karazin Kharkiv National University

Abstract

The given article conserns the problem of homemade ephedrine drugs. It is shown that the use of these substances leads to serious changes in the brain by MRI data. The presence of Parkinson’s syndrome, pyramidal, cerebellar, oculomotor and autonomic disturbances, cognitive and depressive disorders during the neurological examination were revealed. Doctors shoul be alert to identify mentioned symptoms in young people conserning taking drug for the purpose of providing timely assistance and adequate correction of violations.

Downloads

Download data is not yet available.

References

Rokhlina M. L. Zloupotreblenie psikhostimulyatorami: psikhicheskie i povedencheskie rasstroystva [Abuse of stimulants: mental and behavioral disorders]. Voprosy narkologii, 2013, pp. 135-145. (In Russ.)

Skrypnikov A. M. Narkologija: navchal’no-metodychnyj posibnyk [Narcology: textbook]. Poltava, 2005, 427 p. (In Ukr.)

Sanotsky Y., Lesyk R., Fedoryshyn L. et al. Manganic Encephalopathy Due to “Ephedrone” Abuse. Movement Disorders, 2007, vol. 22, no. 9, pp. 1337-1342.

Danilin A. G. Kokain, pervitin i drugie psikhostimulyatory [Cocaine, methamphetamine and other psychostimulants]. Moscow, Tsentrpoligraf Publ., 2000, 282p. (In Russ.)

Mashkovskiy M. D. Lekarstvennye sredstva. Posobie dlya vrachey: v 2 t. [The medicaments. Manual for doctors: in 2 vol.]. Vilnius, 1993, vol. 1, 542 p. (In Russ.)

Fedorova N. V., Savchenko L. M., Ismailova T. F. i dr. Klinicheskie proyavleniya margantsevoy toksicheskoy entsefalopatii [Clinical manifestations of manganese toxic encephalopathy]. Ekstrapiramidni zahvorjuvannja ta vik: II Ukr.sympozium [Extrapyramidal disease and age: II Ukr.sympozium]. Kiev, IVC ALKON Publ., 2004, pp. 67-68. (In Russ.)

Yavorskaya V. A., Pelekhova O. L., Grebenyuk G. V., Krivchun S. A. Margantsevaya toksicheskaya entsefalopatiya: patogenez, klinika, lechenie [Marhantsevaya toksycheskaya encephalopathies: pathogenesis, clinic, treatment]. Mezhdunar. med. zhurn., 2005, no. 4, pp. 52-55. (In Russ.)

Kim Y., Kim J. W. Toxic Encephalopathy. Saf. Health. Work, 2012, no. 3, pp. 243-256.

Taytslin V. I., Voloshina N. P., Bogdanova I. V., FedoseevS.V. Miodistonicheskie narusheniya pri upotreblenii efedrinopodobnykh psikhostimulyatorov i ikh korrektsiya botulotoksinom [Myodystonic disorders when used efedrinopodobnyh stimulants and their correction with botulinum toxin]. Mezhdunar. med. zhurn., 2003, vol. 9, no. 4, pp. 41-43. (In Russ.)

Chang Y., Song H. J., Lee J. J. et al. Neuroplastic changes within the brains of manganese-exposed welders: recruiting additional neural resources for successful motor performance. Occup. Environ Med, 2010, vol. 67, pp. 809-815.

Dobbs M. R. Toxic encephalopathy. Semin. Neurol., 2011, vol. 31, pp. 184-193.

Chang Y., Lee J. J., Seo J. H. et al. Altered working memory process in the manganese-exposed brain. Neuroimage, 2010, vol. 53, pp. 1279-1285.

Kornienko V. N., Pronin I. N. Diagnosticheskaya neyroradiologiya [Diagnostic Neuroradiology]. 2009, vol. 3, 463 p. (In Russ.)

Kim Y., Jeong K. S. , Song H. J. Altered white matter microstructural integrity revealed by voxel-wise analysis of diffusion tensor imaging in welders with manganese exposure. Neurotoxicology, 2011, vol. 32, pp. 100-109.