KEY FACTORS OF PATHOGENESIS OF CHRONIC PANCREATITIS IN FAMILY DOCTOR’S PRACTICS
Анотація
During more than one hundred years of researching pathogenesis of chronic pancreatitis (CP) many of the hypothesis have been created. Some of them through time were denied, some were partly confirmed by results of clinical and experimental researchings and became hypothesis. However, not all the elements of pathogenesis of CP are clear till now. Probably, it is caused by large number of etiologic factors in development of CP, part of which have differences in pathogenesis. The hypothesis of 60s-70s of the last century were propounded and refuted exactly without taking into account these differences. The discoveries of the last 15 years, specifically determination of hereditary and autoimmune genesis of CP, have widened a notion of it’s pathogenesis. The majority of scientists consider a pathogenetic significance of the intraductal hypertension and intraductal protein and calcium precipitation. However, in opinion of some researchers, the mechanisms of its’ development are different. The fundamental pathophysiologic hypotheses of CP’s development, many of which are topical today, are considered in this article.
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Посилання
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6. Bernard J. Inhibition of nucleation and crystal growth of calcium carbonate by human lithostathine / J. Bernard, Z. Adrich, G. Montalto et al // Gastroenterology. – 2002. – Vol. 103. – P. 1277-1284.
7. Bimmler D. Pancreatic stone protein (lithostathine), a phy¬siologically relevant pancreatic calcium car-bonate crystal inhibitor? / D. Bimmler, R. Graf, G. Scheele [et al.] // J. Biol. Chem. – 2004. – Vol. 272. – P. 3073-3082.
8. Brady M. Cytokines and acute pancreatitis / M. Brady, S. Christmas, R. Sutton [et al.] // Ballieres. Best. Pract. Clin. Gastroenterol. – 2006. – Vol. 13. – P. 265-289.
9. De Coro A. Cha¬racterization of a protein isolated from pancreatic calculi of men suffering from chronic calcifying pancreatitis / A. De Coro, J. Lohse, H. Saries // Biochem. Biophys. Res. Commun. – 2001. – Vol. 87. – P. 1176-1182.
10. Sarles H., Bernard J.P. Lithostathine and pancreatic lithogenesis // Gastroenterol. Int. Ed. Int. – 2002. – Vol. 4. – P. 130-134.
11. Demols A. New frontiers in the pharmacological prevention of post-ERCP pancreatitis: The Cytokines /Deviere J.// JOP. J. Pan¬creas (Online). – 2003. – Vol. 4, N 1. – P. 49-57.
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17. Navarro S. Intra-abdominal pressure (iap) as an pre¬dictive factor of severity in acute pancreatitis / S. Navarro , J.M. Hidalgo, X. Bessa [et al.] // Gut. – 2003. – Vol. 52, suppl. 6. – P. Al 7.
18. Frossard J.L. Trypsin activation peptide (TAP) in acute pancreatitis: from patho-physiology to clinical usefulness // JOP. J. Pancreas (Online). – 2001. – Vol. 2, N 2. – P. 69-77.
19. Geokas M.C. Free proteolytic enzymes in pancreatic juice of patients with acute pancreatitis // Amer. J. Dig. Dis. – 2004. – Vol. 19. – P. 591-598.
20. Montalto G. Les inhibiteurs proteiques de cris¬tallisation. Caracterisation et role potentiel dans les lithiases calciques / G. Montalto, L. Multigner, H. Sarles, A. De Coro // Nephrologie. – 2004. – Vol. 5. – P. 155-157.
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22. Sarles H. Pathogenesis and epidemiology of chronic pancreatitis // Annu. Rev. Med. – 2004. -Vol.40. – P. 453.
23. Gough D.B. Free radical inhibition and serial chemilu-minescence in evolving experimental pancre¬atitis / D. B. Gough, B. Т. Boyle, W. P. Joyce [et al.] // Brit. J. Surg. – 2006. – Vol. 77. – P. 1256-1259.
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25. Lohse J. Calcium binding to the «stone proteins isolated from pancreatic stones of patients with chronic calcified pancreatitis / J. Lohse, R. Kraemer // Hoppe Seylers Z. Physiol. Chem. – 2000. – Vol. 365. – P. 549-554.
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28. Gerbaud V. Mechanism of calcite crystal growth inhibition by the N-terminal undecapeptide of lithostathine / V. Gerbaud, D. Pignol, E. Loret [et al.]//J. Biol. Chern. – 2000. -Vol. 275. – P. 1057-1064.
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35. Katsuzaki T. Enzyme immunoassay for specific analy¬sis of
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2. Opie E.L. The etiology of acute hemorrhagic pancreatitis // Bull. Johns Hopkins hosp. – 2001. – Vol. 12. – P. 182.
3. De Reggi M. Lithostathine, the presumed pancreatic stone inhibitor, does not interact specifi¬cally with calcium carbonate crystals / M. De Reggi, B. Gharib, L. Patard, V. Stoven // J. Biol. Chem. – 2004. – Vol. 273. – P. 4967-4971.
4. Жуков Н.О., Жукова О.М., Афанас’єва С.М. Клінічні форми хронічного рецидивуючого панкреа-титу і їх патогенетичні особливості /Актуальні проблеми терапії на рубежі століть: сб. науч. пр. – Омск, 2001. – С 54-58.
5. Braganza J.M. Evolution of pancreatitis // The pathogenesis of pancreatitis. – Manchester: Manchester University Press – 2005. – P. 19-33.
6. Bernard J. Inhibition of nucleation and crystal growth of calcium carbonate by human lithostathine / J. Bernard, Z. Adrich, G. Montalto et al // Gastroenterology. – 2002. – Vol. 103. – P. 1277-1284.
7. Bimmler D. Pancreatic stone protein (lithostathine), a phy¬siologically relevant pancreatic calcium car-bonate crystal inhibitor? / D. Bimmler, R. Graf, G. Scheele [et al.] // J. Biol. Chem. – 2004. – Vol. 272. – P. 3073-3082.
8. Brady M. Cytokines and acute pancreatitis / M. Brady, S. Christmas, R. Sutton [et al.] // Ballieres. Best. Pract. Clin. Gastroenterol. – 2006. – Vol. 13. – P. 265-289.
9. De Coro A. Cha¬racterization of a protein isolated from pancreatic calculi of men suffering from chronic calcifying pancreatitis / A. De Coro, J. Lohse, H. Saries // Biochem. Biophys. Res. Commun. – 2001. – Vol. 87. – P. 1176-1182.
10. Sarles H., Bernard J.P. Lithostathine and pancreatic lithogenesis // Gastroenterol. Int. Ed. Int. – 2002. – Vol. 4. – P. 130-134.
11. Demols A. New frontiers in the pharmacological prevention of post-ERCP pancreatitis: The Cytokines /Deviere J.// JOP. J. Pan¬creas (Online). – 2003. – Vol. 4, N 1. – P. 49-57.
12. Demols A. CD4(+)T cells play an important role in acute experimental pancreatitis in mice / A. Demols, O. Le Maine, F. Desalle [et al.] // Gastroenterology. – 2000. – Vol. 118. – P. 582-590.
13. Dunn J.A. Thera¬peutic modification of nuclear factor kappa B binding activity and tumor necrosis factor-alpha gene expression during acute biliary pancreatitis / J.A. Dunn, C. Li , T. Ha [et al.] // Amer. Surg. – 2007. – Vol. 63. – P. 1036-1043.
14. Жукова О.М. Роль депресії біоантиоксидантів і дефіциту інгібітору протеаз α1-антитрипсина в механізмі активації вільнорадикального окислення і протеоліза при хронічному панкреатиті / О.М. Жукова // Тер. арх. – 2000. – Т. 72, № 2. – С. 29-31.
15. Figarella C. Possibile lysosomal activation of pancreatic zymogens. Activation of both human trypsinogens by cathepsin B and spontaneous acid. Activation of human trypsinogen-1 / C. Figarella, B. Miszczuk-Jamska, A. Barrett // Biol. Chem. Hoppe-Seyler. – 2001. – Vol. 369. – P. 293-298.
16. Tanaka T. Pancreatic duct obstruction is an aggravating factor in the canine model of chronic alcoholic pancreatitis / T. Tanaka, Y. Miura, Y. Matsugu [et al.] // Gastroenterology. – 2003. – Vol. 115.- P. 1248 -1253.
17. Navarro S. Intra-abdominal pressure (iap) as an pre¬dictive factor of severity in acute pancreatitis / S. Navarro , J.M. Hidalgo, X. Bessa [et al.] // Gut. – 2003. – Vol. 52, suppl. 6. – P. Al 7.
18. Frossard J.L. Trypsin activation peptide (TAP) in acute pancreatitis: from patho-physiology to clinical usefulness // JOP. J. Pancreas (Online). – 2001. – Vol. 2, N 2. – P. 69-77.
19. Geokas M.C. Free proteolytic enzymes in pancreatic juice of patients with acute pancreatitis // Amer. J. Dig. Dis. – 2004. – Vol. 19. – P. 591-598.
20. Montalto G. Les inhibiteurs proteiques de cris¬tallisation. Caracterisation et role potentiel dans les lithiases calciques / G. Montalto, L. Multigner, H. Sarles, A. De Coro // Nephrologie. – 2004. – Vol. 5. – P. 155-157.
21. Gloor B. Kupffer cell blockade reduces hepatic and systemic cytokine levels and lung injury in hemorrhagic pancreatitis in rats / B. Gloor, T. A. Blinman, D. A. Rigberg [et al.] // Pancreas. – 2000. – Vol. 21. – P. 414-420.
22. Sarles H. Pathogenesis and epidemiology of chronic pancreatitis // Annu. Rev. Med. – 2004. -Vol.40. – P. 453.
23. Gough D.B. Free radical inhibition and serial chemilu-minescence in evolving experimental pancre¬atitis / D. B. Gough, B. Т. Boyle, W. P. Joyce [et al.] // Brit. J. Surg. – 2006. – Vol. 77. – P. 1256-1259.
24. Graf R. A family of 16-kDa pancreatic secretory stress proteins form highly organized fibrillar structures upon tryptic activation / R. Graf, M. Schiesser, G. Scheele [et al.] // J. Biol. Chem. – 2005. – Vol. 276. – P. 2128-2138.
25. Lohse J. Calcium binding to the «stone proteins isolated from pancreatic stones of patients with chronic calcified pancreatitis / J. Lohse, R. Kraemer // Hoppe Seylers Z. Physiol. Chem. – 2000. – Vol. 365. – P. 549-554.
26. Mariani A. Differences of pancreatic stone morphology and content in patients with pancreatic lithiasis / A. Mariani, J. Bernard, M. Provansal-Cheylan [et al.] // Dig. Dis. Sci. – 2001. – Vol. 36. – P. 1509-1516.
27. Multigner L. Pancreatic stone protein, a phosphoprotein which inhibits calcium carbonate precipitation from human pancreatic juice / L. Multigner, A. De Caro, D. Lombardo [et al.] // Biochem. Biophys. Res. Commun. – 2003. – Vol. 110.- P. 69-74.
28. Gerbaud V. Mechanism of calcite crystal growth inhibition by the N-terminal undecapeptide of lithostathine / V. Gerbaud, D. Pignol, E. Loret [et al.]//J. Biol. Chern. – 2000. -Vol. 275. – P. 1057-1064.
29. Gukovsky I. Early NF-kappa B activalion is associated with hormone-induced pancreatitis / I. Gukovsky, A. Gukovskaya, T. Blinman [et al.] // Amer. J. Physiol. – 2008. – Vol. 275. – P. 1402-1414.
30. Guy O. Protein content If precipitates present in pancreatic juice of alcoholic subjects and patients with chronic calcifying pancreatitis / O. Guy, G. Robles-Diaz, Z. Aldrich [et al.] // Gastroenterology. – 2002. – Vol. 84. – P. 102-107.
31. Hoyakawa T. Trypsinogen content of pancreatic calculi in chronic calcified pancreatitis in man / T. Hoyakawa, T. Kondo, T. Shibata [et al.] // Dig. Dis. Sci. – 2004. – Vol. 39. – P. 1345-1350.
32. Hietaranta A.J. Relationship between NF-kappa B and trypsinogen activation in rat pancreas after supramaximal caerulein stimulation / A. J. Hietaranta, A. X. Saluja, L. Bhagat [et al.] // Biochem. Biophys. Res. Commun. – 2005. – Vol. 280. – P. 388-395,
33. Hofbauer B. Intra-acinar cell activation of trypsinogen during cerulein-induced pancreatitis in rats / B. Hofbauer, A. Saluja, M. Lerch [et al.] // Amer. J. Physiol. – 2006. – Vol. 275. – P. 352-362.
34. Jin C. X. Pancreatic stone protein of pancreatic calculi in chronic calcified pancreatitis in man / C. X. Jin, S. Naruse, M. Kitagawa [et al.] // JOP. J. Pancreas (Online). – 2007. – Vol. 3, N 2. – P. 54-61.
35. Katsuzaki T. Enzyme immunoassay for specific analy¬sis of
pancreatic stone ptroteins in human pan-creatic juice / T. Katsuzaki, N. Tatemichi, C. Takeichi [et al.] // J. Clin. Lab. Anal. – 2001. – Vol. 6. – P. 375-378.
36. Koepell G. Pseudocysts in chronic pancreatitis: a morphological analysis of 57 resection specimens and 9 autopsy pancreata / G. Koepell, B. Maillet // Pancreas. – 2007. – Vol. 6. – P. 266-274.
37. Koike H. Pan¬creatic effects of ethionine: blockade of exocytosis and appearance of crinophagy and autophagy precede cellular necrosis / H. Koike, M. Steer, J. Meldolesi // Amer. J. Physiol. – 2000. – Vol. 242. – P. 297-307.
38. Lerch M.M. Pancreatic duct obstruction triggers acute necrotizing pancreatitis in opossum / M. M. Lerch, A. K. Saluja, M. Runzi [et al.] // Gastroenterology. – 2002. – Vol. 104. – P. 853-861.
39. Miszczuk-Janska B. Alfa 1-Proteinase inhibitor in pure human pancreatic juice. Characterization of a com¬plexes form in patients with chronic calcifying pancreatitis and its significance / B. Miszczuk-Janska, O. Guy, C. Figarella // Hoppe Seylers Z. Physiol. Chem. – 2003. – Vol. 364. – P. 1597-1601.
40. Muller J.M. Study of gene regulation by NF-kappa B and AP-1 in response to reactive oxygen interme-diates / J. M. Muller, R. A. Rupee, P. A. Baeuerle // Methods. – 2007. – Vol. 11. – P. 301-312.
41. Multigner L. Radiolucent pancrea¬tic stones // New Engl. J. Med. – 2006. – Vol. 314. – P. 248.
42. Multigner L. Pancreatic stone protein. I. Implications in stone formation during the course of chronic pancreatitis / L. Multigner Sorles, H. Lombardo, A. DeCoro // Gastroenterology. – 2005. – Vol. 89. – P. 381.
43. Pap A., Boros L. Alcohol-induced chronic pancreatitis in rats after temporary occlusion of biliopancreatic ducts with ethi-bloc // Pancreas. – 2002. – Vol. 4. – P. 249 – 255.
44. Patard L. An insight into the role of human pancreatic lithostathine / L. Patard, J.-Y. Lallemand, V. Stoven // JOP. J. Pancreas (Online). – 2003. – Vol. 4, N 2. – P. 92 – 103.
45. Figarella C. Alkaline phosphatase and acid lysosomal hydrolases in pancreatic juice and fibroblast cell cultures of patients with chronic calcifying pancreatitis / C. Figarella, E.Vogt, P. Hosli // Europ. J. Clin. Invest. – 2003. – Vol. 12. – P. 145-149.
46. Pfutzer R. SPINK1 /PSTI polymorphisms act as a dise¬ase modifiers in familial and idiopathic chron¬ic pancreatitis // Gastroenterology. – 2000. – Vol. 19. – P. 615 – 623.
47. Pitchumoni C.S. Infrastructure and elemental composition of human pancre¬atic calculi / C.S. Pitchumoni, K.V. Viswanathan, P.J. Gee, P.A. Varghese Banks // Pancreas. – 2007. – Vol. 2. – P. 152 – 158.
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Як цитувати
Vovk, K., Sokruto, O., Nikolenko, J., & Savchenko, V. (1). KEY FACTORS OF PATHOGENESIS OF CHRONIC PANCREATITIS IN FAMILY DOCTOR’S PRACTICS. Вісник Харківського національного університету імені В. Н. Каразіна. Серія «Медицина», (18), 49-58. вилучено із https://periodicals.karazin.ua/medicine/article/view/6956
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Вісник Харківського національного університету імені В. Н. Каразіна, серія Медицина має такі умови авторського права:
1. Автори зберігають авторські права та надають журналу право на першу публікацію разом із роботою, яка одночасно ліцензується згідно з ліцензією Creative Commons Attribution License, яка дозволяє іншим ділитися роботою з визнанням авторства роботи та першої публікації в цьому журналі.
2. Автори можуть укладати окремі додаткові договірні угоди щодо неексклюзивного розповсюдження опублікованої журналом версії роботи з підтвердженням її початкової публікації в цьому журналі.
3. Авторам дозволяється та заохочується публікувати свої роботи в Інтернеті до та під час процесу подання, оскільки це може призвести до продуктивного обміну, а також до раннього та більшого цитування опублікованої роботи.
