THE EFFECT OF EARLY POSTNATAL OVERNUTRITION ON PROOXIDANT-ANTIOXIDANT BALANCE AND NO-SYNTHASE ACTIVITY IN OLD RATS TISSUES

  • Yu.V. Nikitchenko
  • V.N. Dzyuba
  • А.S. Popovich
  • А.А. Sheremet
  • V.V. Bondar
Keywords: overnutrition, prooxidant-antioxidant balance, thyroid status, NO-synthase activity, rats

Abstract

The peculiarities of changes of prooxidant-antioxidant balance, thyroid status and NO-synthase activity in tissues of 20-month-old rats after overnutrition during first month after birth were investigated. It was found out that body weight, thyroxine concentration, lipid hydroperoxides content and NO-synthase activity in experimental rats were higher than in control ones. At the same time Se-dependent glutathione peroxidase activity was significantly decreased in liver of experimental rats. It is assumed that prooxidant-antioxidant system and thyroid state may be ones of the key links of the mechanism determining rats surviving in conditions of overnutrition.

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How to Cite
Nikitchenko, Y., Dzyuba, V., PopovichА., SheremetА., & Bondar, V. (1). THE EFFECT OF EARLY POSTNATAL OVERNUTRITION ON PROOXIDANT-ANTIOXIDANT BALANCE AND NO-SYNTHASE ACTIVITY IN OLD RATS TISSUES. The Journal of V. N. Karazin Kharkiv National University, Series "Medicine", (19), 12-16. Retrieved from https://periodicals.karazin.ua/medicine/article/view/6930
Section
Fundamental research