ISCHEMIA EFFECT ON ATPASE ACTIVITY OF HEART MITOCHONDRIA IN YOUNG AND OLD RATS

  • V.N. Dzuba
  • Yu.V. Nikitchenko
  • T.A. Shmonina

Abstract

ATPase activity alterations in rats of different age groups during the total myocardial ischemia were studied. It was determined that only mitochondrial oligomycin-sensitive ATPase was sensitive to effect of the total myocardial ischemia. The fact that addition of magnesium ions in the incubation medium eliminated ischemic effect in 3-months old rats and weakened it in 24-months old rats pointed to important role of magnesium ions in structure-functional reconstruction of mitochondria under myocardial ischemia. Young 3months old rats were established to be more tolerant to myocardial ischemic damage thanold animals.

Downloads

Download data is not yet available.
How to Cite
Dzuba, V., Nikitchenko, Y., & Shmonina, T. (1). ISCHEMIA EFFECT ON ATPASE ACTIVITY OF HEART MITOCHONDRIA IN YOUNG AND OLD RATS. The Journal of V. N. Karazin Kharkiv National University, Series "Medicine", (1), 25-29. Retrieved from https://periodicals.karazin.ua/medicine/article/view/7450
Issue
No. 1 (2000)
Section
Fundamental research

The Journal of V. N. Karazin Kharkiv National University, series Medicine has following copyright terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work’s authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal’s published version of the work, with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.