CORRECTION BY BIOPOLYMER FROM RAPANA TISSUES THE CHANGE OF PROOXIDANT-ANTIOXIDANT BALANCE STATE OF RAT ORGANISM UNDER UNBALANCED NUTRITION

  • Yu.V. Nikitchenko
  • V.N. Dzyuba
  • Т.N. Оvsyannikova
  • О.Ye. Bityutskaya
  • V.V. Bondar
  • А.А. Sheremet
  • А.S. Popovich
Keywords: prooxidant-antioxidant balance, unbalanced nutrition, biopolymer from rapana tissues, rats

Abstract

The peculiarities of change of prooxidant-antioxidant balance in rat hepatocytes and blood serum under unbalanced nutrition and possibilities of its correction by means of supplement of ration by food addition (biopolymer from rapana tissues (BR)) were investigated. It was found out that the used food addition in conditions in vitro had revealed significant antiradical activity. It is shown that the use of BR against the background of unbalanced ration led to normalization of lipid hydroperoxides content in blood and significant decrease of the level of these LPO products in rat hepatocytes, to the slowing of glutathione peroxidase activity decrease in hepatocytes and normalization of superoxide dismutase activity in blood of experimental animals. 

Downloads

Download data is not yet available.

References

1. Tkachenko V., Nikitchenko Y., Tovstiak V. // Annales Universitatis Mariae Curie-Sklodowska, Lublin-Polonia. - 2004. - Vol. XVII. - № 2. - P. 289-291.

2. Никитченко Ю.В., Падалко В.И., др. // Радиац. Биол. Радиоэкология.- 2008. - Т.48, №2. -С.171-176.

3. Ткаченко В.М., Нікітченко Ю.В., Товстяк В.В. // Біологія тварин. - 2004. - Т.6, № 1-2. - С. 196-202.

4. Декларац. пат. 60504 UA, А 7 А61К35/36. Біополімер з тканин молюсків, спосіб його виділення та біологічні властивості: О.Є. Бітютська, Т.М. Овсянникова, А.Г. Губанова та ін. (Україна). - № 2002108573; Заявл. 29.10.02; Опубл. 15.10.03, Бюл. № 10. - 9 с.

5. Kravchenko L., Petrenko A., Fuller B. // Cell Biol. Int. - 2002. - Vol. 26. - P. 1003-1006.

6. Ohkawa H., Ohahi N., Jadi K. // Anal. Biochem. - 1979. - Vol. 95. - № 2. - P. 351-358.

7. Asakawa T., Matsushita S. // Lipids. - 1980. - Vol. 15. - № 3. - P. 137-140.

8. Flercher B.L., Dillard C.J., Tappel A.Y. // Anal. Biochem. - 1973. - Vol. 52. - P. 1-9.

9. Клебанов Г.И., Бабенкова И.В., Теселкин Ю.О. и др. // Лаб. дело. - 1988. - № 5. - С. 59-62.

10. Halliwell B., Gutteridge J.M.C., Aruoma O.I. // Anal. Biochem. - 1987. - Vol. 165. - № 1. - P. 215-219.

11. Beavchamp C., Fridovich I. // Anal. Biochem. - 1971. - Vol. 44. - № 1. - P. 276-287.

12. Ravin H.A. // Lancet. - 1956. - Vol. 1. - P. 7267-7271.

13. Paglia D.E., Valentine W.N. // J. Lab. Clin. Med. - 1967. - Vol. 70. - P. 158-169.

14. Younes M., Schlichting R., Siegers C.P. // Pharmacol. Res. Communs.- 1980.-Vol.2.- № 2. - P. 115-128.

15. Герасимов А.М., Королева Л.А., Брусев А.С. и др. // Вопр. мед. химии.- 1976.-Т.22, № 1. - C. 89-94.

16. Прооксидантно-антиоксидантний баланс та структурно-функціональний стан біомембран при застосуванні незбалансованих дієт: Звіт про НДР / НДІ біології Харківського національного університету імені В.Н. Каразіна. - № ДР 0106U001581. - Х., 2006. - 37 с.
How to Cite
Nikitchenko, Y., Dzyuba, V., ОvsyannikovaТ., BityutskayaО., Bondar, V., SheremetА., & PopovichА. (1). CORRECTION BY BIOPOLYMER FROM RAPANA TISSUES THE CHANGE OF PROOXIDANT-ANTIOXIDANT BALANCE STATE OF RAT ORGANISM UNDER UNBALANCED NUTRITION. The Journal of V. N. Karazin Kharkiv National University, Series "Medicine", (16), 13-17. Retrieved from https://periodicals.karazin.ua/medicine/article/view/6976
Issue
No. 16 (2008)
Section
Fundamental research

The Journal of V. N. Karazin Kharkiv National University, series Medicine has following copyright terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work’s authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal’s published version of the work, with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.