• O. V. Petyunina Government institution «L. T. Malaya Therapy National Institute of the National Academy of medical science of Ukraine»
Keywords: anxiety-depressive disorders, STEMI patients, sST2, myocardial remodeling


Depression after AMI increases the frequency of re-hospitalization because of acute coronary syndrome, heart failure, MI, and is a risk factor for cardiac arrest and death. The objective of the study was to define the influence of anxiety-depressive disorders (ADD) on afterinfarction remodeling and the participation of sST2 fibrosis factor in this process. 100 STEMI patients were enrolled to the study, 81 (81 %) male and 29 (29 %) female, of average age of 58,94 ± 10,16 years. Examinations were performed twice: during 1–3 days after PCI with infarct-related artery stenting and included clinical-anamnesis data, blood analyses. The sST2 level was defined by immune-fermentative method with usage of «Presage ST2 Assay», Critical Diagnostics, USA. For ADD objectivization, HADS (Heart Anxiety and Depression Scale) and Teylor questionary were used. In 6 month 6-minute walk test and the volume fraction of interstitial collagen (VFIC) were done. Conclusion: ADD in patients with STEMI aggravates the course of postinfarction period and entails the progression of fibrotic-hypertrophic processes and corresponding remodeling of myocardium, decrease of physical tolerance.


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Author Biography

O. V. Petyunina, Government institution «L. T. Malaya Therapy National Institute of the National Academy of medical science of Ukraine»

Prospect Lyubov Maloy, 2A, Kharkiv, 61000, Ukraine


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How to Cite
Petyunina, O. V. (2017). THE INFLUENCE OF ANXIETY AND DEPRESSIVE CONDITIONS ON AFTERINFARCTION REMODELING IN PATIENTS WITH STEMI. The Journal of V. N. Karazin Kharkiv National University, Series "Medicine", (33), 27-33. Retrieved from
Clinical research