THE ROLE OF A NEW BIOMARKER GROWTH DIFFERENTIATION FACTOR 15 IN PROGNOSIS OF PATIENTS WITH ACUTE CORONARY SYNDROME AND TYPE 2 DIABETES MELLITUS

  • M. P. Kopytsya GI «L. T. Malaya Therapy National Institute of the National Academy of medical science of Ukraine», Kharkov, Ukraine
  • O. V. Petyunina Government institution «L. T. Malaya Therapy National Institute of the National Academy of medical science of Ukraine»
  • I. R. Vyshnevska Government institution «L. T. Malaya Therapy National Institute of the National Academy of medical science of Ukraine»
  • N. V. Tytarenko Government institution «L. T. Malaya Therapy National Institute of the National Academy of medical science of Ukraine»
  • Y. V. Hilova Government institution «L. T. Malaya Therapy National Institute of the National Academy of medical science of Ukraine»
DOI: https://doi.org/10.26565/2227-6505-2016-32-02
Keywords: biomarkers, GDF 15, diabetes mellitus, acute coronary syndrome, prognosis

Abstract

Numerous studies confirm worse results in diabetic patients with acute coronary syndrome (ACS) compared with non-diabetic patients. Different mechanisms underlie the adverse outcomes of ACS and diabetes mellitus. In this connection, a special place is occupied by the study of new biomarkers that reflect the complex pathogenic processes in these patients. Purpose: to investigate the role of the biomarker GDF 15 in prognosis of adverse outcomes in type 2 diabetes mellitus (DM2T) patients with ACS. Materials and methods: 73 patients with different forms of ACS were screened. Levels of biomarkers: GDF 15, N-terminal pro brain natriuretic peptide (NT-pro BNP) and C-reactive protein (C-RP) were determined. The follow up period was 1 year. Endpoint was defined as lethal outcome. Results: significant differences in GDF 15 level has been found, prognostic value of GDF 15 was estimated in patients with DM2T, using a ROC-analysis. Threshold level of GDF 15 has been determined as 3894 pg/ml, with sensitivity of 64 % and specificity of 75 %. Conclusion: Patients with ACS and DM2T more often had a history of different cardiovascular diseases and risk factors compared to patients without diabetes. GDF 15 level was significantly higher in patients with ACS who had history of DM2T.

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Author Biographies

M. P. Kopytsya, GI «L. T. Malaya Therapy National Institute of the National Academy of medical science of Ukraine», Kharkov, Ukraine

Prospect Lyubov Malyoy, 2A, Kharkiv, Kharkiv region, 61000

O. V. Petyunina, Government institution «L. T. Malaya Therapy National Institute of the National Academy of medical science of Ukraine»

Prospect Lyubov Malyoy, 2A, Kharkiv, Kharkiv region, 61000

I. R. Vyshnevska, Government institution «L. T. Malaya Therapy National Institute of the National Academy of medical science of Ukraine»

Prospect Lyubov Malyoy, 2A, Kharkiv, Kharkiv region, 61000

N. V. Tytarenko, Government institution «L. T. Malaya Therapy National Institute of the National Academy of medical science of Ukraine»

Prospect Lyubov Malyoy, 2A, Kharkiv, Kharkiv region, 61000

Y. V. Hilova, Government institution «L. T. Malaya Therapy National Institute of the National Academy of medical science of Ukraine»

Prospect Lyubov Malyoy, 2A, Kharkiv, Kharkiv region, 61000

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How to Cite
Kopytsya, M. P., Petyunina, O. V., Vyshnevska, I. R., Tytarenko, N. V., & Hilova, Y. V. (1). THE ROLE OF A NEW BIOMARKER GROWTH DIFFERENTIATION FACTOR 15 IN PROGNOSIS OF PATIENTS WITH ACUTE CORONARY SYNDROME AND TYPE 2 DIABETES MELLITUS. The Journal of V. N. Karazin Kharkiv National University, Series "Medicine", (32), 12-18. https://doi.org/10.26565/2227-6505-2016-32-02
Issue
No. 32 (2016): The Journal of V. N. Karazin Kharkiv National University. Series "Medicine"
Section
Clinical research

Copyright (c) 2017 M. P. Kopytsya, O. V. Petyunina, I. R. Vyshnevska, N. V. Tytarenko, Y. V. Hilova

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