ALLELE STATUS OF ALDOSTERONE SYNTHASE (CYP11B2) GENE POLYMORPHISM AND CARDIAC REMODELING AFTER ST SEGMENT ELEVATION MYOCARDIAL INFARCTION

  • O. V. Petyunina Government institution «L. T. Malaya Therapy National Institute of the National Academy of medical science of Ukraine» https://orcid.org/0000-0002-4716-6433
  • M. P. Kopytsya Government institution «L. T. Malaya Therapy National Institute of the National Academy of medical science of Ukraine»
  • I. R. Vyshnevska Government institution «L. T. Malaya Therapy National Institute of the National Academy of medical science of Ukraine»
Keywords: STEMI, CYP11B2 gene polymorphism, cardiac remodeling

Abstract

Aldosterone plays an important role in the development of reparative and reactive fibrosis and cardiac remodeling (CR) after myocardial infarction. The objective of the study is to investigate the structural and functional parameters of the myocardium, heart rate variability (HRV), exercise intolerance, levels of sST2 in association with polymorphism of CYP11B2 gene of aldosterone-synthase in ST-myocardial infarction (STEMI) patients during a 6-months follow-up period. 85 STEMI patients were enrolled: 68 (80 %) male and 17 (20 %) female, mean age was 58,94 ± 10,16 years. Examinations were performed twice: during 1–3 days after PCI with infarct-related artery stenting and included clinical assessment, ultrasound diagnostic, immunofermentative blood analyses (sST2), polymerase chain reaction in real time (polymorphism –T344C of the CYP11B2 gene). After 6-months of observation, 57 patients were reexamined – clinical assessment, ultrasound diagnostic, HRV were performed. CYP11B2 TT-genotype in 6 months after STEMI is associated with a maladaptive character of after infarction remodeling.

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Author Biographies

O. V. Petyunina, Government institution «L. T. Malaya Therapy National Institute of the National Academy of medical science of Ukraine»

проспект Любові Малої, 2А, Харків, 61000, Україна

M. P. Kopytsya, Government institution «L. T. Malaya Therapy National Institute of the National Academy of medical science of Ukraine»

проспект Любові Малої, 2А, Харків, Харківська область, 61000

I. R. Vyshnevska, Government institution «L. T. Malaya Therapy National Institute of the National Academy of medical science of Ukraine»

проспект Любові Малої, 2А, Харків, Харківська область, 61000

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Published
2017-12-28
How to Cite
Petyunina, O. V., Kopytsya, M. P., & Vyshnevska, I. R. (2017). ALLELE STATUS OF ALDOSTERONE SYNTHASE (CYP11B2) GENE POLYMORPHISM AND CARDIAC REMODELING AFTER ST SEGMENT ELEVATION MYOCARDIAL INFARCTION. The Journal of V. N. Karazin Kharkiv National University, Series "Medicine", (34), 27-35. https://doi.org/10.26565/2227-6505-2017-34-05