Вплив міцелярного середовища на протолітичні рівноваги домперідону
Анотація
В міцелярному середовищі додецилсульфату натрію та цетилпіридиній хлориду методами рН-метричного титрування та спектрофотометрії спробувано визначити константи депротонування бензімідазолонових фрагментів нейтральної форми домперідону. Встановлено, що домперідон нестійкий у лужному середовищі в присутності міцел поверхнево-активних речовин. Запропоновано схему лужного гідролізу домперідону в міцелярному середовищі іоногенних поверхнево-активних речовин.
Завантаження
Посилання
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