Hydration changes under complexation of dna with some intercalators
Keywords:
DNA, hydration, complex, ethidium bromide, proflavine, propidium iodide, dielectric permittivityAbstract
The dielectric properties of water solutions of some intercalators (ethidium bromide, proflavine, propidium iodide) and complexes of DNA with these substances were investigated in the range of millimeter wavelengths. The extent of hydration and probable hydration-active centers were determined for ligands studied. It was found that the complexation is accompanied by changes in the dielectric properties of solutions induced by changes in the hydration shell of DNA. It is shown that the observed decrease of dielectric permittivity corresponds to the notable increase of DNA hydration. The obtained results are compared with known data and are analyzed using the models for interaction between DNA and
intercalators.
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