Platelet aggregation assays at different temperatures
Keywords:
platelet aggregation, temperature, light transmission aggregometry, temperature controlAbstract
In this paper, we describe thermomechanical changes in the standard instrument for the study of platelet
aggregation, which allow studying platelet function at temperatures different from ambient temperature.
Application of advanced aggregometer enables measurement of induced platelet aggregation at a
temperature range from 4 to 40 °C and use of the temperature dependence of aggregation data to intepret
mechanisms of platelet thermophysilogy. Perspectives and relevance of this approach for further inquiry
of platelet function at different temperatures is discussed particulrly pertaining to blood transfusion
practices and study of certain clinical situations.
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