The possible role of the single-chain largeness damages in the formation of lethal DNA double-chain scissions in cells exposed to X-radiation or gamma-radiation

Authors

  • V. G. Knigavko Харьковский государственный медицинский университет Author
  • O. P. Meshcheryakova Kharkiv State Medical University Author
  • E. B. Radzichevckaya S. P. Grigoriev Institute of Medical Radiology Author

Keywords:

double-chain scissions DNA, single-chain damages, X-radiation, gamma-radiation

Abstract

In paper we have propound the origination radiation damage that could be hardly repaired or non-repaired as a result of the transformation single-chain largeness gaps into double-chain scissions in the DNA of the irradiated cells. It became the basis for the mathematical modelling of the single-chain largeness gaps formation and theirs transformation into the double-chain scissions. By virtue of the constructed model the formulas for calculating the mean number of single-chain largeness gaps and double-chain scissions at the cell were obtained.

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Author Biographies

  • V. G. Knigavko, Харьковский государственный медицинский университет

     4 Lenin av., Kharkiv, Ukraine

  • O. P. Meshcheryakova, Kharkiv State Medical University

     4 Lenin av., Kharkiv, Ukraine

  • E. B. Radzichevckaya, S. P. Grigoriev Institute of Medical Radiology

    82 Pushkinskaya St., 61024 Kharkov, Ukraine

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Published

2018-06-25

Issue

Vol. 2 No. 13 (2003): Біофізичний вісник

Section

Biophysics of complex systems

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How to Cite

The possible role of the single-chain largeness damages in the formation of lethal DNA double-chain scissions in cells exposed to X-radiation or gamma-radiation. (2018). Biophysical Bulletin, 2(13), 82-85. https://periodicals.karazin.ua/biophysvisnyk/article/view/12441

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