Neuroplasticity And Cognitive Impairment In Patients With Bipolar Depression

Valerii Pidkorytov State Institution "Institute of Neurology, Psychiatry and Narcology of National Academy of Medical Science of Ukraine"
Olga Syerikova State Institution "Institute of Neurology, Psychiatry and Narcology of National Academy of Medical Science of Ukraine", Kharkiv
Olga Skrynnyk State Institution "Institute of Neurology, Psychiatry and Narcology of National Academy of Medical Science of Ukraine", Kharkiv
Sergiy Ukrayinskyy State Institution "Institute of Neurology, Psychiatry and Narcology of National Academy of Medical Science of Ukraine", Kharkiv
Yurii Buchok State Higher Educational Institution "Uzhhorod National University of Ministry of Education and Science of Ukraine", Uzhhorod
Sergii Kyryluik Danylo Halytsky Lviv National Medical University, Lviv

Abstract

The pathogenesis of affective disorders has a complex multi-level character. In recent studies it was proved that in the depressive phase of bipolar affective disorder (BAD) there are observed violations of neuronal plasticity and macromorphological changes in brain regions that are responsible for cognitive functions. So, there is a close connection between the morphological and functional disorders in the marked areas and consequences of cognitive disorders in patients with BAD, such as impaired memory, attention and other things. Thus, improving neuroplasticity, we can indirectly affect depressive symptoms. The joint prescription of antidepressants and drugs that can directly improve metabolic processes in brain is promising in this respect. During the research we studied the approach to treatment of patients with depressive episode of BAR. It is proved that the use of pharmaceuticals which affect the brain’s neuroplasticity in patients with depressive phase of BAD significantly increases the efficiency of treatment and enlarges doctor’s therapeutic arsenal.

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Author Biographies

Valerii Pidkorytov, State Institution "Institute of Neurology, Psychiatry and Narcology of National Academy of Medical Science of Ukraine"

Doctor of Sciences in Medicine, Professor, Head of Department

Olga Syerikova, State Institution "Institute of Neurology, Psychiatry and Narcology of National Academy of Medical Science of Ukraine", Kharkiv

PhD in Medicine, Leading Scientific Researche

Olga Skrynnyk, State Institution "Institute of Neurology, Psychiatry and Narcology of National Academy of Medical Science of Ukraine", Kharkiv

PhD in Medicine, Senior Scientific Researcher

Sergiy Ukrayinskyy, State Institution "Institute of Neurology, Psychiatry and Narcology of National Academy of Medical Science of Ukraine", Kharkiv

PhD in Medicine, Senior Scientific Researcher

Yurii Buchok, State Higher Educational Institution "Uzhhorod National University of Ministry of Education and Science of Ukraine", Uzhhorod

PhD in Medicine, Associate Professor

Sergii Kyryluik, Danylo Halytsky Lviv National Medical University, Lviv

PhD in Psychiatry, Associate Professor

References

The World health report : 2001: Mental health : new understanding, new hope. – 2001. – 178 p.

Хобзей М. К. Состояние психического здоровья населения и перспективы развития психиатрической помощи в Украине / М. К. Хобзей, П. В. Волошин, Н. О. Марута, О. М. Инченко, О. О. Петриченко, Л. И. Дьяченко // Психическое здоровье. – 2013. – Т.11, No 7 (86). – С. 66–76.

Подкорытов В. С. Депрессии. Современная терапия: руководство для врачей / В. С. Подкорытов, Ю. Ю. Чайка. – Х. : Торнадо, 2003. – С.20.

Stahnisch F. W.Сoncept of neuronal plasticity: the ambiguity lives on / F. W. Stahnisch, R. Nitsch, Santiago Ramоn у Cajal’s // Trends Neurosci. – 2002. – Vol. 25, No 11. – P. 589 – 591.

Zilles K. Neuronal plasticity as an adaptive property of the central nervous system / K. Zilles // An. Anat. – 1992. – Vol. 174, No 5. – P. 383–391.

Pittenger C. Disorders of memory and plasticity in psychiatric disease / C. Pittenger // Dialogues Clin. Neurosci. – 2013. – Vol. 15, No 4. – P. 455–463.

Spalding K. L. Dynamics of hippocampal neurogenesis in adult humans / K. L. Spalding , O. Berg-mann, K. Alkass et al. // Cell. – 2013. – Vol. 153, No 6. – P. 1219–1227.

Sairanen M. Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects Von neuronal turnover, proliferation, and survival in the adult dentate gyrus / M. Sairanen, G. Lucas, P. Ernfors et al. // J. Neurosci. – 2005. – Vol. 25, No 5. – P. 1089–1094.

Martinez A. TrkB and TrkC signaling are required for maturation and synaptogenesis of hippocampal connections / A. Martinez, S. Alcantara, V. Borrell [et al.] // J. Neurosci. – 1998. – Vol. 18, No 18. – P. 7336–7350.

Doron R. A novel herbal treatment reduces depressive-like behaviors and increases BDNF levels in the brain of stressed mice / R. Doron, D. Lotan, N. Einat [et al.] // Life Sci. – 2014. – Vol. 94, N 2. – P. 151 – 157.

Dwivedi Y. Brain-derived neurotrophic factor: role in depression and suicide / Y. Dwivedi // Neuropsy-chiatr. Dis. Treat. – 2009. – Vol. 5. – P. 433–449. 12. Bondy B. Pathophysiology of depression / B. Bondy // Dialogues in clinical neuroscience. – 2002. – Vol. 4, No 1 – P. 7–20.

Shakesby A. C. Overcoming the effects of stress on synaptic plasticity in the intact hippocampus: rapid actions of serotonergic and antidepressant agents. A. C. Shakesby [et al.] // J. Neurosci. – 2002. – Vol. 22. – P. 638–44.

Wayne D. C. Neuroplasticity in mood disorders / D. C. Wayne // Dialogues in clinical neuroscience. Neu-roplasticity. – 2004. – No 6. – P. 199–216.

Vaidya V. A. Role of 5-HT2A receptors in the down regulation of BDNF by stress / V. A. Vai dya , R. Z. Terwilliger, R. S. Duman Neurosci Lett. – 1999. – Vol. 287. – P. 1–4.

Fuchs E. Mini-review: in vivo neurogenesis in the adult brain, regulation and functional implications / E. Fuchs, E. Gould // Eur J Neurosci. – 2000. – Vol. 12. – P. 2211–2214.

Fuchs T. The challenge of neuroscience: Psychiatry and phenomenology today / T. Fuchs // Psycho-pathology. – Vol. 35. – Р. 319–326.

Гусев Е. И. Роль процессов нейропластичности в развитии депрессивных расстройств / Е. И. Гусев, А. Н. Боголепова // Трудный пациент. – 2010. – Т. 8, No 10. – С. 3–7.

Steffens D. C. Subcortical white matter lesions and functional impairment in geriatric depression / D. C. Steffens, H. B. Bosworth, J. M. Provenzale, J. R. Mac-Fall // Depress Anxiety. – 2002. – Vol. 15. – P. 23–28.

Taylor W. D. Greater MRI lesion volumes in elderly depressed subjects than in control subjects / W. D. Taylor, J. R. MacFall, M. E. Payne, D. R. McQuoid, D. C. Steffens, J. M. Provenzale, K. R. Krishnan // Psychiatry Res. – 2005. – Vol. 139. –P. 1–7.

Manto M. Modulation of excitability as an early change leading to structural adaptation in the motor cortex / M. Manto, N. Oulad ben Taib, A. R. Luft // J. Neurosci. Res. – 2006. – Vol. 83, No 2. – P. 177 – 180.

Янушко М. Г. Когнитивные нарушения при эндогенных психозах: современные представления в свете дименсионального подхода / М. Г. Янушко, М. В. Иванов, А. В. Сорокина // Социальная и клиническая психиатрия. – 2014. – Т. 24, No 1. – С. 90–95

Martinez-Aran A. Treatment nonadherence and neurocognitive impairment in bipolar disorder / A. Martinez-Aran, J. Scott, F. Colom // J. of Clin. Psych. – 2009. – Vol. 70 (7). – Р. 1017–1023.

Malhi G. S. Bipolar disorder: it's all in your mind? The neuropsychological profile of a biological disorder / G. S. Malhi, B. Ivanovski, V. Szekeres // Can. J. Psychiat-ry. – 2004. – Vol. 49. – Р. 813–817.

Ершов Б. Б. Современные исследования когнитивного дефицита при аффективных расстройствах: нейропсихологический подход / Б. Б. Ершов, А. В. Тагильцева, М. В. Петров // Вестник ЮУрГУ. Серия «Психология». – 2015. – Т. 8, No 3. – С. 65–76.

Schmidt H. D. Future antidepressant targets: neurotrophic factors and related signaling cascades drug / H. D. Schmidt, M. Banasr, R. S. Duman // DiscovTo-day Ther Strateg. – 2008. – Vol. 5, No 3. – Р. 151–156.

Warner-Schmidt J. L. Hippocampal neurogene-sis: opposing effects of stress and antidepressant treatment / J. L. Warner-Schmidt, R. S. Duman // Hippocam-pus. – 2006. – Vol. 16, No 3. – P. 239–249.

AD'Sa C. Antidepressants and neuroplastici-ty / C. АD'Sa, R. S. Duman // Bipolar Disord. – 2002. – Vol. 4. – P. 183–94.

Пуговкина О. Д. Когнитивное функционирование и его динамика у больных терапевтически резистентными депрессиями при электросудорожной терапии и транскраниальной магнитной стимуляции / О. Д. Пуговкина // Социальная и клиническая психиатрия. – 2009. – Т. 19, No 1. – С. 29–34.

Hansson A. C. Dissociation of antidepres-sant-like activity of escitalopram and nortriptyline on behaviour and hippocampal BDNF expression in fe-male rats / A. C. Hansson, R. Rimondini, M. Heilig //J. Psychopharmacol. – 2011. – Vol. 25, No 10. – P. 1378–1387.

Imamura K. Cytokine production of activated microglia and decrease in neurotrophic factors of neu-rons in the hippocampus of Lewy body disease brains / K. Imamura, N. Hishikawa , K. Ono et al. // Acta Neuro-pathol. – 2005. – Vol. 109, No 2. – P. 141–150.