Evaluation of the dynamics of changes in the quantitative content of neuron growth factor (Beta-NGF) in the blood serum of patients who have suffered an ischemic stroke under the influence of complex physical rehabilitation

Abstract

The article is devoted to the study of dynamic of changes in the quantitative content of neuron growth factor (Beta-NGF) in the blood
serum of patients who have suffered ischemic stroke under the influence of complex physical rehabilitation. 116 patients in the recovery
period of ischemic stroke (IS) (from 3 to 6 months) were examined. The average age of the patients was 61.4±0.53 years. During the study
all patients were divided into two groups depending on the type of rehabilitation treatment. Group 1 consisted of 66 patients who received
standard drug therapy aimed at secondary prevention during the entire period of the study and undergoing a course of complex physical
rehabilitation. Group 2 consisted of 50 patients who received only standard drug therapy as part of secondary IS prevention. The control
group included 30 practically healthy persons of the appropriate age and subjects who, according to the anamnesis and neuroimaging
data, had no signs of a previous IS. The average age of the control group was 61.07±0.75 years. Beta-NGF was determined in 22 patients of
group 1 and group 2 before the beginning of inpatient treatment and after its completion. This study was also conducted once for 10 people
from the control group. The analysis of the results showed a significant decrease in the content of Beta-NGF in blood serum in patients with
IS in the recovery period, which, in our opinion, may be associated with hypoxic damage to the brain tissue. In favor of this, data indicate
the presence of a strong correlation between the level of Beta-NGF content and MMSE indicators. Also, the obtained data suggest that a
significant decrease in the level of Beta-NGF content can be an indicator of the presence of type 2 diabetes. Significantly higher quantitative
content of Beta-NGF in blood serum and statistically significant differences in dynamic changes during the study in patients of the first
group indicate that physical rehabilitation can contribute to an increase in the content of Beta-NGF and thus cause a positive effect on the
restoration of functions impaired as a result of a brain catastrophe.