Features of treatment of chronic brain ischemia in young patients with arterial hypertension

Abstract

Actuality: Increasing the frequency of hypertension among the young population is a socially significant problem. The insidiousness
of hypertension in young people is that it has the character of a disease with few symptoms. Since hypertension plays one of the main
roles in the pathogenesis of chronic disorders of cerebral blood circulation, including both arterial and venous systems, the search for
pathogenetically determined medicinal approaches to the elimination of cerebrovascular disorders, especially at a young age, continues.
The purpose of the study: to study the effectiveness, tolerability and safety of the combination of Flego and Cognitium in young
patients with chronic cerebral ischemia (CMI) on the background of hypertension.
Methods: clinical-neurological, psychodiagnostic (asthenic state scale (ASS), anxiety scores according to the Spielberger-Hanin scale
and Beck depression scale, Montreal scale of cognitive function assessment (MoCA)), ultrasound examination, general scale of clinical
impression, statistical.
Results: 52 patients (28 men and 24 women) at a young age with AMI on the background of hypertension were examined. The
median age of the examined patients was (37.7 ± 4.6) years; among them, 23 patients suffered from hypertension of the 1st century. and
29 patients with hypertension of the second stage. Patients were randomly divided into two groups - the first - 23 (44.2%) patients (received
only hypotensive drugs), the second - 29 (55.8%) patients (in addition to the standard hypotensive therapy received a combination of
Phlego and Cognitium). Dynamic monitoring of patients after 2 months of treatment did not show significant changes in the distribution
structure of objective clinical and neurological symptoms. However, positive dynamics of indicators of cognitive functions and the psychoemotional state of the subjects were observed, as well as a statistically significant decrease in the blood flow rate in the direct sinus at
the end of the 2-month course using the combination of Phlego and Cognitium (decreased from 36.27±2.84 cm/s to 25.65±1.47 cm/s.).
Conclusions: The introduction of the combination of Phlego and Cognitium into the treatment of young patients with arterial
hypertension and chronic brain ischemia had a positive effect on the subjective state, on indicators of asthenia, emotional and cognitive
state of the patients. A significant positive effect was noted in the dynamics of venous blood flow indicators (speed of blood flow in the
direct sinus). Such treatment was well tolerated by patients, had few side effects and was combined with other drugs