Psychoneuroimmunological aspects of post covid19 syndrome

Abstract

A sample screening study was conducted by anonymous questionnaire of 223 adult outpatients with signs of post COVID19 syndrome (PCS) from 1 to 3 months after the disease. Among the respondents 77.6% are men, 22.4% are women of different ages. Young and middle-aged people predominated. 77.3% of them were treated on an outpatient basis. 89.6% of respondents had mild to moderate disease. Viral pneumonia was diagnosed in 28.2%. Respiratory distress syndrome survived 5,8%. Re-infection of SARS-CoV-2 had 3,5%. Prolonged low-grade fever (more than 4 weeks) after the disease was maintained at 33.6%; in 15,6% revealed immunosuppression of the cell and phagocytosis. 75% were diagnosed with long-term fever of non-infectious origin. Complete recovery from 2 to 4 weeks was noted by 82.9%. Three months or more required 19,2% for convalescence. They were dominated by signs of CFS and psycho-emotional imbalance. Regarding cognitive disorders, the greatest difficulties arose with the perception of information in 12.7%, with its analysis in 9.8%, with decision-making in 8%. 25.9% of respondents note mnemonic disorders. Attention disorders occurred in 24.9% of respondents. Among the most pronounced mental states that manifested themselves in the post COVID19 period are: anxiety was: high level - 21%, medium level – 26.6%, low level – 40.7% of respondents, as well as irritability: severe – 37.5 %, expressed – 27.2%, weakly expressed – 35.3%; confusion: severe – 36.6%, severe – 19.1%, mild – 44.1%; depressive disorders: severe – 36.5%, severe – 19.1%, mild – 44.1%; fear, despair, apathy: strongly expressed – 33.9%, expressed – 26.3%, weakly expressed – 39.8% of respondents; panic, panic attacks was: high level – 41%, medium level – 14,1%, low level – 44.9%,  hysteria: strongly expressed – 42.7%, expressed –13.5%, weakly expressed – 47.6%; aggression, anger, irritability: strongly expressed – 41.9%, expressed – 18.9%, weakly expressed – 39.3% of respondents. A change in the value-semantic component of personality has been recorded. Thus, 38.9% of respondents became more aware of the value of life, 17.2% had a positive attitude towards the world.