THE INFLUENCE OF INDIVIDUAL FEATURES OF HEART RATE VEGETATIVE REGULATION ON NEUROHUMORAL AND ELECTROPHYSIOLOGICAL EFFECTS OF PROPRANOLOL

  • Ye.P. Melezhik
  • A.S. Isaeva

Анотація

The study of the vegetative status influence on neurohumoral and electrophysiological effects of  nonselective beta 1,2 – propranolol blocker was the aim of our work.. 13 healthy volunteers at the age of 24±4 years participated in the study. A dose of propranolol made up 0.8 mg/kg per os. The HRV study  was performed on the basis of 5-min ECG recordings which  were made in supine and upright postures before and 90 min after a single propranolol intake. According to the frequency spectral HRV indices that were fixed in supine posture before preparation intake, all theexamined volunteers were divided into two groups with prevalence of sympathetic (LF/HF>1, group A) and parasympathetic (LF/HF<1, group B) activity. According to the HRV recordings in supine posture  the vagotonic effect of the preparation was observed in group A and sympathotonic in group B. In supine position slow-down of the atrial conductivity caused by propranolol was more acute in group B. The neurohumoral and electrophysiological effects of the preparation were less acute when the volunteers were in upright posture. So the dependence of the propranolol effects on the initial neurohumoral regulation status was shown.

Завантаження

##plugins.generic.usageStats.noStats##

Посилання

1. Adamson P.B., Huang M.H., Vanoli E., et. al. Unexpected interaction between beta-adrenergic blockade and heart rate variability before and after myocardial infarction. A longitudinal study in dogs at high and low risk for sudden death. // Circulation. 1994. V. 90(2).

2. Badilini, F., Maison-Blanche, P., Coumel, P. Heart rate variability in passive tilt test: comparative evaluation of autoregressive and FFT spectral analyses.// Pacing. Clin. Electrophysiol. 1998. V. 21:5. P. 1122-1132.

3. Berger, R.D., Saul, J.P., Cohen, R.J. Transfer function analysis of autonomic regulation. I. Canine atrial rate response. // Am. J. Physiol. 1989. V. 256 (Heart Circ Physiol 25). P. H142-H152.

4. Cheema, A.N., Ahmed, M.W., Kadish, A.H., Goldberger J.J. Effects of autonomic stimulation and blockade on signal-averaged P wave duration. // J. Am. Coll. Cardiol. 1995. Aug. V. 26(2). P. 497-502.

5. Cook, J.R., Bigger, J.T. Jr., Kleiger, R.E., et. al. Effect of atenolol and diltiazem on heart period variability in normal persons. // J. Am. Coll. Cardiol. 1991. Feb. V. 17(2). P. 480-484.

6. Craft, N., Schwartz, J.B. Effects of age on intrinsic heart rate, heart rate variability, and AV conduction in healthy humans // Am. J. Physiology. 1995. Apr: 268 (4 Pt 2): H1441-1452.

7. Eckberg DL. Sympathovagal balance: a critical appraisal. // Circulation. 1997. V. 96. P. 3324-3332.

8. Eckberg, D.L. Beta-adrenergic blokade may prolong life in post-infarсtion patients in part by increasing va-gal cardiac inhibition. // Med. Hypotheses. 1984. Dec. V.15(4). P. 421-432.

9. Hojgaard, V.H., Holstein-Rathlou, N.H., Agner E,Kanters, K.J. Dynamics of spectral components of heart rate variability during changes in autonomic balance. //Am. J. Physiol. 1998. Jul. V. 275 (1 Pt. 2). P. H213-H219.

10. Kim, Y.H.; Ahmed, M.W.; Kadish, A.H.; Goldberger, J.J. Characterization of the factors that determine the effect of sympathetic stimulation on heart rate variability. // Pacing. Clin. Electrophysiol. 1997. Aug. V. 20 (8 Pt 1). P. 1936-1946.

11. Kitamura, K., Takata, S., Futamata, H., et.al. Effects of head-up tilting on vagal nerve activity in man. // Rinsho. Byori. 1997. Aug. V. 45(8). P. 771-777.

12. Malic M. Heart rate variability.// Curr. Opin. Cardiol. 1998. Jan. V. 13(1). P. 36-44.

13. Malliani, A., Pagani, M., Lombardi, F., Cerutti, S. Cardiovascular neural regulation explored in frequency domain.// Circulation. 1991. V. 84. P. 482 – 492.

14. Melezhik, Y.P., Isaeva, A.S., Yabluchansky, N.I. Nonselective b -blockers, autonomic regulation and phases of the heart cycle. Proceeding of the 1st Virtual Congress of Cardiology [Online] http://www.fac.org.ar/cvirtual. Jan - Apr. 2000

15. Montano, N., Ruscone, T.G., Porta, A., et.al. Power spectrum analysis of heart rate variability to assess the changes in sympathovagal balance during graded orthostatic tilt. // Circulation. 1994. V. 90. P. 1826-1831.

16. Nakagawa, M., Takahashi, N., Iwao, T., et. al. Evaluation of autonomic influences on QT dispersion using the head-up tilt test in healthy subjects. // Pacing. Clin. Electrophysiol.1999. Aug. V. 22(8). P. 1158-1163.

17. Pagani M., Lombardi F., Guzzetti S., et.al. Power spectral analysis of heart rate and arterial pressure variabil-ities as a marker of sympatho-vagal interaction in man and conscious dogs.// Circ. Res. 1986. V. 59. P.178-193.

18. Pitzalis, M.V., Massari, F., Passantino, A. The effects ofchronic beta-blockers administration on respiratory sinus arrhythmia. // Cardiologia. 1997. Feb. V. 42(2). P. 201-204.

19. Pousset, F., Copie, X., Lechat, P., Jaillon, P., Boissel, J.P., Hetzel, M., Fllette, F., Remme, W., Guize, L., Le Heuzey, J.Y. 1996. Effects of bisoprolol on heart rate variability in heart failure. // Am. J. Cardiol. 1996. Mar. V.15. № 77(8). P. 612-617.

20. Sandrone G., Mortara A., Torzillo D. et al Effects of beta blockers (atenolol or metoprolol) on heart rate variability after acute myocardial infarction. // Am. J. Cardiol. 1994. V. 15. № 74(4).

21. Silke, B., Guy, S., Riddel, J.G. Effects of beta-adrenoreceptor agonists and antagonists on heart rate variabil-ity in normal subjects assessed using summary statistics and nonliner procedures. // J. Cardiovasc. Pharmac. 1997. Dec. V. 30. № 6. P. 814-23.

22. Singh. B.N., Deedwania, P., Nademanee, K., et al. Sotalol. in Drugs. 1987. V. 34. P. 311-349.

23. Task Force of The Europian Society of Cardiology and The North American Society of Pacing and Electro-physiology. Heart rate variability. Standarts of measurement, physiologicalinterpretation, and clinical use. // Europ. Heart. J. 1996. V.17. P. 354-381.

24. Tulen. J.H., Boomsma, F. Cardiovascular control and plasma catecholamines during rest and mental stress: effects of posture. // Clin. Sci. (Colch). 1999. Jun. V.1. № 96(6). P. 567-576.

25. Wargon, M., Laude, D., Girard, A., Elgozi, J.L. Acute effects of bisodrolol on respiratory sinus arrythmis. // Fundam. Clin. Pharmac. 1998. V.12(4). P. 451-456.

26. Яблучанский Н.И., Мартыненко А.В., Исаева А.С. Основы практического применения неинвазивной технологии исследования регуляторных систем человека. Харьков. «Основа». 2000. C. 12-13.

27. Zhemaitite, D.I., Varonetskas, G.A., Sokolov, E.N. Interaction of the parasympathetic and sympathetic sec-tions of the autonomic nervous system in regulating cardiac rhythm. // Fiziol. Cheloveka. 1985. May-Jun. V. 11(3). P. 448-56.
Як цитувати
Melezhik, Y., & Isaeva, A. (1). THE INFLUENCE OF INDIVIDUAL FEATURES OF HEART RATE VEGETATIVE REGULATION ON NEUROHUMORAL AND ELECTROPHYSIOLOGICAL EFFECTS OF PROPRANOLOL. Вісник Харківського національного університету імені В. Н. Каразіна. Серія «Медицина», (2), 54-61. вилучено із https://periodicals.karazin.ua/medicine/article/view/7434
Номер
Розділ
Clinical Research