THE EFFECT OF EARLY POSTNATAL OVERNUTRITION ON PROOXIDANT-ANTIOXIDANT BALANCE AND NO-SYNTHASE ACTIVITY IN OLD RATS TISSUES

Автор(и)

  • Yu.V. Nikitchenko
  • V.N. Dzyuba
  • А.S. Popovich
  • А.А. Sheremet
  • V.V. Bondar

Ключові слова:

overnutrition, prooxidant-antioxidant balance, thyroid status, NO-synthase activity, rats

Анотація

The peculiarities of changes of prooxidant-antioxidant balance, thyroid status and NO-synthase activity in tissues of 20-month-old rats after overnutrition during first month after birth were investigated. It was found out that body weight, thyroxine concentration, lipid hydroperoxides content and NO-synthase activity in experimental rats were higher than in control ones. At the same time Se-dependent glutathione peroxidase activity was significantly decreased in liver of experimental rats. It is assumed that prooxidant-antioxidant system and thyroid state may be ones of the key links of the mechanism determining rats surviving in conditions of overnutrition.

Завантаження

Номер

Розділ

Fundamental Research

Як цитувати

THE EFFECT OF EARLY POSTNATAL OVERNUTRITION ON PROOXIDANT-ANTIOXIDANT BALANCE AND NO-SYNTHASE ACTIVITY IN OLD RATS TISSUES. (2015). Вісник Харківського національного університету імені В. Н. Каразіна. Серія «Медицина», 19, 12-16. https://periodicals.karazin.ua/medicine/article/view/6930

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