THE EFFECT OF EARLY POSTNATAL OVERNUTRITION ON PROOXIDANT-ANTIOXIDANT BALANCE AND NO-SYNTHASE ACTIVITY IN OLD RATS TISSUES
Keywords:
overnutrition, prooxidant-antioxidant balance, thyroid status, NO-synthase activity, ratsAbstract
The peculiarities of changes of prooxidant-antioxidant balance, thyroid status and NO-synthase activity in tissues of 20-month-old rats after overnutrition during first month after birth were investigated. It was found out that body weight, thyroxine concentration, lipid hydroperoxides content and NO-synthase activity in experimental rats were higher than in control ones. At the same time Se-dependent glutathione peroxidase activity was significantly decreased in liver of experimental rats. It is assumed that prooxidant-antioxidant system and thyroid state may be ones of the key links of the mechanism determining rats surviving in conditions of overnutrition.
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