THE CONTENT OF MCP-1 AND MMP-9 IN BLOOD SERUM OF PATIENTS WITH CHRONIC POLYPOID RHINOSINUSITIS

  • A. I. Onischenko Kharkiv National Medical University, Kharkiv, Ukraine
  • O. A. Nakonechna Kharkiv National Medical University, Kharkiv, Ukraine
  • A. S. Tkachenko Kharkiv National Medical University, Kharkiv, Ukraine
  • Yu. M. Kalashnik Kharkiv National Medical University, Kharkiv, Ukraine
Keywords: chronic polypoid rhinosinusitis, monocyte chemoattractant protein-1, MCP-1, matrix metalloproteinase-9, MMP-9

Abstract

The content of MCP-1 and MMP-9 inblood serum of patients with chronic polypoid rhinosinusitis was studied. It was found that this pathology led to a significant increase in MCP-1, which is a marker of fibrosis, in blood serum. The compensatory increase in MMP-9, serving as an antifibrotic factor, is much weaker. Such imbalance between profibrotic MCP-1 and antifibrotic MMP-9 indicates a lack of compensatory adaptation mechanisms of fibrolysis activation and contributes to the development of fibrosis in chronic polypoid rhinosinusitis.

Chronic polypoid rhinosinusitis is accompanied by an increase in blood serum MCP-1 levels in patients, which indicates the involvement of this chemokine in the proliferation of connective tissue in this pathology. High levels of the antifibrotic proteolytic enzyme MMP-9 are observed in blood serum of patients with chronic polypoid rhinosinusitis, which can serve as a sign of the activation of compensatory adaptive mechanisms aimed at inhibiting the extracellular matrix proliferation. The pronounced increase in MCP-1 levels against the background of a slight activation of MMP-9 in the blood serum of patients with chronic polypoid rhinosinusitis indicates insufficiency of compensatory mechanisms and activation of fibrosis.

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Author Biographies

A. I. Onischenko, Kharkiv National Medical University, Kharkiv, Ukraine

61022, Kharkiv, 4 Nauky Avenue

 
O. A. Nakonechna, Kharkiv National Medical University, Kharkiv, Ukraine

61022, Kharkiv, 4 Nauky Avenue

 
A. S. Tkachenko, Kharkiv National Medical University, Kharkiv, Ukraine

61022, Kharkiv, 4 Nauky Avenue

   
Yu. M. Kalashnik, Kharkiv National Medical University, Kharkiv, Ukraine

61022, Kharkiv, 4 Nauky Avenue

 

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Published
2017-09-11
How to Cite
Onischenko, A. I., Nakonechna, O. A., Tkachenko, A. S., & Kalashnik, Y. M. (2017). THE CONTENT OF MCP-1 AND MMP-9 IN BLOOD SERUM OF PATIENTS WITH CHRONIC POLYPOID RHINOSINUSITIS. The Journal of V. N. Karazin Kharkiv National University, Series "Medicine", (33), 23-26. Retrieved from https://periodicals.karazin.ua/medicine/article/view/9135
Section
Clinical research