ORAL CONSUMPTION OF CAFFEINATED ENERGY DRINKS AFFECTS THE MORPHOFUNCTIONAL STATE OF STRESS-ASSOCIATED ENDOCRINE GLANDS

  • M. O. Tkachenko Kharkiv National Medical University
  • G. I. Gubina-Vakylyuk Kharkiv National Medical University
  • T. V. Gorbach Kharkiv National Medical University
  • S. A. Denysenko Kharkiv National Medical University
  • A. S. Tkachenko Kharkiv National Medical University, Kharkiv, Ukraine
  • A. I. Onishchenko Kharkiv National Medical University, Kharkiv, Ukraine
  • E. P. Zhurba Kharkiv National Medical University, Kharkiv, Ukraine
Keywords: neurohypophysis, catecholamine, pineal gland, energy drinks, adrenal medulla, serotonin

Abstract

The aim of the research was to study the features of the morphofunctional state of the pineal gland, neurohypophysis and adrenal medulla, as well as the сontent of serotonin and catecholamine in the blood serum of rats against the background of energy drink administration during two weeks. In animals that consumed energy drinks during two weeks at a dose of 6 ml per kg of body weight, serum serotonin and catecholamine levels were determined. Histological, including morphometric, studies of the epiphysis, posterior pituitary and adrenal medulla were performed. Against the background of energy drink administration, an increase in the content of blood serum serotonin, norepinephrine and epinephrine was detected. The morphofunctional state of the endocrine glands investigated in the present study is strongly stimulated. Indirect signs of apoptosis of parenchymal cells in the pineal gland, neurohypophysis and adrenal medulla were established. The studied stress-associated endocrine glands in animals against the background of the two-week intake of energy drinks have signs of a sharp stimulation of hormone production (serotonin, norepinephrine, epinephrine, and vasopressin). Oral consumption of energy drinks during two weeks by experimental animals led to morphological changes in the pineal gland (prevalence of indolamine-producing pinealocytes), an increased load on these cells and probably their faster and frequent apoptosis. The number of pinealocytes in the pineal gland decreases and their morpho-functional load increases.2. Short-term administration (14 days) of caffeinated energy drinks affects the morphofunctional state of posterior pituitary, which can be highly likely interpreted as a result of overproduction of vasopressin.3. Overproduction of serotonin by pynea-locytes and catecholamine by adrenal glands is confirmed by their higher levels in blood serum of animals after the two-week-long intake of energy drinks compared to the control group.

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Author Biographies

M. O. Tkachenko, Kharkiv National Medical University

61022, Kharkiv, 4 Nauky Avenue, Kharkiv, Ukraine

G. I. Gubina-Vakylyuk, Kharkiv National Medical University

61022, Kharkiv, 4 Nauky Avenue, Kharkiv, Ukraine

 

T. V. Gorbach, Kharkiv National Medical University

61022, Kharkiv, 4 Nauky Avenue, Kharkiv, Ukraine

 

S. A. Denysenko, Kharkiv National Medical University

61022, Kharkiv, 4 Nauky Avenue, Kharkiv, Ukraine

 

A. S. Tkachenko, Kharkiv National Medical University, Kharkiv, Ukraine

61022, Kharkiv, 4 Nauky Avenue

 
A. I. Onishchenko, Kharkiv National Medical University, Kharkiv, Ukraine

61022, Kharkiv, 4 Nauky Avenue

 
E. P. Zhurba, Kharkiv National Medical University, Kharkiv, Ukraine

61022, Kharkiv, 4 Nauky Avenue

 

References

Energy drink consumption: beneficial and adverse health effects / [A. A. Alumni] // International Journal of Health Sciences. – 2015. – Vol. 9 (4). – P. 468–474.

A review of energy drinks and mental health, with a focus on stress, anxiety, and depression / [G. Richards, A. P. Smith] // Journal of Caffeine Research. – 2016. – Vol. 6 (2). – P. 49–63. doi:10.1089/jcr.2015.0033

Energy drinks: Potions of illusion / [N. Bedi, P. Dewan, P. Gupta] // Indian pediatrics. – 2014. – Vol. 51 (7). – P. 529–533.

Review of published cases of adverse cardiovascular events after ingestion of energy drinks. / [M. Goldfarb, C. Tellier, G. Thanassoulis] // The American journal of cardiology. – 2014. – Vol. 113 (1). – P. 168–172.

Meerson FZ, Pshennikova MG. Adaptacija k stressornym situacijam i fizicheskim nagruzkam. M., Medicina, 1988. – 258 p.

The neuropharmacology of taurine / [A. Barbeau, N. Inoue, I. Tsukada, R. F. Butterworth] // Life Sci. – 1975. – Vol. 17. – P. 669–678.

Published
2018-06-29
How to Cite
Tkachenko, M. O., Gubina-Vakylyuk, G. I., Gorbach, T. V., Denysenko, S. A., Tkachenko, A. S., Onishchenko, A. I., & Zhurba, E. P. (2018). ORAL CONSUMPTION OF CAFFEINATED ENERGY DRINKS AFFECTS THE MORPHOFUNCTIONAL STATE OF STRESS-ASSOCIATED ENDOCRINE GLANDS. The Journal of V. N. Karazin Kharkiv National University, Series "Medicine", (35), 6-11. https://doi.org/10.26565/2313-6693-2018-35-01