KEY FACTORS OF PATHOGENESIS OF CHRONIC PANCREATITIS IN FAMILY DOCTOR’S PRACTICS
Keywords:
chronic pancreatitis, pathogenesis
Abstract
During more than one hundred years of researching pathogenesis of chronic pancreatitis (CP) many of the hypothesis have been created. Some of them through time were denied, some were partly confirmed by results of clinical and experimental researchings and became hypothesis. However, not all the elements of pathogenesis of CP are clear till now. Probably, it is caused by large number of etiologic factors in development of CP, part of which have differences in pathogenesis. The hypothesis of 60s-70s of the last century were propounded and refuted exactly without taking into account these differences. The discoveries of the last 15 years, specifically determination of hereditary and autoimmune genesis of CP, have widened a notion of it’s pathogenesis. The majority of scientists consider a pathogenetic significance of the intraductal hypertension and intraductal protein and calcium precipitation. However, in opinion of some researchers, the mechanisms of its’ development are different. The fundamental pathophysiologic hypotheses of CP’s development, many of which are topical today, are considered in this article.
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References
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20. Montalto G. Les inhibiteurs proteiques de cris¬tallisation. Caracterisation et role potentiel dans les lithiases calciques / G. Montalto, L. Multigner, H. Sarles, A. De Coro // Nephrologie. – 2004. – Vol. 5. – P. 155-157.
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23. Gough D.B. Free radical inhibition and serial chemilu-minescence in evolving experimental pancre¬atitis / D. B. Gough, B. Т. Boyle, W. P. Joyce [et al.] // Brit. J. Surg. – 2006. – Vol. 77. – P. 1256-1259.
24. Graf R. A family of 16-kDa pancreatic secretory stress proteins form highly organized fibrillar structures upon tryptic activation / R. Graf, M. Schiesser, G. Scheele [et al.] // J. Biol. Chem. – 2005. – Vol. 276. – P. 2128-2138.
25. Lohse J. Calcium binding to the «stone proteins isolated from pancreatic stones of patients with chronic calcified pancreatitis / J. Lohse, R. Kraemer // Hoppe Seylers Z. Physiol. Chem. – 2000. – Vol. 365. – P. 549-554.
26. Mariani A. Differences of pancreatic stone morphology and content in patients with pancreatic lithiasis / A. Mariani, J. Bernard, M. Provansal-Cheylan [et al.] // Dig. Dis. Sci. – 2001. – Vol. 36. – P. 1509-1516.
27. Multigner L. Pancreatic stone protein, a phosphoprotein which inhibits calcium carbonate precipitation from human pancreatic juice / L. Multigner, A. De Caro, D. Lombardo [et al.] // Biochem. Biophys. Res. Commun. – 2003. – Vol. 110.- P. 69-74.
28. Gerbaud V. Mechanism of calcite crystal growth inhibition by the N-terminal undecapeptide of lithostathine / V. Gerbaud, D. Pignol, E. Loret [et al.]//J. Biol. Chern. – 2000. -Vol. 275. – P. 1057-1064.
29. Gukovsky I. Early NF-kappa B activalion is associated with hormone-induced pancreatitis / I. Gukovsky, A. Gukovskaya, T. Blinman [et al.] // Amer. J. Physiol. – 2008. – Vol. 275. – P. 1402-1414.
30. Guy O. Protein content If precipitates present in pancreatic juice of alcoholic subjects and patients with chronic calcifying pancreatitis / O. Guy, G. Robles-Diaz, Z. Aldrich [et al.] // Gastroenterology. – 2002. – Vol. 84. – P. 102-107.
31. Hoyakawa T. Trypsinogen content of pancreatic calculi in chronic calcified pancreatitis in man / T. Hoyakawa, T. Kondo, T. Shibata [et al.] // Dig. Dis. Sci. – 2004. – Vol. 39. – P. 1345-1350.
32. Hietaranta A.J. Relationship between NF-kappa B and trypsinogen activation in rat pancreas after supramaximal caerulein stimulation / A. J. Hietaranta, A. X. Saluja, L. Bhagat [et al.] // Biochem. Biophys. Res. Commun. – 2005. – Vol. 280. – P. 388-395,
33. Hofbauer B. Intra-acinar cell activation of trypsinogen during cerulein-induced pancreatitis in rats / B. Hofbauer, A. Saluja, M. Lerch [et al.] // Amer. J. Physiol. – 2006. – Vol. 275. – P. 352-362.
34. Jin C. X. Pancreatic stone protein of pancreatic calculi in chronic calcified pancreatitis in man / C. X. Jin, S. Naruse, M. Kitagawa [et al.] // JOP. J. Pancreas (Online). – 2007. – Vol. 3, N 2. – P. 54-61.
35. Katsuzaki T. Enzyme immunoassay for specific analy¬sis of
pancreatic stone ptroteins in human pan-creatic juice / T. Katsuzaki, N. Tatemichi, C. Takeichi [et al.] // J. Clin. Lab. Anal. – 2001. – Vol. 6. – P. 375-378.
36. Koepell G. Pseudocysts in chronic pancreatitis: a morphological analysis of 57 resection specimens and 9 autopsy pancreata / G. Koepell, B. Maillet // Pancreas. – 2007. – Vol. 6. – P. 266-274.
37. Koike H. Pan¬creatic effects of ethionine: blockade of exocytosis and appearance of crinophagy and autophagy precede cellular necrosis / H. Koike, M. Steer, J. Meldolesi // Amer. J. Physiol. – 2000. – Vol. 242. – P. 297-307.
38. Lerch M.M. Pancreatic duct obstruction triggers acute necrotizing pancreatitis in opossum / M. M. Lerch, A. K. Saluja, M. Runzi [et al.] // Gastroenterology. – 2002. – Vol. 104. – P. 853-861.
39. Miszczuk-Janska B. Alfa 1-Proteinase inhibitor in pure human pancreatic juice. Characterization of a com¬plexes form in patients with chronic calcifying pancreatitis and its significance / B. Miszczuk-Janska, O. Guy, C. Figarella // Hoppe Seylers Z. Physiol. Chem. – 2003. – Vol. 364. – P. 1597-1601.
40. Muller J.M. Study of gene regulation by NF-kappa B and AP-1 in response to reactive oxygen interme-diates / J. M. Muller, R. A. Rupee, P. A. Baeuerle // Methods. – 2007. – Vol. 11. – P. 301-312.
41. Multigner L. Radiolucent pancrea¬tic stones // New Engl. J. Med. – 2006. – Vol. 314. – P. 248.
42. Multigner L. Pancreatic stone protein. I. Implications in stone formation during the course of chronic pancreatitis / L. Multigner Sorles, H. Lombardo, A. DeCoro // Gastroenterology. – 2005. – Vol. 89. – P. 381.
43. Pap A., Boros L. Alcohol-induced chronic pancreatitis in rats after temporary occlusion of biliopancreatic ducts with ethi-bloc // Pancreas. – 2002. – Vol. 4. – P. 249 – 255.
44. Patard L. An insight into the role of human pancreatic lithostathine / L. Patard, J.-Y. Lallemand, V. Stoven // JOP. J. Pancreas (Online). – 2003. – Vol. 4, N 2. – P. 92 – 103.
45. Figarella C. Alkaline phosphatase and acid lysosomal hydrolases in pancreatic juice and fibroblast cell cultures of patients with chronic calcifying pancreatitis / C. Figarella, E.Vogt, P. Hosli // Europ. J. Clin. Invest. – 2003. – Vol. 12. – P. 145-149.
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How to Cite
Vovk, K., Sokruto, O., Nikolenko, J., & Savchenko, V. (1). KEY FACTORS OF PATHOGENESIS OF CHRONIC PANCREATITIS IN FAMILY DOCTOR’S PRACTICS. The Journal of V. N. Karazin Kharkiv National University, Series "Medicine", (18), 49-58. Retrieved from https://periodicals.karazin.ua/medicine/article/view/6956
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