USE NONSTEROIDAL ANTI-INFLAMMATORY DRUGS IN THERAPEUTIC PRACTICE
Abstract
The clinical pharmacology of nonsteroidal anti-inflammatory drugs (NSAIDs) within the classification system of ATS is represented. The classification and characteristics of the pharmacokinetics and pharmacodynamics of the drugs of this group are given. The algorithm of NSAIDs’ use in therapeutic practice is described: by the articular syndrome, by pain syndrome of different genesis and by other conditions. The absolute and relative contraindications and side effects of NSAIDs as well as control measures by their long-term use are covered in detail.
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2. Насонов Е. Л. Кардиоваскулярные осложнения ингибиторов ЦОГ-2 – вопросов больше, чем ответов / Насонов Е. Л. // Русский медицинский журнал. - 2005. – Т. 13, № 7. – С. 383-391.
3. Насонов Е. Л. Нестероидные противовоспалительные препараты в ревматологии / Насо-нов Е. Л. // Лечащий врач. – 2006. – № 2. – С. 3-6.
4. Насонов Е. Л. Применение нестероидных противовоспалительных препаратов. Клинические рекомендации / Насонов Е. Л., Каратеев А. Е. // Русский медицинский журнал. – 2006. – Т. 14, № 25. – С. 1769-17.
5. Руденко Н. Н. Нестероидные противовоспалительные препараты и желудочно-кишечный тракт: «нетрадиционные» осложнения тера¬пии / Руденко Н. Н., Томаш О. В., Сибилев А. В. // Режим доступа : www.medicusamicus.com/index.php?action=4x965-13gx2.
6. Яременко О. Б. Кардиоваскулярная безопасность нестероидных противовоспалительных препара-тов: суть проблемы и алгоритм практических действий / Яременко О. Б // THERAPIA Український медичний вісник. – 2006. – № 2. – С. 30-36.
7. Anti-rheumatic drugs Ed. E.C. Huskinson, Praeger, 1983.
8. FDA/Center for Drug Evaluation and Research 7.04.05. Available from: http://www.fda.gov/cder/drug/ infopage/COX2/default.htm.
9. Hawkey C. J. COX-2 inhibitors. Lancet. – 1999. 353 : 307-314.
10. Moore A., Derry S. Gastrointestinal harm from NSAIDs: an operations research approach. – EULAR Congr. 2006 abstr.
11. Wong D., Wang M., Cheng Y., Fitzgerald G.A. Cardiovascular hazard and non-stertoidal anti-inflamma-tory drugs. Curr Opin Pharmacol. – 2005. 5 : 204-210.
12. Sachs C. Oral analgesics for acute nonspecific pain // Am. Fam. Physician. – 2005. 71 : 913-918.
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