CONDITION OF LIPID PEROXIDE OXIDATION AND ANTIOXIDANT SYSTEM IN PATIENTS WITH INFECTIOUS MONONUCLEOSIS

  • Mikola Shustval V.N. Karazin Kharkiv National University, Kharkiv, Ukraine
  • Tetiana Liadova V.N. Karazin Kharkiv National University, Kharkiv, Ukraine https://orcid.org/0000-0002-9255-6019
  • Olha Volobuieva Kharkiv National Medical University, Kharkiv, Ukraine https://orcid.org/0000-0002-5569-1748
  • Ksenia Pavlikova Kharkiv National Medical University, Kharkiv, Ukraine
  • Alla Gamilovska Kharkiv National Medical University, Kharkiv, Ukraine
Keywords: infectious mononucleosis, lipid peroxides, antioxidant system, catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase, dyne conjugates, malonic dialdehyde, glutathione

Abstract

The indicators of the activity of lipid peroxidation and the antioxidant system were studied in dynamics in 158 patients with infectious mononucleosis depending on the severity of the clinical course of the disease. It is proved that lipid peroxidation is significantly activated in patients with infectious mononucleosis as the severity of the disease increases and therefore increases the oxidative activity of blood plasma, the concentration of dyne conjugates and malondialdehyde in the blood, decreases the activity of antioxidant enzymes of erythrocytes (catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase), glutathione peroxidase and glutathione reductase activity in plasma and lowering the concentration of total and reduced glutathione in the blood, as well as reduce the antioxidant activity of blood plasma and erythrocytes.

Lipid peroxidation significantly increase and the activity of the antioxidant system decrease in patients with infectious mononucleosis in the acute period of the disease, as evidenced by the increased concentration of dyne conjugates, malonic dialdehyde and total oxidative plasma activity in the blood, reduced activity of the total antioxidant activity of plasma and erythrocytes, the decrease in the activity of antioxidant enzymes of erythrocytes catalase, superoxide dismutase, glutathione peroxidase, glutathione peroxidase and glutathione reductase of blood plasma, the decrease in the concentration of glutathione in the blood.

The most pronounced disorders of lipid peroxidation and antioxidant system activity were found in patients with moderate-severe and severe infectious mononucleosis.

The development of cytolytic syndrome in infectious mononucleosis is associated with the action of reactive oxygen forms species and lipid hydroperoxide.

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Author Biographies

Mikola Shustval, V.N. Karazin Kharkiv National University, Kharkiv, Ukraine

Svobody sq., 6, Kharkiv, 61022, Ukraine

Tetiana Liadova, V.N. Karazin Kharkiv National University, Kharkiv, Ukraine

Svobody sq., 6, Kharkiv, 61022, Ukraine

Olha Volobuieva, Kharkiv National Medical University, Kharkiv, Ukraine

61022, Kharkiv, 4 Nauky Avenue

Ksenia Pavlikova, Kharkiv National Medical University, Kharkiv, Ukraine

61022, Kharkiv, 4 Nauky Avenue

Alla Gamilovska, Kharkiv National Medical University, Kharkiv, Ukraine

61022, Kharkiv, 4 Nauky Avenue

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Published
2019-01-08
How to Cite
Shustval, M., Liadova, T., Volobuieva, O., Pavlikova, K., & Gamilovska, A. (2019). CONDITION OF LIPID PEROXIDE OXIDATION AND ANTIOXIDANT SYSTEM IN PATIENTS WITH INFECTIOUS MONONUCLEOSIS. The Journal of V. N. Karazin Kharkiv National University, Series "Medicine", (36), 33-40. Retrieved from https://periodicals.karazin.ua/medicine/article/view/12180
Section
Clinical research

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