Synthesis and 1,3-dimethylation of 5-ethoxycarbonyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one
Abstract
1,3-Dimethylation of 5-ethoxycarbonyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one can be carried out in one stage, using the system DMF–NaH and the excess of MeI. It is shown, that 5-ethoxycarbonyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one can be obtained with a good yield (55%) by reflux of ethyl 3,3-diethoxypropanoate, urea and benzaldehyde in acetic acid. The conditions of the protocol for the synthesis of ethyl 3,3-diethoxypropanoate starting from bromoacetic ester and ortho-formic ester by modified Reformatsky reaction have been optimized.
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