The peculiarities of the behavior of alendronic acid in micellar solutions of cetyltrimethylammonium bromide
Abstract
Bisphosphonates are active substances for treatment of bone deceases. One of the representatives of this group of substances is 4-amino-1-hydroxybutylidene bisphosphonic (alendronic) acid. Micellar media of colloidal surfactants are usually considered as models of biological media for investigation of protolytic equilibria of pharmaceutical compositions. In this paper, three dissociation constants, Ka3, Ka4, and Ka5, of alendronic acid have been determined in micellar solution of cetyltrimethylammonium bromide (CTAB) with the concentrations of 0.01 mol/L and 0.10 mol/L via potentiometric titration.
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