Human erythrocyte membrane permeability for nonelectrolytes - series of amides

Authors

  • O. I. Gordiyenko Institute for Problems of Cryobiology and Cryomedicine of NAS of Ukraine Author
  • T. P. Linnik Institute for Problems of Cryobiology and Cryomedicine of NAS of Ukraine Author

Keywords:

erythrocyte membrane, permeability, amides

Abstract

Permeability coefficients for human erythrocyte membranes for a series of amides have been determined. When molecular diameter is greater than 4Å a significant decrease in aqueous permeability has been shown. Permeability coefficients of erythrocytes incubated with pCMBS which is known as a protein channel blocker, rise with a distribution coefficient increase between hydrophilic and hydrophobic phases for the series of amides with the correlation coefficient of 0.94. The results obtained give evidence that the substances investigated permeate erythrocyte membrane by two passes: through aqueous protein channels and directly through lipid phase.

Downloads

Download data is not yet available.

Author Biographies

  • O. I. Gordiyenko, Institute for Problems of Cryobiology and Cryomedicine of NAS of Ukraine

    23 Pereyaslivska St., Kharkiv 61015, Ukraine

  • T. P. Linnik, Institute for Problems of Cryobiology and Cryomedicine of NAS of Ukraine

    23 Pereyaslivska St., Kharkiv 61015, Ukraine

Downloads

Published

2019-04-12

Issue

Vol. 1 No. 12 (2003): Біофізичний вісник

Section

Cell biophysics

License

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).

How to Cite

Human erythrocyte membrane permeability for nonelectrolytes - series of amides. (2019). Biophysical Bulletin, 1(12), 92-96. https://periodicals.karazin.ua/biophysvisnyk/article/view/13032

Most read articles by the same author(s)