Complex formation of aromatic biologicaly active compounds with antibiotic topotecan: analysis by means of 1h nuclear magnetic resonance spectroscopy
Keywords:
topotecan, complexation, heteroassociation, interceptor, protector mechanismsAbstract
In the present work with use of 1H NMR spectroscopy data the analysis of heteroassociation of antibiotic
topotecan (TPT) with aromatic biologically active compounds (BAC): caffeine, mutagens ethidium
bromide and proflavine, antibiotic daunorubicin, vitamins flavin-mononucleotide and nicotinamide, is
carried out. The analysis was performed taking into account the existence of the antibiotic in aqueous
environment under physiological pH in two various forms – lactone and carboxylate. Equilibrium
constants of heteroassociation and induced chemical shifts of TPT protons (in lactone and carboxylate
forms) and the BACs within the complexes were obtained. It is found that the complex formation TPTBАС is characterized by the stacking of the chromophores and additionally stabilized in case of
proflavine by intermolecular hydrogen bond
Downloads
Downloads
Issue
Section
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
