Electrical properties of the protein molecule in two - terminal device
Keywords:
proteins, impedance, aminoacids, complex networks, electrical properties, conformational changesAbstract
Here we present a mathematical model of the single protein molecule in two-terminal device as complex irregular impedance network. It is applied for the prediction of the response of the electronic nanobiosensor based on the single molecule of G-protein coupled receptor (GPCR) family protein. The protein molecule is modeled as a complex network of elementary impedances where nodes correspond to alpha-carbon atoms of the protein aminoacids residues, and links correspond to some electrical interaction between them. Links connect each pair of aminoacids close enough in space and each link corresponds to an elementary impedance. The impedance value depends on the kin of the corresponding pair of aminoacids and distance between them. Correspondingly, conformational changes of the GPCR molecule transmit to the variation of its electrical properties. The change of rhodopsin molecule impedance with photon capture is calculated. The results for the different values of model parameters are presented and discusse.
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