Evaluation of interstrain differences in fıtness components of Drosophila melanogaster strains with neurological disorders
Abstract
Some components of fitness and locomotor activity of Drosophila melanogaster strains Sh14, slo1, paraST76 with neurological mutations that affect ion channels have been studied in comparison to wild type strains Canton-S and Oregon. The genotype influence on fertility, vitality and locomotor activity of imago has been observed. Sex differences in locomotor activity were established only for a wild type strain C-S. Abnormal work of ion channels effect on mechanisms of neurodegenerations and the formation of fitness of drosophila is discussed.
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Лакин Г.Ф. Биометрия. – Москва: Высшая школа, 1990. – 351с. /Lakin G.F. Biometriya. – Moskva: Vysshaya shkola,1990. – 351s./
Ратнер В.А., Васильева Л.А. Мобильные генетические элементы (МГЭ) и эволюция геномов // Современные проблемы теории эволюции. – М.: Наука, 1993. – С. 43–59. /Ratner V.A., Vasilyeva L.A. Mobilnyye geneticheskiye elementy (MGE) i evolutsiya genomov. – M.:Nauka, 1993. – S. 43–59./
Atkinson N.S., Robertson G.A., Ganetzky B. A component of calcium-activated potassium channels encoded by the Drosophila slo locus // Science. – 1991. – Vol.253. – P. 551–555.
Bingwei L. Recent advances in using Drosophila to model neurodegenerative diseases // Apoptosis. – 2009. – Vol.14. – P. 1008–1020.
Connolly K. Locomotor activity in Drosophila // Anim. Behav. – 1967. – Vol.14. – P. 444–449.
Fergestad T., Ganetzky B., Palladino M.J. Neuropathology in drosophila membrane excitability mutants // Genetics. – 2006. – Vol. 172 (2). – P. 1031–1042.
Fortini M. E., Skupski M. P., Boguski M. S., Hariharand I.K. A survey of human disease gene counterparts in the drosophila genome // J Cell Biol. – 2000. – Vol.150 (2). – P. 23–30.
Jordan K.W., Morgan Th.J., Mackay T.F.C. Quantitative trait loci for locomotion behavior in Drosophila melanogaster // Genetics. – 2006. – Vol.174. – P. 277–278.
LeDoux M.S. Movement disorders: genetics and models. – Academic Press, 2005. – P. 487–504.
Parker L., Howlett I.C., Rusan Z.M., Tanouye M.A. Seizure and epilepsy: studies of seizure disorders in drosophila // Int. Rev. Neurobiol. – 2011. – Vol.99. – P. 1–21.
Peixoto A.A., Hall J.C. Analysis of temperature-sensitive mutants reveals new genes involved in the courtship song of Drosophila // Genetics. – 1998. – Vol.148 (2). – P. 827–838.
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