Neurofibromatosis in Neurological Practice (Description of a Clinical Case of Neurofibromatosis 2nd Type)

А. Ostrovsky Gomel State Medical University

Abstract

Neurofibromatosis is a complex genetic disorder with multiple symptoms and significant phenotypic variability. The most severe is second type of neurofibromatosis. It characterizes by tumors of central and peripheral nervous system. The article describes a complex clinical case of neurofibromatosis type 2. Such a clinical case in neurological practice can be found infrequently. The complexity of diagnosis and treatment of these diseases requires a coordinated multidisciplinary approach.

Downloads

Download data is not yet available.

References

Farrell C. J., Plotkin S. R. Genetic causes of brain tumors: neurofibromatosis, tuberous sclerosis, von Hippel-Lindau, and other syndromes. Neurol. Clin., 2007, vol. 25, pp. 925-946.

Ferner R. E. Neurofibromatosis 1 and neuro-fibromatosis 2: a twenty first century perspective. Lancet Neurol., 2007, vol. 6, pp. 340-351.

Gottfried O. N., Viskochil D. H., Fults D. W. [etal.] Molecular, genetic, and cellular pathogenesis of neuro-fibromas and surgical implications. Neurosurgery, 2006, vol. 58, pp. 1-16.

Savar A., Cestari D. M. Neuro-fibromatosis type I: genetics and clinical manifestations. Semin. Ophthalmol., 2008, vol. 23, pp. 45-51.

Williams V. C., Lucas J., Babcock M. A. [et al.] Neuro-fibromatosis type 1 revisited. Pediatrics, 2009, vol. 123, pp. 124-133.

Otibi M., Rutka J. T. Neurosurgical implications of neurofibromatosis Type I in children. Neurosurg Focus, 2006, vol. 20, pp. 130-139.

Yohay K. Neurofibromatosis type 1 and associated malignancies. Curr. Neurol. Neurosci. Rep., 2009, vol. 9, pp. 247-253.

Hottinger A. F., Khakoo Y. Neuro-oncology of Neurofibromatosis Type 1. Curr. Treat. Options Neurol., 2009, vol. 11, pp. 306-314.

Asthagiri A. R., Parry D. M., Butman J. A. [et al.] Neurofibromatosis type 2. Lancet, 2009, vol. 6, pp. 1974-1986.

Nowak C. B. The phakomatoses: dermatologic clues to neurologic anomalies. Semin. Pediatr. Neurol., 2007, vol. 14, pp. 140-149.

Lee M. J., Stephenson D. A. Recent developments in neurofibromatosis type 1. Curr. Opin. Neurol., 2007, vol. 20, pp. 135-141.

Gerber P. A., Antal A. S., Neumann N. J. [et al.] Neurofibromatosis. Eur. J. Med. Res., 2009, vol. 14, pp. 102-105.

Mc. Clatchey A. I. Neurofibromatosis. Annu. Rev. Pathol., 2007, vol. 2, pp. 191-216.

Barker D., Wright E., Nguyen K. [et al.] Gene for von Recklinghausen neurofibromatosis is in the pericentromeric region of chromosome 17. Science, 1987, vol. 236(4805), pp. 1100-1102.

Fenichel G. M. Clinical pediatric neurology. Asigns and symptoms approach. Philadelphia, Saunders Elsevier, 2009, 415 p.

Rubenstain A. E., Korf B. R. Neurofibromatosis. A Handbook for patients, families, and health care professionals. Thieme medical publishers Inc. Georg Thieme Verlag, NY, Stuttgart, 1990.

WolkenstainP., DecqP. Neurofibromatosis P.Wolkenstain. Neurochirurgie, 1998, vol. 44(4), pp. 267-272.

David R. B., Bodeinsteiner J. B., Mandelbaum D. E. Clinical pediatric neurology. New York, Demos Medical Publishing, 2009, 622 p.

Menkes J. H., Sarnat H. B., Maria B. L. Child Neurology. 7th ed., Copyright, 2006, Lippincott Williams & Wilkins, 2006, 1156 p.