EEG PECULIARTITIES AND KINDLED SEIZURES UNDER CONDITION OF TRANSCRANIAL MAGNETIC STIMULATION

  • L.S. Godlevsky
  • A.A. Shandra
  • A.I. Brusentsov
  • E.M. Barnyak
  • A.M. Mazko
  • A.V. Mandel
  • A.V. Zhylinskaya
  • A.A. Oleynik

Abstract

Transcranial magnetic stimulation (TMS) at low frequency (2/s for 10 s, 0.1 Tl at the heightof the impulse peak) induced an increase in delta bandwidth power and a marked reduction intheta and alpha rhythms in the basal EEG in rats kindled via amygdalar electrical stimulation(ES). A marked reduction in beta and gamma bandwidth power was also seen. All effects wereseen within half an hour of TMS and were brain structure-dependent. Amygdalar ES did notinduce generalized clonic-tonic fits when applied to kindled rats after TMS. The duration ofgeneralized epileptoform activity was also shorter after TMS. A reduction in theta, beta, andgamma rhythms and an increase in delta rhythm at the moment of cessation of epileptiform discharge (ED) (last 16 s of discharge) in TMS-kindled rats were observed. Thus, a suppressiveantiseizure effect can be seen when relatively low intensity TMS is used, and the effects might be mediated through delta rhythmogenesis activation.

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How to Cite
Godlevsky, L., Shandra, A., Brusentsov, A., Barnyak, E., Mazko, A., Mandel, A., Zhylinskaya, A., & Oleynik, A. (1). EEG PECULIARTITIES AND KINDLED SEIZURES UNDER CONDITION OF TRANSCRANIAL MAGNETIC STIMULATION. The Journal of V. N. Karazin Kharkiv National University, Series "Medicine", (1), 30-35. Retrieved from https://periodicals.karazin.ua/medicine/article/view/7451
Issue
No. 1 (2000)
Section
Fundamental research

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