COURSE FEATURES OF THE PEPTIC ULCER IN PATIENTS WITH ISCHEMIC HEART DISEASE
Abstract
The mutually aggravating influences of one disease on the clinical course of the other one are observed in the combination of ischemic heart-disease (IHD) and peptic ulcer (PU). The purpose of the present work is to determine the course features of the concomitant PU in the patients with IHD and possibilities of its drug correction. Examination of 114 patients was carried out under conditions of cardiological department of the Kharkov Regional Hospital; during the FGDS, PU (33,3%) was discovered in 38 of the patients with the IHD at the age of 30-65 (47,4±4,9). The course feature of the PU in combination with IHD is change of clinicolaboratory criteria, that shows up in 50% cases with pain syndrome with moderate monotonous intensity; presence of dyspeptic syndrome (in 34% cases) in the form of meteorism and diarrhea (in 27% cases) and constipation (in 42% cases); increase of secretory and acid-forming gastric function (17,1% cases); semination of mucous coat of stomach with helicobacterium infection (in 50% cases).
Abnormality of the cardiovascular fitness with PU and IHD was accompanied by tachycardia, moderate increase of blood pressure and ST segment depression, that was predisposing to the rise of aggression factor in the mucous coat of stomach with impaired microcirculation, trophic disturbances and development of the PU (in 33%). The complex therapy in PU with IHD, including the use of clacid, ammoxicillin, pariet in combination with actovegin, results in improving of therapeutic effects and contributes to acceleration of healing of ulcerous defect of the mucous coat of stomach.
Downloads
References
2. Крылов А.А. // Клиническая медицина. - 2000. - №1. - С. 56-58.
3. Лазебник Л.Б., Дроздов В.Н. // Клиническая геронтология. - 2001. - № 1-2. - С. 3-5.
4. Логинов А. С., Звенигородская Л. А., Потапова В. Б. и др. // Терапевтич. архив. - 2001. - № 2. - С. 9-13.
5. Решетников О. В., Усов С. А., Куринович С. А. и др. // Терапевтический архив - 2000. - № 2 - С. 16-19.
6. Эльштейн Н.В. // Гастробюллетень. - 2001. - № 2-3. - С. 99.
7. Silverstein F. // New stand. arthr, care. - 2006. - №1. - P. 2-6.
8. Marshall B. NSAIDs and Helicobacter pylori: therapeutic options // Lancet. - 2004. - Vol. 352. - P. 1001-1003.
9. Bytzer P. // An interactive Symposium 10 UEGW Abstract boor Gentva. - 2005. - P. 6-7.
10. Birnie D.H., Holme E.R., McKay I.C. et al. // Europ. Heart J. - 2006. - Vol.19. - P. 387-394.
11. Befrits R., Sjostedt S., Odman B., et al. // Helicobacter. - 2005. - Vol.5. - № 4. - P.202-205.
12. Kowalski M., Konturek P.C., Piemazek P., et al. // Dig. Liver. Dis. - 2006. - Vol.33. - № 3. - Р.222-9.
13. Pace F., Bianchi Porro G. // Dig. Liver. Dis. - 2006. - Vol.32 (Suppl 3). - P.202-206.
The Journal of V. N. Karazin Kharkiv National University, series Medicine has following copyright terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work’s authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal’s published version of the work, with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
