PROGNOSTIC VALUE NT PRO-BNP IN PATIENTS WITH ACS
Keywords:
N-terminal proB-type natriuretic peptide, acute coronary syndrome, prognosis
Abstract
The aim of this study was to define the utility of the measurement N-terminal pro-brain natriuretic peptide (NTproBNP) and other clinical and biochemical markers to predict adverse events at 1 year in patients with ACS. Parameters with significant differences in died and surviving patients were taken for analysis: age, heart rate (HR) at admission, levels of hemoglobin and NTproBNP. Curves of sensitivity and specificity were used based on the method of ROC analysis and cut-off values were chosen for each variable. Ball scoring was performed for each parameter regard to the cut-off value and a scale for calculating the summarized diagnostic coefficient (DC) by the method of Gubler was offered. A multimarker approach included on NTproBNP, hemoglobin, HR at admission and age and the summation of balls based on offered scale and calculating DC provides information in terms of ACS prognosis at 1 year, with a worse outcome for those with diagnostic coefficient has positive value (sensitivity 88,9 % and specificity 93,8 %).
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References
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2. Ruiz-Bailén M. Cardiogenic shock in acute coronary syndrome / Ruiz-Bailén M, Rucabado-Aguilar L, Expósito-Ruiz M et al. // Med Sci Monit. – 2009. – Vol. 15, № 3. ¬– P. 57–66.
3. Hama N. Rapid ventricular induction of brain natriuretic peptide gene expression in experimental acute myocar¬dial infarction / Hama N., Itoh H., Shirakami G. et al. // Circulation. – 1995. – Vol. 92. – P. 1558–1564.
4. Heeschen C., Hamm C. W. N-Terminal Pro-B-Type Natriuretic Peptide Levels for Dynamic Risk Stratification of Patients With Acute Coronary Syndromes / Heeschen C., Hamm C. W. // Circulation. – 2004. – Vol. 110. – P. 3206–3212.
5. Вальд А. Последовательный анализ / А. Вальд. – М. : Физматгиз, 1960.
6. Гублер Е. В. Вычислительные методы анализа и распознавания патологических процессов / Е. В. Гублер. – М. : Медицина, 1978.
7. Benamer H. Comparison of the prognostic value of C-reactive protein and troponin I in patients with unstable angina pectoris / Benamer H., Steg P. G., Benessiano J. et al. // Am. J. Cardiol. – 1998. – Vol. 1 : 82 (7). – P. 845–850.
8. Brügger-Andersen T. B-type natriuretic peptide is a long-term predictor of all-cause mortality, whereas high-sensitive C-reactive protein predicts recurrent short-term troponin T positive cardiac events in chest pain patients : a prognostic study / Brügger-Andersen T., Pönitz V., Staines H., et al. // BMC. – Cardiovasc Disord. – 2008. – Vol. 25, № 8 – P. 34.
9. Верткин А. Л. Мозговой натрийуретический пептид при остром коронарном синдроме без подъема сегмента ST / А. Л. Верткин, Д. Б. Сапрыгин, В. А. Мошина // http://www.consilium-medi-cum.com/magazines/cm/medicum/article/11286.
10. Джаиани Н. А. Мозговой натрийуретический пептид у больных инфарктом миокарда с подъемом сегмента ST. Прогностическое значение / Н. А. Джаиани, А. Г. Кочетов, И. В. Косицына, А. В. Голубев, Т. М. Ускач, С. Н. Терещенко // Терапевтический архив. – 2006. – № 78,4. – С. 21–26 .
11. Jernberg T. N-terminal pro brain natriuretic peptide on admission for early risk stratification of patients with chest pain and no ST-segment elevation / Jernberg T., Stridsberg M., Venge P., Lindahl B. // J. Am. Coll. Cardiol. – 2002. – Vol. 7, № 40 (3). – P. 437–445.
12. De Lemos J. A. The prognostic value of B-type natriuretic peptide in patients with acute coronary syndro-mes / De Lemos J. A., Morrow D. A., Bentley J. H., Omland T., Sabatine M. S., McCabe C. H., Hall C., Cannon C. P., Braunwald E.//N. Engl. J. Med. – 2001. – Vol. 4 : 345 (14). – P. 1014–1021.
13. Omland T. Plasma brain natriuretic peptide as an indicator of left ventricular systolic function and long-term survival after acute myocardial infarction. Comparison with plasma atrial natriuretic peptide and N-terminal proatrial natriuretic peptide / Omland T., Aakvaag A., Bonarjee V. et al. //Circulation. – 1996. –Vol. 1 (93). – P. 1963–1969.
14. James S. K. N-terminal pro-brain natriuretic peptide and other risk markers for the separate prediction of mortality and subsequent myocardial infarction in patients with unstable coronary artery disease: a Global Utilization of Strategies To Open occluded arteries (GUSTO)-IV substudy / James S. K., Lindahl B., Siegbahn A. et al. // Circulation. – 2003. – Vol. 108. – P. 275–281.
15. Sun T. Prognostic value of B-type natriuretic peptide in patients with acute coronary syndrome / Sun T., Wang L., Zhang Y. // Arch Med Res. – 2006. – Vol. 37. – P. 502–505.
16. Godkar D. B-type natriuretic peptide (BNP) and proBNP : role of emerging markers to guide therapy and determine prognosis in cardiovascular disorders / Godkar D., Bachu K., Dave B., et al. // Am J Ther. – 2008. – Vol. 15. – P.150–156.
17. Sarullo F. M. Usefulness of NT-pro-BNP in predicting residual myocardial ischemia in patients with ST elevation acute myocardial infarction / Sarullo F. M., Gristina T., Brusca I., et al. // Minerva Cardioangiol. – 2007. – Vol. 55. – P. 149–155.
18. Ogawa A. Difference in elevation of N-terminal pro-BNP and conventional cardiac markers between patients with ST elevation vs non-ST elevation acute coronary syndrome / Ogawa A., Seino Y., Yamashita T. et al. // Circ J. – 2006. – Vol. 70. – P. 1372–1378.
19. Jernberg T. NT-proBNP in unstable coronary artery disease-experiences from the FAST, GUSTO IV and FRISC II trials / Jernberg T., James S., Lindahl B., Stridsberg M., Venge P., Wallentin L. //Eur. J. Heart. Fail. – 2004. – Vol. 15, № 6 (3). – P. 319–325.
How to Cite
Kopytsya, M. P., Tytarenko, N. V., Bila, N. V., & Oparin, O. L. (1). PROGNOSTIC VALUE NT PRO-BNP IN PATIENTS WITH ACS. The Journal of V. N. Karazin Kharkiv National University, Series "Medicine", (21), 52-60. Retrieved from https://periodicals.karazin.ua/medicine/article/view/6896
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