ІSCHEMIC POSTCONDITIONING
Keywords:
ischemic postconditioning
Abstract
Nowadays theraputical strategy of acute myocardial infarction includes both repefusion methods and treatment of consequences of blood flow restoring. This review presents recent data of literature on one of endogenous cardioprotection mechanisms, that preserves myocardium from ischemic and reperfusion damage ― ischemic postconditioning. Separately we marked at the history of investigation of this question. We examined processes, underlying this mechanism, triggers, that initiate it’s launch and its clinical perspectives.Downloads
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References
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2. Ambrosio G. Reperfusion injury : experimental evidence and clinical implications / G. Ambrosio, I. Tritto // Am Heart J. ― 1999. ― Vol. 138. ― Р. 69―75.
3. Rezkalla S. H. Preconditioning in humans / S. H. Rezkalla, R. A. Kloner // Heart Fail Rev. ― 2007. ― Vol. 1 (3―4). ― Р. 201―206.
4. Downey J. M. Ischemic preconditioning : Nature’s own cardioprotective intervention / J. M. Downey // Trends in Cardiovascular Medicine. ― 1992. ― Vol. 2. ― P. 170―176.
5. Downey J. M. Acetylcholine, Bradykinin, Opioids, and Phenylephrine, but not Adenosine, Trigger Preconditioning by Generating Free Radicals and Opening Mitochondrial KATP Channels / J. M. Downey // Circulation Research. ― 2001. ― Vol. 89. ― P. 273―278.
6. Kloner R. A. Previous angina alters in-hospital outcome in TIMI 4. A clinical correlate to preconditioning? / R. A. Kloner // Circulation. ― 1995. ― Vol. 92. ― P. 1064―1065.
7. Kloner R. A. and the TIMI-9B Investigators. Prospective temporal analysis of the onset of preinfarction angina versus outcome : an ancillary study in TIMI-9B / R. A. Kloner // Circulation. ― 1998. ― Vol. 97. ― P. 1042―1045.
8. Kloner R. A. Ischemic preconditioning and preinfarction angina in the clinical arena / R. A. Kloner // Nat Clin Pract Cardiovasc Med. ― 2004. ― Vol. 1. ― P. 96―102.
9. Kloner R. A. Preinfarct angina and exercise : yet another reason to stay physically active / R. A. Kloner // J Am Coll Cardiol. ― 2001. ― Vol. 38. ― P. 1366―1368.
10. Zhao Z. Q. Inhibition of myocardial injury by ischemic postconditioning during reperfusion : comparison with ischemic preconditioning / Z. Q. Zhao // Am J Physiol Heart Circ Physiol. ― 2003. ― Vol. 285. ― P. 579―584.
11. Couvreur N. Differential effects of postconditioning on myocardial stunning and infarction: a study in conscious dogs and anesthetized rabbits / N. Couvreur // AJP ― Heart. ― 2006. ― Vol. 291. ― P. 1345―1350.
12. Piper H. Bringing preconditioning and postconditioning into focus / H. Piper // Cardiovascular Research. ― 2006. ― Vol. 70. ― P. 167―169.
13. Kloner R. A. Preconditioning, postconditioning and their application to clinical cardiology / R. A. Kloner // Cardiovascular Research. ― 2006. ― Vol. 70. ― P. 297―307.
14. Kaljusto M. L. Postconditioning in rats and mice / M. L. Kaljusto // Scand Cardiovasc J. ― 2006. ― Vol. 70. ― P. 334―341.
15. Kin H. Postconditioning attenuates myocardial ischemia-reperfusion injury by inhibiting events in the early minutes of reperfusion / H. Kin // Cardiovasc Res. ― 2004. ― Vol. 62. ― P. 74―85.
16. Zhao Z. Q. Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning / Z. Q. Zhao // Am J Physiol (Heart Circ Physiol). ― 2003. ― Vol. 285. ― P. 585―588.
17. Hausenloy D. J. Reperfusion injury salvage kinase signaling : taking a RISK for cardioprotection / D. J. Hausenloy // Heart Fail Rev. ― 2007. ― Vol. 12. ― P. 217―234.
18. Inserte J. Ischemic preconditioning attenuates calpain-mediated degradation of structural proteins through a protein kinase A-dependent mechanism / J. Inserte // Cardiovasc Res. ― 2004. ― Vol. 64. ― P. 105―114.
19. Hausenloy D. J. Survival kinases in ischemic preconditioning and postconditioning / D. J. Hausenloy // Cardiovasc Res. ― 2006. ― Vol. 70. ― P. 240―253.
20. Gross G. J. Opioids and myocardial reperfusion injury / G. J. Gross, J. N. Peart // Arch Mal Coeur Vaiss. ― 2007. ― Vol. 100. ― P. 231―237.
21. Ma X. J. Effect of postconditioning on coronary blood flow velocity and endothelial function in patients with acute myocardial infarction / X. J. Ma, X. H. Zhang, C. M. Li // Scand Cardiovasc J. ― 2006. ― Vol. 40. ― P. 327―333.
22. Inagaki K. Additive protection of the ischemic heart ex vivo by combined treatment with protein kinase C inhibitor and epsilon-protein kinase C activator / K. Inagaki // Circulation. ― 2003. ― Vol. 108. ― P. 869―875.
23. Inagaki K. Inhibition of protein kinase C protects against reperfusion injury of the ischemic heart in vivo / K. Inagaki // Circulation. ― 2003. ― Vol. 108. ― P. 2304―2307.
24. Bright R. Protein kinase C mediates cerebral reperfusion injury in vivo / R. Bright // J Neurosci. ― 2004. ― Vol. 24. ― P. 6880―6888.
25. Ivanes F. Postconditioning in Acute Myocardial Infarction Patients / F. Ivanes [et al.] // Antioxidants & Redox Signaling. ― 2011. ― Vol. 14. ― P. 811―820.
26. Kaljusto M. Postconditioning in mouse hearts is inhibited by blocking the reverse mode of the sodium-calcium exchanger / M. Kaljusto // Interact CardioVasc Thorac Surg. ― 2010. ― Vol. 10. ― P. 743―748.
27. Bouwman R. A. Cardioprotection via activation of protein kinase C-delta depends on modulation of the reverse mode of the Na+/Ca2+ exchanger / R. A. Bouwman [et al.] // Circulation. ― 2006. ― Vol. 114. ― P. 226―232.
28. Schafer C. Role of the reverse mode of the Na+/Ca2+ exchanger in reoxygenation-induced cardiomyocyte injury / C. Schafer [et al.] // Cardiovasc Res. ― 2001. ― Vol. 51. ― P. 241―250.
29. Мойбенко О. О. Особливості клітинної смерті кардіоміоцитів при аноксії-реоксигенації / [О. О. Мойбенко, В. Є. Досенко, В. С. Нагибін, Л. В. Тумановська] // Клінічна та експериментальна патологія. ― 2004. ― № 2. ― С. 30―32.
30. Zhao J. Different effects of postconditioning on myocardial no-reflow in the normal and hypercholesterolemic mini-swines / J. Zhao // Microvascular Research. ― 2007. ― Vol. 73. ― P. 137―142.
31. Dow J. The Mechanism by Which Ischemic Postconditioning Reduces Reperfusion Arrhythmias in Rats Remains Elusive / J. Dow // J Cardiovasc Pharmacol Ther. ― 2009. ― Vol. 14. ― P. 99―103.
32. Kloner R. A. Postconditioning markedly attenuates ventricular arrhythmias after ischemia-reperfusion / R. A. Kloner // J Cardiovasc Pharmacol Ther. ― 2006. ― Vol. 11. ― P. 55―63.
33. Sasaki H. Brief Ischemia-Reperfusion Performed After Prolonged Ischemia (Ischemic Postconditioning) Can Terminate Reperfusion Arrhythmias With no Reduction of Cardiac Function in Rats / H. Sasaki // International Heart Journal. ― 2007. ― Vol. 48. ― P. 205―213.
34. Treiman M. Ischemic postconditioning : a clinical perspective / M. Treiman // Interventional Cardiology. ― 2010. ― Vol. 2. ― P. 579―589.
35. Tsang A. Myocardial postconditioning : reperfusion injury revisited / A. Tsang // AJP ― Heart. ― 2005. ― Vol. 289. ― P. 2―7.
36. Baxter G. F. Reperfusion and calculated RISKs : pharmacological postconditioning of human myocardium / G. F. Baxter // British Journal of Pharmacology. ― 2008. ― Vol. 153. ― P. 1―3.
37. Que L. Glucagon-like peptide-1 and the exenatide analogue AC3174 improve cardiac function, cardiac remodeling, and survival in rats with chronic heart failure / L. Que // Cardiovasc Diabetol. ― 2010. ― Vol. 9. ― P. 76.
38. Pagliaro P. Cardioprotective Pathways During Reperfusion : Focus on Redox Signaling and Other Modalities of Cell Signaling / P. Pagliaro [et al.] //Antioxidants & Redox Signaling. ― 2011. ― Vol. 14. ― P. 833―850.
39. Staat P. et al. Postconditioning the human heart / P. Staat [et al.] // Circulation. ― 2005. ― Vol. 112. ― P. 2143―2148.
40. Tissier R. Pharmacological postconditioning with the phytoestrogen genistein / R. Tissier // J Mol Cell Cardiol. ― 2006. ― Vol. 20. ― P. 44―46.
41. Feng J. Isoflurane postconditioning prevents opening of the mitochondrial permeability transition pore through inhibition of glycogen synthase kinase 3beta / J. Feng // Anesthesiology. ― 2005. ― Vol. 103. ― P. 987―995.
42. Andreka G. Remote ischaemic postconditioning protects the heart during acute myocardial infarction in pigs / G. Andreka // Heart. ― 2007. ― Vol. 93. ― P. 749 ClinicalTrials.gov 752.
43. Stavros P. Transient Limb Ischemia Induces Remote Preconditioning and Remote Postconditioning in Humans by a KATP Channel-Dependent Mechanism / P. Stavros // Circulation. ― 2007. ― Vol. 116. ― P. 1386―1395.
44. ClinicalTrials.gov [Електронний ресурс] // Режим доступу до ресурсу : http://www.clinicaltrials. gov/ct2/show/NCT00865722?term=postconditioning&rank=14.
2. Ambrosio G. Reperfusion injury : experimental evidence and clinical implications / G. Ambrosio, I. Tritto // Am Heart J. ― 1999. ― Vol. 138. ― Р. 69―75.
3. Rezkalla S. H. Preconditioning in humans / S. H. Rezkalla, R. A. Kloner // Heart Fail Rev. ― 2007. ― Vol. 1 (3―4). ― Р. 201―206.
4. Downey J. M. Ischemic preconditioning : Nature’s own cardioprotective intervention / J. M. Downey // Trends in Cardiovascular Medicine. ― 1992. ― Vol. 2. ― P. 170―176.
5. Downey J. M. Acetylcholine, Bradykinin, Opioids, and Phenylephrine, but not Adenosine, Trigger Preconditioning by Generating Free Radicals and Opening Mitochondrial KATP Channels / J. M. Downey // Circulation Research. ― 2001. ― Vol. 89. ― P. 273―278.
6. Kloner R. A. Previous angina alters in-hospital outcome in TIMI 4. A clinical correlate to preconditioning? / R. A. Kloner // Circulation. ― 1995. ― Vol. 92. ― P. 1064―1065.
7. Kloner R. A. and the TIMI-9B Investigators. Prospective temporal analysis of the onset of preinfarction angina versus outcome : an ancillary study in TIMI-9B / R. A. Kloner // Circulation. ― 1998. ― Vol. 97. ― P. 1042―1045.
8. Kloner R. A. Ischemic preconditioning and preinfarction angina in the clinical arena / R. A. Kloner // Nat Clin Pract Cardiovasc Med. ― 2004. ― Vol. 1. ― P. 96―102.
9. Kloner R. A. Preinfarct angina and exercise : yet another reason to stay physically active / R. A. Kloner // J Am Coll Cardiol. ― 2001. ― Vol. 38. ― P. 1366―1368.
10. Zhao Z. Q. Inhibition of myocardial injury by ischemic postconditioning during reperfusion : comparison with ischemic preconditioning / Z. Q. Zhao // Am J Physiol Heart Circ Physiol. ― 2003. ― Vol. 285. ― P. 579―584.
11. Couvreur N. Differential effects of postconditioning on myocardial stunning and infarction: a study in conscious dogs and anesthetized rabbits / N. Couvreur // AJP ― Heart. ― 2006. ― Vol. 291. ― P. 1345―1350.
12. Piper H. Bringing preconditioning and postconditioning into focus / H. Piper // Cardiovascular Research. ― 2006. ― Vol. 70. ― P. 167―169.
13. Kloner R. A. Preconditioning, postconditioning and their application to clinical cardiology / R. A. Kloner // Cardiovascular Research. ― 2006. ― Vol. 70. ― P. 297―307.
14. Kaljusto M. L. Postconditioning in rats and mice / M. L. Kaljusto // Scand Cardiovasc J. ― 2006. ― Vol. 70. ― P. 334―341.
15. Kin H. Postconditioning attenuates myocardial ischemia-reperfusion injury by inhibiting events in the early minutes of reperfusion / H. Kin // Cardiovasc Res. ― 2004. ― Vol. 62. ― P. 74―85.
16. Zhao Z. Q. Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning / Z. Q. Zhao // Am J Physiol (Heart Circ Physiol). ― 2003. ― Vol. 285. ― P. 585―588.
17. Hausenloy D. J. Reperfusion injury salvage kinase signaling : taking a RISK for cardioprotection / D. J. Hausenloy // Heart Fail Rev. ― 2007. ― Vol. 12. ― P. 217―234.
18. Inserte J. Ischemic preconditioning attenuates calpain-mediated degradation of structural proteins through a protein kinase A-dependent mechanism / J. Inserte // Cardiovasc Res. ― 2004. ― Vol. 64. ― P. 105―114.
19. Hausenloy D. J. Survival kinases in ischemic preconditioning and postconditioning / D. J. Hausenloy // Cardiovasc Res. ― 2006. ― Vol. 70. ― P. 240―253.
20. Gross G. J. Opioids and myocardial reperfusion injury / G. J. Gross, J. N. Peart // Arch Mal Coeur Vaiss. ― 2007. ― Vol. 100. ― P. 231―237.
21. Ma X. J. Effect of postconditioning on coronary blood flow velocity and endothelial function in patients with acute myocardial infarction / X. J. Ma, X. H. Zhang, C. M. Li // Scand Cardiovasc J. ― 2006. ― Vol. 40. ― P. 327―333.
22. Inagaki K. Additive protection of the ischemic heart ex vivo by combined treatment with protein kinase C inhibitor and epsilon-protein kinase C activator / K. Inagaki // Circulation. ― 2003. ― Vol. 108. ― P. 869―875.
23. Inagaki K. Inhibition of protein kinase C protects against reperfusion injury of the ischemic heart in vivo / K. Inagaki // Circulation. ― 2003. ― Vol. 108. ― P. 2304―2307.
24. Bright R. Protein kinase C mediates cerebral reperfusion injury in vivo / R. Bright // J Neurosci. ― 2004. ― Vol. 24. ― P. 6880―6888.
25. Ivanes F. Postconditioning in Acute Myocardial Infarction Patients / F. Ivanes [et al.] // Antioxidants & Redox Signaling. ― 2011. ― Vol. 14. ― P. 811―820.
26. Kaljusto M. Postconditioning in mouse hearts is inhibited by blocking the reverse mode of the sodium-calcium exchanger / M. Kaljusto // Interact CardioVasc Thorac Surg. ― 2010. ― Vol. 10. ― P. 743―748.
27. Bouwman R. A. Cardioprotection via activation of protein kinase C-delta depends on modulation of the reverse mode of the Na+/Ca2+ exchanger / R. A. Bouwman [et al.] // Circulation. ― 2006. ― Vol. 114. ― P. 226―232.
28. Schafer C. Role of the reverse mode of the Na+/Ca2+ exchanger in reoxygenation-induced cardiomyocyte injury / C. Schafer [et al.] // Cardiovasc Res. ― 2001. ― Vol. 51. ― P. 241―250.
29. Мойбенко О. О. Особливості клітинної смерті кардіоміоцитів при аноксії-реоксигенації / [О. О. Мойбенко, В. Є. Досенко, В. С. Нагибін, Л. В. Тумановська] // Клінічна та експериментальна патологія. ― 2004. ― № 2. ― С. 30―32.
30. Zhao J. Different effects of postconditioning on myocardial no-reflow in the normal and hypercholesterolemic mini-swines / J. Zhao // Microvascular Research. ― 2007. ― Vol. 73. ― P. 137―142.
31. Dow J. The Mechanism by Which Ischemic Postconditioning Reduces Reperfusion Arrhythmias in Rats Remains Elusive / J. Dow // J Cardiovasc Pharmacol Ther. ― 2009. ― Vol. 14. ― P. 99―103.
32. Kloner R. A. Postconditioning markedly attenuates ventricular arrhythmias after ischemia-reperfusion / R. A. Kloner // J Cardiovasc Pharmacol Ther. ― 2006. ― Vol. 11. ― P. 55―63.
33. Sasaki H. Brief Ischemia-Reperfusion Performed After Prolonged Ischemia (Ischemic Postconditioning) Can Terminate Reperfusion Arrhythmias With no Reduction of Cardiac Function in Rats / H. Sasaki // International Heart Journal. ― 2007. ― Vol. 48. ― P. 205―213.
34. Treiman M. Ischemic postconditioning : a clinical perspective / M. Treiman // Interventional Cardiology. ― 2010. ― Vol. 2. ― P. 579―589.
35. Tsang A. Myocardial postconditioning : reperfusion injury revisited / A. Tsang // AJP ― Heart. ― 2005. ― Vol. 289. ― P. 2―7.
36. Baxter G. F. Reperfusion and calculated RISKs : pharmacological postconditioning of human myocardium / G. F. Baxter // British Journal of Pharmacology. ― 2008. ― Vol. 153. ― P. 1―3.
37. Que L. Glucagon-like peptide-1 and the exenatide analogue AC3174 improve cardiac function, cardiac remodeling, and survival in rats with chronic heart failure / L. Que // Cardiovasc Diabetol. ― 2010. ― Vol. 9. ― P. 76.
38. Pagliaro P. Cardioprotective Pathways During Reperfusion : Focus on Redox Signaling and Other Modalities of Cell Signaling / P. Pagliaro [et al.] //Antioxidants & Redox Signaling. ― 2011. ― Vol. 14. ― P. 833―850.
39. Staat P. et al. Postconditioning the human heart / P. Staat [et al.] // Circulation. ― 2005. ― Vol. 112. ― P. 2143―2148.
40. Tissier R. Pharmacological postconditioning with the phytoestrogen genistein / R. Tissier // J Mol Cell Cardiol. ― 2006. ― Vol. 20. ― P. 44―46.
41. Feng J. Isoflurane postconditioning prevents opening of the mitochondrial permeability transition pore through inhibition of glycogen synthase kinase 3beta / J. Feng // Anesthesiology. ― 2005. ― Vol. 103. ― P. 987―995.
42. Andreka G. Remote ischaemic postconditioning protects the heart during acute myocardial infarction in pigs / G. Andreka // Heart. ― 2007. ― Vol. 93. ― P. 749 ClinicalTrials.gov 752.
43. Stavros P. Transient Limb Ischemia Induces Remote Preconditioning and Remote Postconditioning in Humans by a KATP Channel-Dependent Mechanism / P. Stavros // Circulation. ― 2007. ― Vol. 116. ― P. 1386―1395.
44. ClinicalTrials.gov [Електронний ресурс] // Режим доступу до ресурсу : http://www.clinicaltrials. gov/ct2/show/NCT00865722?term=postconditioning&rank=14.
How to Cite
Vatutin, N. T., Kalinkina, N. V., Bakhteeva, T. D., & Kolesnikov, V. S. (1). ІSCHEMIC POSTCONDITIONING. The Journal of V. N. Karazin Kharkiv National University, Series "Medicine", (22), 68-74. Retrieved from https://periodicals.karazin.ua/medicine/article/view/6880
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