THE ROLE OF IRON IN THE HUMAN ORGANISM
Keywords:
iron metabolism
Abstract
This review presents recent data of literature on the mechanisms of iron absorption in the human organism. Separately we marked factors that can lead to iron deficiency or overload. The methods of optimal pharmacological correction of these states were described.Downloads
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References
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2. Anderson G. Control of iron absorption / G. Anderson // J Gastroenterol Hepatol. — 1996. — Vol. 11. — P. 1030—1032.
3. Zhang A. Iron Homeostasis: Recently identified proteins provide insight into novel control mechanisms / A. Zhang, A. Caroline // J Biol Chem. — 2009. — Vol. 284. — P. 711—715.
4. Shayeghi M. Identification of an intestinal heme transporter / M. Shayeghi, G. Latunde-Dada, J. Oakhill // Cell. — 2005. — Vol. 122. — P. 789—801.
5. Conrad M. Umbreit J. Pathways of iron absorption / M. Conrad, J. Umbreit // Blood Cells Mol Dis. — 2002. — Vol. 29. — P. 336—55.
6. Umbreit J. The ferrireductase paraferritin contains divalent metal transporter as well as mobilferrin / J. Umbreit, M. Conrad, L. Hainsworth // Am J Physiol Gastrointest Liver Physiol. — 2002. — Vol. 282. — P. 534—539.
7. Anderson G. Mechanisms of haem and non-haem iron absorption: lessons from inherited disorders of iron metabolism / G. Anderson, D. Frazer, A. McKie // Biometals. — 2005. — Vol. 18. — P. 339—348.
8. Linder M. Vesicular transport of Fe and interaction with other metal ions in polarized Caco2 Cell monolayers / M. Linder, M. Moriya, A. Whon // Biol. Res. — 2006. — Vol. 39. — P. 143—156.
9. Donovan A. The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis / A. Donovan, C. Lima, J. Pinkus [et al.] // Cell Metab. — 2005. — Vol. 1 (3). — P. 191—200.
10. Yeh K. Iron feeding induces ferroportin 1 and hephaestin migration and interaction in rat duodenal epithelium / K. Yeh, M. Yeh, L. Mims // Am J Physiol Gastrointest Liver Physiol. — 2009. — Vol. 296. — P. 55—65.
11. Sipe D. Binding to cellular receptors results in increased iron release from transferrin at mildly acidic pH / D. Sipe, R. Murphy // J Biol Chem. — 1991. — Vol. 266. — P. 802—807.
12. Bali P. A new role for the transferrin receptor in the release of iron from transferring / P. Bali, O. Zak, P. Aisen // Biochemistry. — 1991. — Vol. 30. — P. 324—328.
13. Adlerova L. Lactoferrin: a review / L. Adlerova, A. Bartoskova, M. Faldyna // Veterinarni Medicina. — 2008. — Vol. 53. — P. 457—468.
14. Artym J. The role of lactoferrin in the iron metabolism. Part I. Effect of lactofferin on intake, transport and iron storage / J. Artym // Postepy Hig Med Dosw. — 2008. — Vol. 62. — P. 599—612.
15. Pantopoulos K. Iron metabolism and the IRE/IRP regulatory system: an update / K. Pantopoulos // Ann N Y Acad Sci. — 2004. — Vol. 12. — P. 1—13.
16. Hudson D. Human hephaestin expression is not limited to enterocytes of the gastrointestinal tract but is also found in the antrum, the enteric nervous system, and pancreatic cells / D. Hudson, S. Curtis, V. Smith // Am J Physiol Gastrointest Liver Physiol. — 2010. — Vol. 298. — P. 425—432.
17. Yang F. Hepcidin expression and iron transport in alveolar macrophages / F. Yang // Am J Physiol Lung Cell Mol Physiol. — 2006. — Vol. 291. — P. 417—425.
18. Nemeth E. IL6 mediates hypoferremia inducing the synthesis of the iron regulatory hormone hepcidin / Е. Nemeth, S. Rivera, V. J. Gabajan // J. Clin. Inv. — 2004. — Vol. 113 (9). — Р. 1271—1276.
19. Лубянова И. Современные представления о метаболизме железа с позиции профпатолога / И. Лубянова // Актуальные проблемы транспортной медицины. — 2010. — № 2. — C. 47—57.
20. Giannetti A. Mechanism for multiple ligand recognition by the human transferrin receptor / A. Giannetti, P. Snow, O. Zak // PLoS Biol. — 2003. — Vol. 3. — P. 51.
21. Fleming R. Transferrin receptor 2: Continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis / R. Fleming, M. Migas, C. Holden // PNAS. — 2000. — Vol. 97. — P. 2214—2219.
22. Clark S. Iron Deficiency Anemia / S. Clark // Nutr Clin Pract. — 2008. — Vol. 23. — P. 128—141.
23. Новик А. А., Богданов А. Н. Анемии (от А до Я) руководство для врачей / Под ред. акад. Ю. Л. Шевченко. — СПб : Нева, 2004. — 320 с., ил.
24. Agrawal S. Anemia in rheumatoid arthritis: high prevalence of iron-deficiency anemia in Indian patients / S. Agrawal, R. Misra, A. Agrawal // Rheumatol Int. — 2006. — Vol. 26 (12). — P. 1091—1095.
25. Tandra M. Iron deficiency in rheumatoid arthritic patients especially with in the middle age / M. Tandra, A. Srivastava // International Journal of Systems Biology. — 2010. — Vol. 2, Is. 1. — P. 1—5.
26. Калинкина Н. В. Особенности течения ревматоидного артрита у пациентов со сниженным уровнем гемоглобина / Н. В. Калинкина, А. С. Смирнова, Н. Т. Ватутин // Український ревматологічний журнал. — 2010. — № 42. — С. 34—42.
27. Lai L. Н. Nonsteroid anti-inflammatory drug-induced gastroduodenal injury / L. Н. Lai, F. К. Chan // Curr Opin Gastroenterol. — 2009. — Vol. 25 (6). — P. 544—548.
28. Filaretova L. From gastroprotective to proulcerogenic action of glucocorticoids on the gastric mucosa / [L. Filaretova, O. Morozova, T. Bagaeva, T. Podvigina] // J Physiol Pharmacol. — 2009. — Suppl. 7. — P. 79—86.
29. Fijlstra M. Lactose maldigestion during methotrexate-induced gastrointestinal mucositis in a rat model / M. Fijlstra, E. Rings, H. Verkade [et al.] // Am J Physiol Gastrointest Liver Physiol. — 2011. — Vol. 300 (2). — P. 283—291.
30. Parker B. A case of rheumatoid vasculitis involving the gastrointestinal tract inearly disease / B. Parker, C. Chattopadhyay // Rheumatology. — 2007. — Vol. 46. — P. 1737—1738.
31. Huang H. Multivitamin/mineral supplements and prevention of chronic disease: executive // H. Huang, B. Caballero, S. Chang // Am J Clin Nutr. — 2007. — Vol. 85. — P. 265—268.
32. Duntas L. Incidence of sideropenia and effects of iron repletion treatment in women with subclinical hypothyroidism / L. Duntas, L. Papanastasiou, E. Mantzou // Exp Clin Endocrinol Diabetes. — 1999. — Vol. 107. — P. 356—360.
33. Маньковский Б. Необходимость коррекции анемии для управления сахарным диабетом / Б. Маньковский // Здоров’я України. — 2007. — № 10. — С. 29.
34. Thomas М. Functional erythropoietin deficiency in patients with Type 2 diabetes and anaemia / М. Thomas, С. Tsalamandris, R. Macisaac // Diabet Med. — 2006. — Vol. 23. — Р. 502—509.
35. Tarim O. Effects of iron deficiency anemia on hemoglobin A1c in type 1 diabetes mellitus / O. Tarim, A. Küçükerdoğan, U. Günay // Pediatr Int. — 1999. — Vol. 41. — P. 357—362.
36. Semba R. High prevalence of iron deficiency and anemia among female injection drug users with and without HIV infection / R. Semba, N. Shah, S. Strathdee, D. Vlahov // J Acquir Immune Defic Syndr. — 2002. — Vol. 29. — P. 142—144.
37. Salwa T. Role of Hepcidin in Anemia of Chronic Hepatitis C Patients / S. Toima, S. Abeya, M. Mona // Journal of American Science. — 2010. — Vol. 12. — P. 145—154.
38. Robertson K. Assessment of iron status and the role for iron-replacement therapy in anaemic cancer patients under the care of a specialist palliative care unit / K. Robertson, S. Hutchison // Palliat Med. — 2009. — Vol. 23. — P. 406—409.
39. Park S. Estimation of iron deficiency anemia prevalence in colorectal cancer patients / S. Park, K. Hicks, R. Nisenbaum [et al.] // Gastrointestinal Cancers Symposium. General Poster Session. — 2010. —Abstract 514.
40. Prá D. A possible link between iron deficiency and gastrointestinal carcinogenesis / D. Prá // Nutr Cancer. — 2009. — Vol. 61. — P. 415—426.
41. Frassineii-Gunderson E. Iron stores in users of oralcontraceptive agents / E. Frassineii-Gunderson // The American Journal of Clinical Nutrition. — 1985. — Vol. 41. — P. 703—712.
42. Goddard A. Guidelines for the management of iron deficiency anaemia / A. Goddard, A. McIntyre, B. Scott // Gut. — 2000. — Vol. 46. — P. 1—5.
43. Jacobs P. Erythrocytes: Better Tolerance of Iron Polymaltose Complex Compared with Ferrous Sulphate in the Treatment of Anaemia / P. Jacobs, L. Wood, A. R. Bird // Hematology. — 2000. — Vol. 5 (1). — Р. 77—83.
44. Bopche A. Ferrous sulfate versus iron polymaltose complex for treatment of iron deficiency anemia in children / A. Bopche, R. Dwivedi, R. Mishra // Indian Pediatr. — 2009. — Vol. 46. — P. 883—885.
45. Mehta B. Iron hydroxide polymaltose-cause of persistent iron deficincy anemia at delivery / B. Mehta // Indian Journal of medical sciences. — 2001. — Vol. 55. — P. 616—620.
46. Liu T. Comparison of a combination ferrous fumarate product and a polysaccharide iron complex as oral treatments of iron deficiency anemia / T. Liu, S. Lin, C. Chang // Int J Hematol. — 2004. — Vol. 80. — P. 416—420.
47. Bring P. Iron overload disorders: treatment options for patients refractory to or intolerant of phlebotomy / P. Bring, N. Partovi, J. Ford // Pharmacotherapy. — 2008. — Vol. 28. — P. 331—342.
48. Drakonaki E. Deferoxamine versus combined therapy for chelating liver, spleen and bone marrow iron in beta-thalassemic patients: a quantitative magnetic resonance imaging study / E. Drakonaki, T. Maris, S. Maragaki // Hemoglobin. — 2010. — Vol. 34. — P. 95—106.
49. Miura Y. Iron Chelation Therapy with Deferasirox Results in Improvement of Liver Enzyme Level in Patients with Iron Overload-Associated Liver Dysfunction / [Y. Miura, Y. Matsui, H. Kaneko, M. Watanabe] // Case Report Med. — 2010. — Vol. 1. — P. 1—3.
2. Anderson G. Control of iron absorption / G. Anderson // J Gastroenterol Hepatol. — 1996. — Vol. 11. — P. 1030—1032.
3. Zhang A. Iron Homeostasis: Recently identified proteins provide insight into novel control mechanisms / A. Zhang, A. Caroline // J Biol Chem. — 2009. — Vol. 284. — P. 711—715.
4. Shayeghi M. Identification of an intestinal heme transporter / M. Shayeghi, G. Latunde-Dada, J. Oakhill // Cell. — 2005. — Vol. 122. — P. 789—801.
5. Conrad M. Umbreit J. Pathways of iron absorption / M. Conrad, J. Umbreit // Blood Cells Mol Dis. — 2002. — Vol. 29. — P. 336—55.
6. Umbreit J. The ferrireductase paraferritin contains divalent metal transporter as well as mobilferrin / J. Umbreit, M. Conrad, L. Hainsworth // Am J Physiol Gastrointest Liver Physiol. — 2002. — Vol. 282. — P. 534—539.
7. Anderson G. Mechanisms of haem and non-haem iron absorption: lessons from inherited disorders of iron metabolism / G. Anderson, D. Frazer, A. McKie // Biometals. — 2005. — Vol. 18. — P. 339—348.
8. Linder M. Vesicular transport of Fe and interaction with other metal ions in polarized Caco2 Cell monolayers / M. Linder, M. Moriya, A. Whon // Biol. Res. — 2006. — Vol. 39. — P. 143—156.
9. Donovan A. The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis / A. Donovan, C. Lima, J. Pinkus [et al.] // Cell Metab. — 2005. — Vol. 1 (3). — P. 191—200.
10. Yeh K. Iron feeding induces ferroportin 1 and hephaestin migration and interaction in rat duodenal epithelium / K. Yeh, M. Yeh, L. Mims // Am J Physiol Gastrointest Liver Physiol. — 2009. — Vol. 296. — P. 55—65.
11. Sipe D. Binding to cellular receptors results in increased iron release from transferrin at mildly acidic pH / D. Sipe, R. Murphy // J Biol Chem. — 1991. — Vol. 266. — P. 802—807.
12. Bali P. A new role for the transferrin receptor in the release of iron from transferring / P. Bali, O. Zak, P. Aisen // Biochemistry. — 1991. — Vol. 30. — P. 324—328.
13. Adlerova L. Lactoferrin: a review / L. Adlerova, A. Bartoskova, M. Faldyna // Veterinarni Medicina. — 2008. — Vol. 53. — P. 457—468.
14. Artym J. The role of lactoferrin in the iron metabolism. Part I. Effect of lactofferin on intake, transport and iron storage / J. Artym // Postepy Hig Med Dosw. — 2008. — Vol. 62. — P. 599—612.
15. Pantopoulos K. Iron metabolism and the IRE/IRP regulatory system: an update / K. Pantopoulos // Ann N Y Acad Sci. — 2004. — Vol. 12. — P. 1—13.
16. Hudson D. Human hephaestin expression is not limited to enterocytes of the gastrointestinal tract but is also found in the antrum, the enteric nervous system, and pancreatic cells / D. Hudson, S. Curtis, V. Smith // Am J Physiol Gastrointest Liver Physiol. — 2010. — Vol. 298. — P. 425—432.
17. Yang F. Hepcidin expression and iron transport in alveolar macrophages / F. Yang // Am J Physiol Lung Cell Mol Physiol. — 2006. — Vol. 291. — P. 417—425.
18. Nemeth E. IL6 mediates hypoferremia inducing the synthesis of the iron regulatory hormone hepcidin / Е. Nemeth, S. Rivera, V. J. Gabajan // J. Clin. Inv. — 2004. — Vol. 113 (9). — Р. 1271—1276.
19. Лубянова И. Современные представления о метаболизме железа с позиции профпатолога / И. Лубянова // Актуальные проблемы транспортной медицины. — 2010. — № 2. — C. 47—57.
20. Giannetti A. Mechanism for multiple ligand recognition by the human transferrin receptor / A. Giannetti, P. Snow, O. Zak // PLoS Biol. — 2003. — Vol. 3. — P. 51.
21. Fleming R. Transferrin receptor 2: Continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis / R. Fleming, M. Migas, C. Holden // PNAS. — 2000. — Vol. 97. — P. 2214—2219.
22. Clark S. Iron Deficiency Anemia / S. Clark // Nutr Clin Pract. — 2008. — Vol. 23. — P. 128—141.
23. Новик А. А., Богданов А. Н. Анемии (от А до Я) руководство для врачей / Под ред. акад. Ю. Л. Шевченко. — СПб : Нева, 2004. — 320 с., ил.
24. Agrawal S. Anemia in rheumatoid arthritis: high prevalence of iron-deficiency anemia in Indian patients / S. Agrawal, R. Misra, A. Agrawal // Rheumatol Int. — 2006. — Vol. 26 (12). — P. 1091—1095.
25. Tandra M. Iron deficiency in rheumatoid arthritic patients especially with in the middle age / M. Tandra, A. Srivastava // International Journal of Systems Biology. — 2010. — Vol. 2, Is. 1. — P. 1—5.
26. Калинкина Н. В. Особенности течения ревматоидного артрита у пациентов со сниженным уровнем гемоглобина / Н. В. Калинкина, А. С. Смирнова, Н. Т. Ватутин // Український ревматологічний журнал. — 2010. — № 42. — С. 34—42.
27. Lai L. Н. Nonsteroid anti-inflammatory drug-induced gastroduodenal injury / L. Н. Lai, F. К. Chan // Curr Opin Gastroenterol. — 2009. — Vol. 25 (6). — P. 544—548.
28. Filaretova L. From gastroprotective to proulcerogenic action of glucocorticoids on the gastric mucosa / [L. Filaretova, O. Morozova, T. Bagaeva, T. Podvigina] // J Physiol Pharmacol. — 2009. — Suppl. 7. — P. 79—86.
29. Fijlstra M. Lactose maldigestion during methotrexate-induced gastrointestinal mucositis in a rat model / M. Fijlstra, E. Rings, H. Verkade [et al.] // Am J Physiol Gastrointest Liver Physiol. — 2011. — Vol. 300 (2). — P. 283—291.
30. Parker B. A case of rheumatoid vasculitis involving the gastrointestinal tract inearly disease / B. Parker, C. Chattopadhyay // Rheumatology. — 2007. — Vol. 46. — P. 1737—1738.
31. Huang H. Multivitamin/mineral supplements and prevention of chronic disease: executive // H. Huang, B. Caballero, S. Chang // Am J Clin Nutr. — 2007. — Vol. 85. — P. 265—268.
32. Duntas L. Incidence of sideropenia and effects of iron repletion treatment in women with subclinical hypothyroidism / L. Duntas, L. Papanastasiou, E. Mantzou // Exp Clin Endocrinol Diabetes. — 1999. — Vol. 107. — P. 356—360.
33. Маньковский Б. Необходимость коррекции анемии для управления сахарным диабетом / Б. Маньковский // Здоров’я України. — 2007. — № 10. — С. 29.
34. Thomas М. Functional erythropoietin deficiency in patients with Type 2 diabetes and anaemia / М. Thomas, С. Tsalamandris, R. Macisaac // Diabet Med. — 2006. — Vol. 23. — Р. 502—509.
35. Tarim O. Effects of iron deficiency anemia on hemoglobin A1c in type 1 diabetes mellitus / O. Tarim, A. Küçükerdoğan, U. Günay // Pediatr Int. — 1999. — Vol. 41. — P. 357—362.
36. Semba R. High prevalence of iron deficiency and anemia among female injection drug users with and without HIV infection / R. Semba, N. Shah, S. Strathdee, D. Vlahov // J Acquir Immune Defic Syndr. — 2002. — Vol. 29. — P. 142—144.
37. Salwa T. Role of Hepcidin in Anemia of Chronic Hepatitis C Patients / S. Toima, S. Abeya, M. Mona // Journal of American Science. — 2010. — Vol. 12. — P. 145—154.
38. Robertson K. Assessment of iron status and the role for iron-replacement therapy in anaemic cancer patients under the care of a specialist palliative care unit / K. Robertson, S. Hutchison // Palliat Med. — 2009. — Vol. 23. — P. 406—409.
39. Park S. Estimation of iron deficiency anemia prevalence in colorectal cancer patients / S. Park, K. Hicks, R. Nisenbaum [et al.] // Gastrointestinal Cancers Symposium. General Poster Session. — 2010. —Abstract 514.
40. Prá D. A possible link between iron deficiency and gastrointestinal carcinogenesis / D. Prá // Nutr Cancer. — 2009. — Vol. 61. — P. 415—426.
41. Frassineii-Gunderson E. Iron stores in users of oralcontraceptive agents / E. Frassineii-Gunderson // The American Journal of Clinical Nutrition. — 1985. — Vol. 41. — P. 703—712.
42. Goddard A. Guidelines for the management of iron deficiency anaemia / A. Goddard, A. McIntyre, B. Scott // Gut. — 2000. — Vol. 46. — P. 1—5.
43. Jacobs P. Erythrocytes: Better Tolerance of Iron Polymaltose Complex Compared with Ferrous Sulphate in the Treatment of Anaemia / P. Jacobs, L. Wood, A. R. Bird // Hematology. — 2000. — Vol. 5 (1). — Р. 77—83.
44. Bopche A. Ferrous sulfate versus iron polymaltose complex for treatment of iron deficiency anemia in children / A. Bopche, R. Dwivedi, R. Mishra // Indian Pediatr. — 2009. — Vol. 46. — P. 883—885.
45. Mehta B. Iron hydroxide polymaltose-cause of persistent iron deficincy anemia at delivery / B. Mehta // Indian Journal of medical sciences. — 2001. — Vol. 55. — P. 616—620.
46. Liu T. Comparison of a combination ferrous fumarate product and a polysaccharide iron complex as oral treatments of iron deficiency anemia / T. Liu, S. Lin, C. Chang // Int J Hematol. — 2004. — Vol. 80. — P. 416—420.
47. Bring P. Iron overload disorders: treatment options for patients refractory to or intolerant of phlebotomy / P. Bring, N. Partovi, J. Ford // Pharmacotherapy. — 2008. — Vol. 28. — P. 331—342.
48. Drakonaki E. Deferoxamine versus combined therapy for chelating liver, spleen and bone marrow iron in beta-thalassemic patients: a quantitative magnetic resonance imaging study / E. Drakonaki, T. Maris, S. Maragaki // Hemoglobin. — 2010. — Vol. 34. — P. 95—106.
49. Miura Y. Iron Chelation Therapy with Deferasirox Results in Improvement of Liver Enzyme Level in Patients with Iron Overload-Associated Liver Dysfunction / [Y. Miura, Y. Matsui, H. Kaneko, M. Watanabe] // Case Report Med. — 2010. — Vol. 1. — P. 1—3.
How to Cite
Vatutin, M. T., Kalinkina, N. V., Smyrnova, G. S., Kashanska, O. K., & Milner, I. A. (1). THE ROLE OF IRON IN THE HUMAN ORGANISM. The Journal of V. N. Karazin Kharkiv National University, Series "Medicine", (24), 74-80. Retrieved from https://periodicals.karazin.ua/medicine/article/view/6712
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