THE REGULATORY MECHANISMS OF THE UMBILICAL VEIN HEMODYNAMICS: CLINICAL CONCEPT
Keywords:
intrauterine fetal growth restriction, umbilical vein, Doppler, spectral analysis, regulatory mechanisms
Abstract
It was performed the investigation of the umbilical vein blood flow Doppler spectrograms of 85 patients in the term 37–41 week of gestation and 22 persons of them had normal fetal condition. Intrauterine fetal growth restriction was diagnosed in 63 pregnant women. The spectral components of maximum blood flow velocity were defined. In case of physiological pregnancy umbilical vein blood flow was provided with proper myogenic contractile activity with the frequency of 7 Hz. It was also depended on the arterial component associated with fetal heart rate in the range of 2 Hz. It was determined that fetal compromise was associated with an increase of the slow-wave maternal origin processes with a frequency of 0,5 Hz in the umbilical venous hemodynamics regulation and depletion of the proper myogenic activity. The applied approach could improve current concepts of ergo-trophotropic mechanisms of fetal well-being.Downloads
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References
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5. Umbilical venous volume flow and fetal behavioral states in the normally developing fetus / S. M. E. Boito, N. T. C. Ursem, P. C. Struijk [et al.] // Ultrasound Obstet. Gynecol. ― 2004. ― Vol. 23. ― P. 138―142.
6. Waters S. L. Flow in an elastic tube subject to prescribed forcing: a model of umbilical venous flow / S. L. Waters, C. Guiot // J. of Theoretical Medicine. ― 2001. ― Vol. 3. ― P. 287―298.
7. Сократительная активность гладких мышц артерий и вены пуповины человека и способность сыворотки пуповинной крови повышать их α-адренореактивность / [В. И. Циркин, М. Л. Сазанова, Е. Н. Сизова и др.] // Современные наукоемкие технологии. ― 2004. ― № 4. ― С. 9―12.
8. García-Huidobro D. N. Vasomotion in human umbilical and placental veins: role of gap junctions and intracellular calcium reservoirs in their synchronous propagation / [D. N. García-Huidobro, M. T. García-Huidobro, J. P. Huidobro-Toro] // Placenta. ― 2007. ― Vol. 28, № 4. ― P. 328―338.
9. Regulation of human umbilical artery contractility by different serotonin and histamine receptors / [A. J. Santos-Silva, E. Cairra, B. Marques, I. Verde] // Reproductive Sciences. ― Vol. 16, № 12. ― 2009. ― P. 1175―1185.
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11. Spontaneous rhythmic contractions of human placental vessels : is it an evidence for a physiological pacemaker in blood vessels? / [J. P. Huidobro-Toro, R. Gonzalez, J. A. Varas, A. Rahmer et al.] // Rev. Med. Chil. ― 2001. ― Vol. 129, № 10. ― P. 1105―1112.
12. Calcium oscillations induced by ATP in human umbilical cord smooth muscle cells / [F. Meng, W. To, J. Kirkman-Brown et al.] // Journal of Cellular Physiology. ― Vol. 123, Is. 1. ― 2007. ― P. 79―87.
13. Dong Y. L. Cytosolic Ca2+ concentration effect of CGRP on umbilical vein smooth muscle Ca2+ signaling in human fetoplacental vasculature / [Y. L. Dong, S. Vegiraju, Ch. Yallampalli] // Am. J. Physiol. Heart Circ. Physiol. ― 2005. ― Vol. 289. ― P. 960―967.
14. Intracellular Na(+) modulates large conductance Ca(2+)-activated K (+) currents in human umbilical vein endothelial cells / [G. H. Liang, M. Y. Kim, S. Park et al.] // Pflugers Arch. ― 2008. ― Vol. 457, № 1. ― P. 67―75.
15. Mildenberger E. Prostanoids contribute to the oxygen-dependent regulation of vascular tone of human umbilical vein / [E. Mildenberger, G. Siegel, H. T. Versmold] // J. Perinat. Med. ― 2004. ― Vol. 32, № 2. ― P. 149―154.
16. Pharmacological identification of P2X1, P2X4 and P2X7 nucleotide receptors in the smooth muscles of human umbilical cord and chorionic blood vessels / [P. Valdecantos, R. Briones, P. Moya et al.] // Placenta. ― 2003. ― Vol. 24, № 1. ― P. 17―26.
17. Potentiation of in vitro concentric work in mouse fast muscle / [R. W. Grange, R. Vandenboom, J. Xeni, M. E. Houston] // J. Appl. Physiol. ― 1998. ― Vol. 84, № 1. ― P. 236―243.
18. Resch B. E. Application of electric field stimulation for investigations of human placental blood vessels / [B. E. Resch, R. Gaspar, G. Falkay] // Obstet. Gynecol. ― 2003. ― Vol. 101, № 2. ― P. 297―304.
19. Брехман Г. И. Волновые механизмы обмена информацией в обновляемых системах // Системные исследования и управление открытыми системами / Г. И. Брехман. ― Вып. 2. ― Хайфа, 2006. ― С. 87―96.
20. Pitkanen M. DNA and water Memory : comments on Montagnier group’s recent findings / M. Pitkanen // DNA Decipher Journal. ― 2011. ― Vol. 1, Is. 1. ― P. 181―190.
21. Ушакова Г. А. Нейровегетативная регуляция кардиоритма матери и плода при хронической плацентарной недостаточности / [Г. А. Ушакова, Л. Н. Петрич] // Мать и дитя в Кузбассе. ― 2008. ― № 34 (3). ― С. 21―25.
How to Cite
Lakhno, I. V., Barannik, E. A., & Tkachov, A. E. (1). THE REGULATORY MECHANISMS OF THE UMBILICAL VEIN HEMODYNAMICS: CLINICAL CONCEPT. The Journal of V. N. Karazin Kharkiv National University, Series "Medicine", (22), 38-43. Retrieved from https://periodicals.karazin.ua/medicine/article/view/6873
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