Clinical case of delivery of a pregnant woman with large uterine leiomyoma and rehabilitation in the postoperative period

Keywords: uterine leiomyoma, pregnancy, complications, caesarean section, conservative myomectomy, rehabilitation

Abstract

Abstract. Uterine leiomyoma is a benign neoplasm of the smooth muscles of the uterus, which is one of the causes of infertility and miscarriage in women in the modern world. Delivery of pregnant women with large uterine leiomyoma is a current problem, since there is no single and clear opinion regarding the tactics of managing such patients. In the past, most specialists were inclined to perform hysterectomy after cesarean section, as they considered it the safest method of therapy, since myomectomy during cesarean section raised many questions related to complications during surgery and in the postoperative period. This article examines the modern view of specialists and the experience of the authors on organ-preserving tactics for the treatment of large uterine leiomyomas in women during pregnancy and delivery and analyzes rehabilitation in the postpartum period. The aim of the study. The aim of the study was to analyze scientific literature data on the advisability of performing myomectomy during cesarean section and combining the experience of other specialists with our own experience of delivery of pregnant woman with large uterine leiomyoma using a complex of intraoperative preventive measures. Materials and methods. A clinical case of delivery of a pregnant woman with large uterine leiomyoma and rehabilitation in the postoperative period is described. A systematic online study of articles on the topic of myomectomy during cesarean section was conducted. Results and discussion. Data from a significant number of works by other specialists indicate that preliminary substantiation of factors that may complicate surgical intervention (uterine contractility, anatomical localization, number and diameter of fibroids, as well as the presence of large vascular structures), the use of a set of preventive intraoperative measures and modern suture materials can reduce the amount of blood loss and prevent unfavorable postoperative results. Our proposed algorithm of action, including the administration of tranexamic acid before opening the anterior abdominal wall, a long-acting oxytocin agonist and the hemostatic sponge «Surgicel», allows us to minimize the amount of intraoperative bleeding and the risks of uncontrolled bleeding. It should also be noted that the addition of a cesarean section with myomectomy does not affect the course of rehabilitation in the postoperative period. Conclusions. Based on a study of literary sources over the past 10 years and our own research, we can conclude that myomectomy during cesarean section is advisable in the absence of contraindications. A combination of postoperative rehabilitation measures, tactics and techniques of surgical intervention, and prevention of intraoperative blood loss make it possible to ensure high-quality recovery for patients.

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Author Biographies

Iryna Garahulya, Dnipro State Medical University

PhD, Associate Professor of the Department of Obstetrics and Gynecology at Dnipro State Medical University, 9, Volodimira Vernadskoho str., Dnipro, Ukraine, 49044

Tetiana Demchenko, Dnipro State Medical University

PhD, Associate Professor of the Department of Obstetrics and Gynecology at Dnipro State Medical University, 9, Volodimira Vernadskoho str., Dnipro, Ukraine, 49044

Dmytro Khaskhachikh, Dnipro State Medical University

PhD, Associate Professor of the  Department of Obstetrics and Gynecology at Dnipro State Medical University, 9, Volodimira Vernadskoho str., Dnipro, Ukraine, 49044

Tetiana Vasylenko, Dnipro State Medical University

PhD, Assistant Professor of the  Department of Obstetrics and Gynecology at Dnipro State Medical University, 9, Volodimira Vernadskoho str., Dnipro, Ukraine, 49044

Yuliia Nuriieva, KNP «City Clinical Hospital № 6»

intern doctor of obstetrics and gynecology, KNP «City Clinical Hospital № 6», 29, Manuilivskiy str., Dnipro, Ukraine

References

Kwon DH, Song JE, Yoon KR, Lee KY. The safety of cesarean myomectomy in women with large myomas. Obstet Gynecol Sci. 2014 Sep;57(5):367–72. DOI: https://doi.org/10.5468/ogs.2014.57.5.367

Krimou Y, Erraghay S, Guennoun A, Mamouni N, Bouchikhi C, Banani A. Myoma praevia and pregnancy. Pan Afr Med J. 2019 Jul 17;33:216. DOI: https://doi.org/10.11604/pamj.2019.33.216.14898

Milazzo GN, Catalano A, Badia V, Mallozzi M, Caserta D. Myoma and myomectomy: Poor evidence concern in pregnancy. J Obstet Gynaecol Res. 2017 Dec;43(12):1789–1804. DOI: https://doi.org/

1111/jog.13437

Parazzini F, Tozzi L, Bianchi S. Pregnancy outcome and uterine fibroids. Best Pract Res Clin Obstet Gynaecol. 2016 Jul;34:74–84. DOI: https://doi.org/10.1016/j.bpobgyn.2015.11.017

Newsome J, Martin JG, Bercu Z, Shah J, Shekhani H, Peters G. Postpartum Hemorrhage. Tech Vasc Interv Radiol. 2017 Dec;20(4):266–273. DOI: https://doi.org/10.1053/j.tvir.2017.10.007

Zhao R, Wang X, Zou L, Zhang W. Outcomes of Myomectomy at the Time of Cesarean Section among Pregnant Women with Uterine Fibroids: A Retrospective Cohort Study. Biomed Res Int. 2019 Mar 10;2019:7576934. DOI: https://doi.org/10.1155/2019/7576934

Vergani P, Locatelli A, Ghidini A, Andreani M, Sala F, Pezzullo JC. Large uterine leiomyomata and risk of cesarean delivery. Obstet Gynecol. 2007 Feb;109(2 Pt 1):410–4. DOI: https://doi.org/10.1097/

AOG.0000250470.78700.fo

Thiranun Chanterm, Apichart Chittacharoen, NathpongIsrangura Na Ayudhya. Risk factors of emergency peripartum hysterectomy. Thai Journal of Obstetrics and Gynaecology 2015; 23: 96–103.

Song D, Zhang W, Chames MC, Guo J. Myomectomy during cesarean delivery. Int J Gynaecol Obstet. 2013 Jun;121(3):208–13. DOI: https://doi.org/10.1016/j.ijgo.2013.01.021

El-Refaie W, Hassan M, Abdelhafez MS. Myomectomy during cesarean section: A retrospective cohort study. J Gynecol Obstet Hum Reprod. 2020 Aug 26:101900. DOI: https://doi.org/10.1016/

j.jogoh.2020.101900

Omole-Ohonsi A, Taiwo Olayinka H. Emergency peripartum hysterectomy in a developing country. J Obstet Gynaecol Can. 2012 Oct;34(10):954–960. DOI: https://doi.org/10.1016/S1701-2163(16)35409-3

Ludwig PE, Huff TJ, Shanahan MM, Stavas JM. Pregnancy success and outcomes after uterine fibroid embolization: updated review of published literature. Br J Radiol. 2020 Jan;93(1105):20190551. DOI: https://doi.org/10.1259/bjr.20190551

Senturk MB, Polat M, Doğan O, Pulatoğlu Ç, Yardımcı OD, Karakuş R, Tayyar AT. Outcome of Cesarean Myomectomy: Is it a Safe Procedure? Geburtshilfe Frauenheilkd. 2017 Nov;77(11):1200-1206. DOI: https://doi.org/10.1055/s-0043-120918

Chauhan AR. Cesarean Myomectomy: Necessity or Opportunity? J Obstet Gynaecol India. 2018 Dec;68(6):432–436. DOI: https://doi.org/10.1007/s13224-018-1114-8

Davis JL, Ray-Mazumder S, Hobel CJ, Baley K, Sassoon D. Uterine leiomyomas in pregnancy: a prospective study. Obstet Gynecol. 1990 Jan;75(1):41-4. PMID: 2296420.

Roman AS, Tabsh KM. Myomectomy at time of cesarean delivery: a retrospective cohort study. BMC Pregnancy Childbirth. 2004 Jul 16;4(1):14. DOI: https://doi.org/10.1186/1471-2393-4-14

Grube M, Neis F, Brucker SY, Kommoss S, Andress J, Weiss M, Hoffmann S, Taran FA, Krämer B. Uterine Fibroids - Current Trends and Strategies. Surg Technol Int. 2019 May 15;34:257–263. PMID: 30888674.

O' Sullivan R, Abder R. Myomectomy at the time of cesarean delivery. Ir J Med Sci. 2016 Nov;185(4):973-975. DOI: https://doi.org/10.1007/s11845-015-1378-2

Goyal M, Dawood AS, Elbohoty SB, Abbas AM, Singh P, Melana N, Singh S. Cesarean myomectomy in the last ten years; A true shift from contraindication to indication: A systematic review and meta-analysis. Eur J Obstet Gynecol Reprod Biol. 2021 Jan;256:145–157. DOI: https://doi.org/10.1016/

j.ejogrb.2020.11.008

Leanza V, Fichera S, Leanza G, Cannizzaro MA. Huge fibroid (g. 3.000) removed during cesarean section with uterus preservation. A case report. Ann Ital Chir. 2011 Jan-Feb;82(1):75–7. PMID: 21657160.

Ma PC, Juan YC, Wang ID, Chen CH, Liu WM, Jeng CJ. A huge leiomyoma subjected to a myomectomy during a cesarean section. Taiwan J Obstet Gynecol. 2010 Jun;49(2):220-2. DOI: https://doi.org/10.1016/S1028-4559(10)60048-4

Huang YP, Hsu MC, Lee CN, Fan SZ, Chen LK. Myomectomy of a massive uterine myoma during cesarean section under regional anesthesia. Taiwan J Obstet Gynecol. 2015 Apr;54(2):196–7. DOI: https://doi.org/10.1016/j.tjog.2012.07.043

Sparić R, Kadija S, Stefanović A, Spremović Radjenović S, Likić Ladjević I, Popović J, Tinelli A. Cesarean myomectomy in modern obstetrics: More light and fewer shadows. J Obstet Gynaecol Res. 2017 May;43(5):798–804. DOI: https://doi.org/10.1111/jog.13294

Guler AE, Guler ZCD, Kinci MF, Mungan MT. Myomectomy During Cesarean Section: Why Do We Abstain From? J Obstet Gynaecol India. 2020 Apr;70(2):133–137. DOI: https://doi.org/10.1007/s13224-019-01303-6

Published
2023-11-28
How to Cite
Garahulya, I., Demchenko, T., Khaskhachikh, D., Vasylenko, T., & Nuriieva, Y. (2023). Clinical case of delivery of a pregnant woman with large uterine leiomyoma and rehabilitation in the postoperative period. The Journal of V. N. Karazin Kharkiv National University, Series "Medicine", (47), 64-70. https://doi.org/10.26565/2313-6693-2023-47-07