Changes in thyroid hormones in patients with chronic acalculous cholecystitis in  the practice of a family doctor

doi:10.26565/2313-6693-2020-40-13

Kira Vovk MD, PhD, Associate Professor, Department of General Practice-Family Medicine, School of Medicine, V. N. Karazin Kharkiv National University https://orcid.org/0000-0003-2971-0842
Oleksandr Reznichenko MD, PhD, Associate Professor, Department of General Practice-Family Medicine, V. N. Karazin Kharkiv National University, School of Medicine https://orcid.org/0000-0001-8189-7048
Olga Vlasenko MD, PhD, Associate Professor, Department of General Practice-Family Medicine, V. N. Karazin Kharkiv National University, School of Medicine https://orcid.org/0000-0003-4720-4062
Svitlana Gridnieva MD, PhD, Associate Professor, Department of General Practice-Family Medicine, V. N. Karazin Kharkiv National University, School of Medicine https://orcid.org/0000-0002-7498-9574
Hanna Kratenko MD, PhD, Associate Professor, Department of General Practice-Family Medicine, V. N. Karazin Kharkiv National University, School of Medicine https://orcid.org/0000-0001-7019-5593

DOI: https://doi.org/10.26565/2313-6693-2020-40-13

Keywords: chronic acalculous cholecystitis, thyroid gland, hormones

Abstract

Abstract. Among biliary pathology, chronic acalculous cholecystitis (CAC) occupies one of the central places. The important role of the hormonal system in the regulation of the functioning of the biliary tract has been known for a long time, but the specific mechanisms of these influences remained unclear. Based on the results of a comprehensive clinical, laboratory, biochemical and instrumental examination, all patients with chronic acalculous cholecystitis were divided into three groups depending on the variant of impairment of the motor-kinetic function of the gallbladder. The first group consisted of patients with CAC and hypertensive-hyperkinetic gallbladder dyskinesia (group I) – 17 people; the second – patients with CAC with mixed hypotonic-hyperkinetic gallbladder dyskinesia (group II) – 19 people; the third – patients with САС and hypotonic-hypokinetic dyskinesia of gallbladder (III group) – 29 people. The level of free FT₃, FT₄, and thyroid-stimulating hormone (TSH) was determined by the immunofluorescence method using BREAHMS test systems (Henning Berlin GMBH). The disproportion between the thyroid hormones and the quantitative predominance of the inactive form made it possible to identify the relative hypothyroid syndrome in group I patients. The disproportion between the biologically inactive and active forms of thyroid hormones with a quantitative predominance of the inactive form made it possible to judge the presence of a relative hypothyroid syndrome in group II patients. In group III patients, a significantly increased TSH level was revealed, which was a response of the hypothalamic-pituitary system to a decrease in the level of FT₃.

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Author Biographies

Kira Vovk, MD, PhD, Associate Professor, Department of General Practice-Family Medicine, School of Medicine, V. N. Karazin Kharkiv National University

6, Svobody Sq., Kharkiv, Ukraine, 61022

Oleksandr Reznichenko, MD, PhD, Associate Professor, Department of General Practice-Family Medicine, V. N. Karazin Kharkiv National University, School of Medicine

6, Svobody Sq., Kharkiv, Ukraine, 61022

Olga Vlasenko, MD, PhD, Associate Professor, Department of General Practice-Family Medicine, V. N. Karazin Kharkiv National University, School of Medicine

6, Svobody Sq., Kharkiv, Ukraine 61022

Svitlana Gridnieva, MD, PhD, Associate Professor, Department of General Practice-Family Medicine, V. N. Karazin Kharkiv National University, School of Medicine

6, Svobody Sq., Kharkiv, Ukraine, 61022

Hanna Kratenko, MD, PhD, Associate Professor, Department of General Practice-Family Medicine, V. N. Karazin Kharkiv National University, School of Medicine

6, Svobody Sq., Kharkiv, Ukraine, 61022

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