The role of endothelial dysfunction in children with pyelonephritis against fibrylogenesis disorders

doi:10.26565/2313-6693-2019-38-02

Mariana Iskiv junior research associate of the department of Clinical Genetics of Institute of hereditary pathology of the National Academy of Medical Sciences of Ukraine, Assistant Professor Department of Proupedeutics Pediatrics and Medical Genetics of Lviv National Medical University http://orcid.org/0000-0002-7991-685X
Natalia Lukyanenko DM, Professor, Department of Clinical Genetics Institute of hereditary pathology of the National Academy of Medical Sciences of Ukraine http://orcid.org/0000-0003-4847-1488

DOI: https://doi.org/10.26565/2313-6693-2019-38-02

Keywords: children, violations of fibrillogenesis, dysplasia of a connective tissue, clinical and laboratory markers, oxiprolin, collagen, pyelonephritis

Abstract

Annotation: The prevalence of microbial inflammatory diseases of the urinary system, according to epidemiological studies, is 29.0 per 1000 children. Over the past decades, an unfavourable tendency towards an increase in the pediatric population of chronic pathology has been observed, treatment complicated by a significant pathomorphosis of the disease. Aim of the research: analysis of the frequency of birth defects in the development of organs of the urinary system, as a visceral marker of violation of the fibrillogenase, in children with different variants of pyelonephritis. Materials and methods: 148 children with pyelonephritis from 3 to 18 years were examined. According to the results of catamnestic observation, they were divided into 2 groups: I - 92 people, children with pyelonephritis, in which catamnesis was diagnosed 3 or more episodes of recurrence of pyelonephritis in 2 years, II - 56 children with pyelonephritis, in which for 2 years no relapse of the disease was noted. The control group consisted of 65 somatically healthy children of the same age. All children had a routine comprehensive clinical and laboratory examination and clinical and laboratory markers of fibrillogenic disorder (phenotypic signs of undifferentiated connective tissue dysplasia (UCTD), excretion of oxyproline with urine) were established. Results: In children with recurrent pyelonephritis, phenotypic signs of undifferentiated connective tissue dysplasia. For this purpose, the activity of endothelin-1 fraction, alkaline phosphatase and serum creatine phosphokinase, excretion of creatinine and glycosaminoglycans with daily urine in children with pyelonephritis was studied. On average, the level of endothelin-1 in blood plasma in practically all children in group I was significantly higher (1.815±0.03 fmol/l, q=0.92, p≤0.01) more than in the 10th time, than in children with APN (0.179±0.02 fmol/l, q=0.78 p≤0.01) and healthy children (0.077±0.01 fmol/l, q=0.03). Conclusions: In children with recurrent pyelonephritis, compared with the data of children with acute non-recurrent pyelonephritis, phenotypic signs of undifferentiated dysplasia of connective tissue were significantly more marked. Thus, the negative role of UCTD in the course of pyelonephritis in children has been confirmed. It has been shown that UCTD in children with pyelonephritis is manifested not only by phenotypic features, but also by visceral, such as BD US, which leads to the chronization of the process with frequent relapses.

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Author Biographies

Mariana Iskiv, junior research associate of the department of Clinical Genetics of Institute of hereditary pathology of the National Academy of Medical Sciences of Ukraine, Assistant Professor Department of Proupedeutics Pediatrics and Medical Genetics of Lviv National Medical University

31a, Lysenko Street, Lviv,79008

Lviv, 79010, 69, Pekarska Street

Natalia Lukyanenko, DM, Professor, Department of Clinical Genetics Institute of hereditary pathology of the National Academy of Medical Sciences of Ukraine

31a, Lysenko Street, Lviv, 79008, Ukraine

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