Keywords: pattern-recognition receptors, Toll-like receptors, RIG-I-like receptors


The innate immune response to viral pathogens is crucial in mobilizing defensive reactions of an organism during the development of an acute viral infection. Cells of the innate immunity system detect viral antigens due to genetically programmed pattern-recognition receptors (PRRs), which are located either on the cell surface or inside the certain intracellular components. These image-recognizing receptors include Toll-like receptors (TLRs), retinoic acid-inducible gene I-like receptors (RIG-I-like receptors), nucleotide oligomerization domain-like receptors (NOD-like receptors), also known as NACHT, LRR and PYD domains of the protein, and cytosolic DNA sensors. The trigger mechanisms for these receptors are viral proteins, and nucleic acids serve as activators. The presence of PRRs that are responsible for the determination of viral antigens in cellular components allows the cells of innate immunity to recognize a wide range of viral agents that replicate in various cellular structures, and develop an immune response to them. This article summarizes the disparate data presented in modern English literature on the role of PRRs and the associated signaling pathways. Understanding the recognition of viral pathogens required triggering a cascade of cytokine and interferon production provides insights into how viruses activate the signal paths of PRRs and the effect of the interaction of viral antigens and these receptors on the formation of the antiviral immune response.


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Author Biography

K. A. Veklych, V.N. Karazin Kharkiv National University, Kharkiv, Ukraine

Svobody sq., 6, Kharkiv, 61022, Ukraine


Kaisho T., Akira S. Toll-like receptor function and signaling. J Allergy Clin Immunol. 2006; 117:979– 987.

Honda K., Yanai H., Negishi H., Asagiri M., Sato M., Mizutani T., Shimada N., Ohba Y., Takaoka A., Yoshida N., Taniguchi T. IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature. 2005; 434:772–777.

Kurt-Jones E. A., Popova L., Kwinn L., Haynes L. M., Jones L. P., Tripp R. A., Walsh E. E., Freeman M. W., Golenbock D. T., Anderson L. J., Finberg R. W. Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat. Immunol. 2000; 1:398–401.

Awomoyi A. A., Rallabhandi P., Pollin T. I., Lorenz E., Sztein M. B., Boukhvalova M. S., Hemming V. G., Blanco J. C. G., Vogel S. N. Association of TLR4 polymorphisms with symptomatic respiratory syncytial virus infection in high-risk infants and young children. J Immunol. 2007; 179:3171–3177.

Tal G., Mandelberg A., Dalal I., Cesar K., Somekh E., Tal A., Oron A., Itskovich S., Ballin A., Houri S., Beigelman A., Lider O., Rechavi G., Amariglio N. Association between common Toll-like receptor 4 mutations and severe respiratory syncytial virus disease. J Infect. Dis. 2004; 189:2057–2063.

Bowie A. G., Haga I. R. The role of Toll-like receptors in the host response to viruses. Mol. Immunol. 2005; 42:859–867.

Haeberle H. A., Takizawa R., Casola A., Brasier A. R., Dieterich H. J., Van Rooijen N., Gatalica Z., Garofalo R. P. Respiratory syncytial virus-induced activation of nuclear factor-kappaB in the lung involves alveolar macrophages and toll-like receptor 4-dependent pathways. J Infect. Dis. 2002; 186:1199–1206.

Shan N. Shan Nan Chen, Peng Fei Zou, Pin Niean Chen, Peng Fei Zou, Pin Nie. Retinoic acid‐inducible gene I (RIG‐I)‐like receptors (RLRs) in fish: current knowledge and future perspectives. Immunology. 2017 May; 151(1): 16–25.

Yueh-Ming Loo and Michael Gale, Jr. Immune signaling by RIG-I-like receptors. Immunity. 2011 May 27; 34(5): 680–692. Author manuscript.

Annie Bruns, Curt M. Horvath. Activation of RIG-I-like Receptor Signal Transduction. Critical Rewievs in Biochemistry and Molecular Biology. November 2011; 47(2):194–206.

Ling Xu, Dandan Yu, Yu Fan, Li Peng, Yong Wu, Yong-Gang Yao. Loss of RIG-I leads to a functional replacement with MDA5 in the Chinese tree shrew. PNAS, September 27, 2016; vol.113, No. 39, 10950– 10955.

Mingxian Chang, Bertrand Collet, Pin Nie, Katherine Lester, Scott Campbell, Christopher J. Secombes, Jun Zou. Expression and Functional Characterization of the RIG-I-Like Receptors MDA5 and LGP2 in Rainbow Trout (Oncorhynchus mykiss). American Society for Microbiology. Journal of Virology, Aug. 2011, Vol.85, No. 16; 8403–8412.

Run Fang, Qifei Jiang, Zhengfan Jiang. MAVS activates TBK1 and IKKε through TRAFs in NEMO dependent and independent manner. PLoS Pathog. 2017 Nov; 13(11): e1006720.

Alissa M. Pham and Benjamin R. TenOever. The IKK Kinases: Operators of Antiviral Signaling. Viruses. 2010 Jan; 2(1): 55–72.

Hu W. H., Johnson H., Shu H. B. Activation of NF-kappaB by FADD, Casper, and caspase-8. J Biol Chem. 2000 Apr 14;275(15):10838–44.

Shikama Y., Yamada M., Miyashita T. Caspase-8 and caspase-10 activate NF-kappaB through RIP, NIK and IKKalpha kinases. Eur J Immunol. 2003 Jul; 33(7):1998–2006.

Leonid Gitlin, Loralyn Benoit, Christina Song, Marina Cella, Susan Gilfillan, Michael J. Holtzman, Marco Colonna. Melanoma Differentiation-Associated Gene 5 (MDA5) Is Involved in the Innate Immune Response to Paramyxoviridae Infection In Vivo. January 22, 2010,

Paola M. Barral, Devanand Sarkar, Paul B. Fisher. Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: Key regulators of innate immunity. Pharmacol Ther. 2009 Nov; 124 (2): 219–234. Author manuscript.

Ishii K. J., Coban C., Kato H., Takahashi K., Torii Y., Takeshita F., Ludwig H., Sutter G., Suzuki K., Hemmi H., Sato S., Yamamoto M., Uematsu S., Kawai T., Takeuchi O., Akira S. A Toll-like receptorindependent antiviral response induced by double-stranded B-form DNA. Nat. Immunol. 2006; 7:40–48

How to Cite
Veklych, K. (2019). PATTERN-RECOGNIZING RECEPTORS AND THE INNATE IMMUNE RESPONSE TO VIRAL INFECTION. The Journal of V. N. Karazin Kharkiv National University, Series "Medicine", (36), 96-103. Retrieved from