BACTERIAL INVASION AS A KEY FACTOR IN PROGRESSION OF REACTIVE ARTHRITIS ON EXAMPLE OF CLINICAL CASE
Abstract
A clinical case of middle age male diagnosed with reactive arthritis developed on the background of multiple bacterial invasions such as Salmonella enterica, Ureaplasma urealyticum, Mycoplasma hominis, Borrelia burgdorferi sensu lato and characterized by chronic persistent course of the disease with destructive-inflammatory changes in the joints. This case illustrates the influence of bacterial pathogens on the course and the progression of reactive arthritis. In our patient, reactive arthritis was charac-terized by a chronic persistent course with a constant increase in inflammatory markers and destructive-inflammatory changes in the joints.An important role in the progression of reactive arthritis in this patient played multiple bacterial invasions, which were not only a trigger of the onset of the disease, but also maintained a chronicity of the pathological processes.This clinical case is an illustration of the fact that infectious bacterial diseases play a key role in the pathogenesis of reactive arthritis, and repeated bacterial infections affect the course and progression of the disease, which leads to a significant disruption of the functionof the musculoskeletal system.It is important to treat the patient with avoidance of polypharmacy; this goal is achieved by the appointment of several basic drugs and a supportive therapy used in courses.
Downloads
References
Carlin E.M. 2014 European Guideline on the management of sexually acquired reactive arthritis/ E.M. Carlin, J.M. Ziza, A. Keat [et al.] // International Journal of STD & AIDS. – 2014. - Vol. 25 (13). – p. 901–912.
Colmegna I. HLA-B27-Associated Reactive Arthritis: Pathogenetic and Clinical Considerations / I. Colmegna, R. Cuchacovich, L. R. Espinoza // Clinical microbiology reviews. – 2004. - Vol. 17 (2). – p. 348–369.
Hamdulay S. S. When is arthritis reactive? / S. S. Hamdulay, S. J. Glynne, A. Keat // Postgrad Med J. – 2006. – Vol.82 (969). – p. 446–453.
Reactive arthritis. [electronic resource]/ [C. J. Lozada, M. F. Carpintero, R. A. Schwartz] // Medscape. – 2017. – Access to resourse: https://emedicine.medscape.com/article/331347-overview.
Wu I. B. Reiter's syndrome: the classic triad and more. / I. B. Wu, R. A. Schwartz // J Am Acad Dermatol. – 2008. – No. 59 (1). – p. 113–21.
Nomenklatura, klasifіkacіja, kriterії dіagnostiki ta programi lіkuvannja revmatichnih hvorob. / Pod red. V. M. Kovalenko, N. M. Shuba // Kiїv. – 2004. – s. 117–119.
Tuompo R. Reactive arthritis following Salmonella infection: a population-based study. / R. Tuompo, T. Hannu, L. Mattila [et al.] // Scandinavian Journal of Rheumatology. – 2013. – Vol. 42 No. 3. – p. 196–202.
Ekman P. Modification of disease outcome in salmonella-infected patients by HLA–B27 / P. Ekman, J. Kirveskari, K. Granfors // Arthritis & Rheumatism. – 2000. – Vol. 43 No. 7. – p. 1527–1534.
Spas'ka G.O. Reaktivnij artrit: suchasnij poglyad na problem. / G.O. Spas'ka // Ukraїns'kij medichnij chasopis. – 2011. – No. 6 (86). – S. 42–48.
Horowitz S. Ureaplasma urealyticum in Reiter's syndrome. / S. Horowitz, J. Horowitz, D. Taylor-Robinson // The Journal of Rheumatology. – 1994. – No. 21 (5). – p. 877–882.
Butrimiene I. Potential triggering infections of reactive arthritis./ I. Butrimiene, J. Ranceva, A. Griskevicius // Scand J Rheumatol. – 2006. – No.35 (6). – p. 459–462.
Vorushilina I. E. Tetrada priznakov pri bolezni Rejtera: klinicheskoe nablyudenie. / I. E. Vorushilina, M. I. Mazharova, A. V. Odinec // Medicinskij vestnik severnogo kavkaza. – 2011. – No. 2. – p. 88–90.
Bolezn' Rejtera: sovremennye podhody k lecheniyu. [electronic resource] / [G. M. Bondarenko] // Dermatovenerologіya. – 2009. – Access to resourse: https://kiai.com.ua/ru-issue-article-271/Bolezn-Reytera-sovremennye-podhody-k-lecheniyu.
Taylor-Robinson D. The association of Mycoplasma hominis with arthritis. / D. Taylor-Robinson, B. J. Thomas, P. M. Furr [et al.]// Sex Transm Dis. – 1983. – No. 10 (4). – p. 341–344.
Sibilia J. Reactive arthritis or chronic infectious arthritis? / J. Sibilia, F-X. Limbach // Ann Rheum Dis. – 2002. – No. 61. – p. 580–587.
Sukumar Mukherjee Reactive Arthritis: Current Perspectives. / Mukherjee Sukumar, Kar Madhuchanda // Journal, Indian Academy of Clinical Medicine. – 2000. – Vol. 1 No. 3. – p. 233–238.
Weyand Cornelia M. Immune responses to Borrelia burgdorferi in patients with reactive arthritis / Cornelia M. Weyand, Jorg J. Goronzy // Arthritis & Rheumatism. – 1989. – Vol. 32 No. 9. – p. 1057–1064.
The Journal of V. N. Karazin Kharkiv National University, series Medicine has following copyright terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work’s authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal’s published version of the work, with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
