TIME FOR RADICAL CHANGE OF UNIVERSAL MYOCARDIAL INFARCTION DEFINITION HAS ARRIVED YESTERDAY

  • M. I. Yabluchanskiy
  • A. M. Yabluchanskiy
Keywords: myocardial infarction, inflammation

Abstract

In this manuscript, we discuss a previously introduced definition of the myocardial infarction (MI), and propose to redefine it so it is not limited just to “a necrosis in the setting of myocardial ischemia”, which we think is the case only in the deceased individuals that died during the first few hours from the MI onset, but to include a broader description of the acute aseptic coronarogenic inflammation of the cardiac muscle. We suggest that the outcome of the MI to a large extant depends on the synchronization of the necrotic and reparative processes and that their desynchronization ultimately results in the development of MI complications. A better understanding of the MI and the use of appropriate definition is warranted for a development of new therapeutic targets.

Downloads

Download data is not yet available.

References

1. Neutrophil roles in left ventricular remodeling following myocardial infarction. Ma Y, Yabluchanskiy A, Lindsey ML. Fibrogenesis & tissue repair (2013) 3; 6(1):11. doi: 10.1186/1755-1536-6-11.
2. The Joint European Society of Cardiology/American College of Cardiology Committee. Myocardial infarction redefined – A consensus document of the Joint European Society of Cardiology / American College of Cardiology Committee for the redefinition of myocardial infarction. Eur Heart J (2000) 21: 1502–1513; J Am Coll Cardiol 2000; 36: pp. 959–969.
3. Third universal definition of myocardial infarction. Thygesen K., Alpert J.S., Jaffe A.S. et al. Eur Heart J (2012) 33: pp. 2551–67.
4. Thygesen K, Alpert JS, White HD, Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction. Universal definition of myocardial infarction. Eur Heart J (2007) 28: pp. 2525–2538.
5. Yabluchansky N. I. Acute myocardial infarction strategy. (2000) Kharkiv: Osnova, 80 p.
6. Yabluchansky N.I. Types of blood stem cell reactions and outcomes of acute inflammatory processes in terms of myocardial infarction. Problems of Cryoliology (2008) 18: № 2, p. 184.
Published
2017-12-28
How to Cite
Yabluchanskiy, M. I., & Yabluchanskiy, A. M. (2017). TIME FOR RADICAL CHANGE OF UNIVERSAL MYOCARDIAL INFARCTION DEFINITION HAS ARRIVED YESTERDAY. The Journal of V. N. Karazin Kharkiv National University, Series "Medicine", (34), 5-6. Retrieved from https://periodicals.karazin.ua/medicine/article/view/10030
Section
Philosophy of medicine