TIME FOR RADICAL CHANGE OF UNIVERSAL MYOCARDIAL INFARCTION DEFINITION HAS ARRIVED YESTERDAY

  • M. I. Yabluchanskiy V. N. Karazin Kharkiv National University https://orcid.org/0000-0002-4512-6729
  • A. M. Yabluchanskiy University of Oklahoma, Oklahoma, USA
Keywords: myocardial infarction, inflammation

Abstract

In this manuscript, we discuss a previously introduced definition of the myocardial infarction (MI), and propose to redefine it so it is not limited just to “a necrosis in the setting of myocardial ischemia”, which we think is the case only in the deceased individuals that died during the first few hours from the MI onset, but to include a broader description of the acute aseptic coronarogenic inflammation of the cardiac muscle. We suggest that the outcome of the MI to a large extant depends on the synchronization of the necrotic and reparative processes and that their desynchronization ultimately results in the development of MI complications. A better understanding of the MI and the use of appropriate definition is warranted for a development of new therapeutic targets.

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Author Biographies

M. I. Yabluchanskiy, V. N. Karazin Kharkiv National University

Svobody sq., 6, Kharkiv, 61022, Ukraine

A. M. Yabluchanskiy, University of Oklahoma, Oklahoma, USA

660 Parrington Oval, Norman, OK 73019-0390

References

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Published
2017-12-28
How to Cite
Yabluchanskiy, M. I., & Yabluchanskiy, A. M. (2017). TIME FOR RADICAL CHANGE OF UNIVERSAL MYOCARDIAL INFARCTION DEFINITION HAS ARRIVED YESTERDAY. The Journal of V. N. Karazin Kharkiv National University, Series "Medicine", (34), 5-6. https://doi.org/10.26565/2227-6505-2017-34-01