FIBROTIC CHANGES IN PATIENTS WITH CHRONIC HEART FAILURE WITH CARDIAC DYSSYNCHRONY AND ASSOCIATED TYPE 2 DIABETES MELLITUS

  • T. A. Rudenko Kharkiv Medical Academy of Postgraduate Education
  • O. V. Bilchenko Kharkiv Medical Academy of Postgraduate Education
  • M. O. Khvysiuk Kharkiv Medical Academy of Postgraduate Education
  • O. M. Godlevska Kharkiv Medical Academy of Postgraduate Education
  • A. P. Braslavska Kharkiv Medical Academy of Postgraduate Education
Keywords: volume fraction of interstitial collagen, chronic heart failure, cardiac dyssynchrony, Galectin 3, matrix metalloproteinase 1

Abstract

The study of fibrosis markers was carried out on 72 observed patients (mean age (69 ± 10.37) years) with chronic heart failure (CHF) of ischemic genesis with manifestations of cardiac dyssynchrony (CD) and concomitant type 2 diabetes mellitus – Galectin 3 and matrix metalloproteinase 1. All patients were divided into 2 groups, depending on the presence of CD. The CD was evaluated according to a conventional technique, the volume fraction of interstitial collagen was measured using the formula of J. Shirani and co-authors, the levels of Galectin-3 and matrix metalloproteinase 1 – by the enzyme-linked immunoassay according to the manufacturer's instructions. The data were processed using parametric and nonparametric statistics. It was revealed that the level of fibrosis development was higher in the group of patients with CD than in the group without CD. This indicates the dependence of the development of myocardial sites asynchronous reduction with the presence of interstitial collagen development. That further requires the study of the effect of anti-fibrotic, anti-ischemic and hypoglycemic agents on the progression of CD to prevent subsequent myocardial remodeling.

Downloads

Download data is not yet available.

Author Biographies

T. A. Rudenko, Kharkiv Medical Academy of Postgraduate Education

Kharkiv, Ukraine

O. V. Bilchenko, Kharkiv Medical Academy of Postgraduate Education

Kharkiv, Ukraine

M. O. Khvysiuk, Kharkiv Medical Academy of Postgraduate Education

Kharkiv, Ukraine

O. M. Godlevska, Kharkiv Medical Academy of Postgraduate Education

Kharkiv, Ukraine

A. P. Braslavska, Kharkiv Medical Academy of Postgraduate Education

Kharkiv, Ukraine

References

Rudenko T. A. Role of glycaemia level in the development of interstitial collagen in patients with coronary heart disease and type 2 diabetes / T. A. Rudenko // The Journal of V. N. Karazin Kharkiv National University, series Medicine. – 2015. – No. 30. – p. 30–33.

Ozturk D. Association between serum galectin-3 levels and coronary atherosclerosis and plaque burden/structure in patients with type 2 diabetes mellitus / D. Ozturk, O. Celik, S. Satilmis, et al. // Coronary artery disease. – 2015. – Vol. 26. – No. 5. – p. 396–401.

Cuspidi C. Galectin-3 and Hypertensive Heart Disease / C. Cuspidi, M. Tadic, C. Sala // The Journal of Clinical Hypertension. – 2016. – Vol. 18. – No. 6. – p. 503–505.

Tan K. C. B. Galectin-3 is independently associated with progression of nephropathy in type 2 diabetes mellitus / K. C. B. Tan, C. L. Cheung, A. C. H. Lee // Diabetologia. – 2018. – p. 1–8.

Atherton J. J., Bauersachs J. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. – Web Addenda. – 2016.

Gorcsan J. Echocardiography for cardiac resynchronization therapy: recommendations for performance and reporting–a report from the American Society of Echocardiography Dyssynchrony Writing Group endorsed by the Heart Rhythm Society / J. Gorcsan, T. Abraham, D. A. Agler // Journal of the American Society of Echocardiography. – 2008. – Vol. 21. – No. 3. – p. 191–213.

Shirani J. Usefulness of the Electrocar diagram and Echocar diagram in predictingtheamount of inter stitialmyocardialcjllagen in endomyocardial biopsy specimens of patients with chronic heart failure /

J. Shirani, R. Pick, Y. Quo // Am. J. Cardiol. – 1992. – Vol. 69. – P.1502.

Published
2018-06-29
How to Cite
Rudenko, T. A., Bilchenko, O. V., Khvysiuk, M. O., Godlevska, O. M., & Braslavska, A. P. (2018). FIBROTIC CHANGES IN PATIENTS WITH CHRONIC HEART FAILURE WITH CARDIAC DYSSYNCHRONY AND ASSOCIATED TYPE 2 DIABETES MELLITUS. The Journal of V. N. Karazin Kharkiv National University, Series "Medicine", (35), 57-60. https://doi.org/10.26565/2313-6693-2018-35-08