PROGNOSTIC VALUE OF P-SELECTIN IN PATIENTS WITH STABLE ANGINA PECTORIS
Abstract
Coronary artery disease for many years is being the main cause of death in many developed countries. Currently, cardiovascular disease (CVD) plays the main role in the evolution of the total mortality in the world. Most deaths occur as a result of coronary heart disease (more than 300 thousand per year). It is known that chronic inflammation is a marker of global endothelial dysfunction and may be associated with the increased risk of cardiovascular events in patients with coronary artery disease. Nowadays, it is very promising in terms of assessing the prognosis and course of the disease to study P-selectin. The level of P-selectin in patients with stable angina is not associated with the level of hs-CRP, which creates the prerequisites for the personalization of therapeutic goals for reducing the systemic inflammatory response.2. In patients with high P-selectin (upper tertile), significantly more cardiovascular events are observed compared to patients with low P-selectin (lower tertile), which makes it possible to use the P-selectin level to estimate the prognosis in patients with stable angina.3. The data obtained in the study allow in the long term to use a new biomarker of inflammation of P-selectin to estimate the prognosis in patients with stable angina and to personalize therapy of patients with coronary heart disease aimed at reducing the «residual»cardiovascular risk associated with the activation of various mechanisms of the systemic inflammatory response.
Downloads
References
European Society of Cardiology: Cardiovascular Disease Statistics 2017. Atlas Writing Group, Timmis A., Townsend N., Gale C., Grobbee R., Maniadakis N., Flather M., Wilkins E., Wright L., Vos R., Bax J., Blum M., Pinto F., Vardas P. Eur Heart J. – 2017. Nov 27.
Ridker P. M. How Common Is Residual Inflammatory Risk? CircRes. – 2017. Feb 17; 120 (4):617–619.
Ridker P. M. From C-Reactive Protein to Interleukin-6 to Interleukin-1: Moving Upstream To Identify Novel Targets for Atheroprotection. CircRes. – 2016. Jan 8; 118 (1):145–56.
Swirski F. K., Nahrendorf M. Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failure. Science. – 2013. Jan 11; 339 (6116):161–6.
ESC 2013 guidelines on the management of stable coronary artery disease // European Heart Journal. – 2013. – Vol. 34. – P. 2949–3003. URL: http://www.unimarburg. de/fb20/allgprmed/aktuelles/leitlinie.pdf
Tardif J. C., Tanguay J. F., Wright S. R., Duchatelle V., Petroni T., Grégoire J. C., Ibrahim R., Heinonen T. M., Robb S., Bertrand O. F., Cournoyer D., Johnson D., Mann J., Guertin M. C., L'Allier P. L. Effects of the P-selectin antagonist in clacumab on myocardial damage after percutaneous coronary intervention for non-ST-segment elevation myocardial infarction: results of the SELECT-ACS trial. // J Am CollCardiol. – 2013. May 21; 61 (20): 2048–55.
Ridker P. M., Everett B. M., Thuren T., Mac Fadyen J. G., Chang W. H., Ballantyne C., Fonseca F., Nicolau J., Koenig W., Anker S. D., Kastelein J. J. P., Cornel J. H., Pais P., Pella D., Genest J., Cifkova R., Lorenzatti A., Forster T., Kobalava Z., Vida-Simiti L., Flather M., Shimokawa H., Ogawa H., Dellborg M., Rossi P. R. F., Troquay R. P. T., Libby P., Glynn R. J. CANTOS Trial Group. Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease. // N Engl J Med. – 2017. Sep 21; 377 (12): 1119–1131.
Gross P. L. Soluble P-selectin is the smoke, not the fire. Blood. – 2017. Jul 13; 130 (2): 101–102.
Copyright (c) 2018 The Journal of V. N. Karazin Kharkiv National University, series "Medicine"
This work is licensed under a Creative Commons Attribution 4.0 International License.
The Journal of V. N. Karazin Kharkiv National University, series Medicine has following copyright terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work’s authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal’s published version of the work, with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.