Keywords: Epstein-Barr virus, types of immune response, course of the disease


In 321 patients with different forms of EBV infection in the age range from 19 to 57 years (mean age 33,1 ± 11,7 years) different types of immune response were isolated and studied. All participants in the study were divided into groups of comparable sex and age: patients with infectious mononucleosis (n = 138); patients with various forms of chronic EBV infection (n = 183); clinically healthy volunteers (n = 20). During the study all ethical norms were observed in accordance with international and Ukrainian protocols. Clinical xamination of patients and healthy volunteers included examining complaints, an epidemiological history, a history of illness and life, an objective examination, instrumental and laboratory studies in dynamics. Statistical processing of the results of the study was carried out by parametric and nonparametric methods using the program Statistika 6.0, for each variational series, the absolute values (n), the arithmetic mean (M), the mean error of the arithmetic mean (m) were calculated. It was found that patients with different forms of EBV infection have a reliable cytokine imbalance. Four main types of immune response were identified: normoreactive, dissociative, hyporeactive and hyperreactive. The revealed types of immune response testify to inadequate cellular-humoral reactivity of the organism in conditions of prolonged persistence of EBV, which is manifested by a tendency to suppress cell-mediated and enhancing humoral mechanisms of the immune response and is reflected in the clinical and biochemical manifestations of the disease and leads to a protracted undulating course of the disease.


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Author Biography

T. I. Lyadova, V. N. Karazin Kharkiv National University

Svobody sq., 6, Kharkiv, 61022, Ukraine


Vozianova Zh. I. Infectious mononucleosis as a polyethiological disease / Zh. I. Vozianova, A. I. Glay // Modern infections. – 2004. – No. 2. – P. 37–41.

Isakov V. A. Herpesvirus infections of man: a guide for doctors. / V. A. Isakov, E. I. Arkhipova,

D. V. Isakov. – St. Petersburg, 2006. – 303 p.

Cen О. Latent Membrane Protein 2 (LMP2) / О. Cen, R. Longnecker. // Curr Top Microbiol Immunol. – 2015. – No. 391. – P. 151–180.

Fish K. Epstein-Barr virus latent membrane protein 2A enhances MYC-driven cell cycle progression in a mouse model of B lymphoma. / K. Fish, J. Chen, R. Longnecker. // Blood. – 2014. – No. 123. – P. 530–540.

Ketlinskiy S. A. Tsitokiny / S. A. Ketlinskiy, A. S. Simbirtsev. – Sankt-Peterburg: OOO «Foliant», 2008. – 552 s.

Krasnitskaya A. S. Immunologicheskiye aspekty khronicheskogo tonzillita, assotsiirovannogo s virus Epshteyna-Barr infektsiyey / A. S. Krasnitskaya, N. A. Borovskaya. // Fundamental'nyye issledovaniya. – 2012. – S. 299–305.

Uroven' syvorotochnykh tsitokinov pri limfoproliferativnykh zabolevaniyakh / N. P. Domnikova,

E. E. Petrusenko, O. V. Reshetnikov, S. L. Ryzhikova, N. A. Varaksin // Novosti «Vektor-Best». – 2010. – No. 2 (56). – S. 4–7.

How to Cite
Lyadova, T. I. (2017). TYPES OF IMMUNE RESPONSE FOR VARIOUS ESTHTEIN-BARR FORMS OF VIRAL INFECTION. The Journal of V. N. Karazin Kharkiv National University, Series "Medicine", (34), 11-18. https://doi.org/10.26565/2227-6505-2017-34-03