The effect of micellar medium on the protolytic equilibria of domperidone
Abstract
The attempt to determine deprotonation constants for benzimidazolone fragments of the neutral form of domperidone was made in the micellar medium of sodium dodecyl sulfate and cetylpyridinium chloride by pH-metric titration and spectrophotometry. It was found that domperidone is unstable in the alkaline medium in the presence of micelles of surfactants. The scheme of alkaline hydrolysis of domperidone in the micellar medium of ionic surfactants was proposed.
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References
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