Binding of the domperidone by micelles of sodium dodecylsulfate and Brij 35

doi:10.26565/2220-637X-2012-21-13

Victoria V. Varchenko V.N. Karazin Kharkiv National University
A. M. Odnovolova
Alexander P. Boychenko V.N. Karazin Kharkiv National University
Lidiya P. Loginova V.N. Karazin Kharkiv National University

DOI: https://doi.org/10.26565/2220-637X-2012-21-13

Keywords: domperidone, sodium dodecylsulfate, Brij 35, ionization constant, absorption spectrum, fluorescence spectrum, lifetime, binding constant

Abstract

The ionization constants of the domperidone are determined in the presence of the anionic surfactant, sodium dodecylsulfate, and nonionic surfactant, Brij 35. In the medium of the sodium dodecylsulfate the convergence of the values of ionization constants with the increase of the surfactant concentration is observed. The behaviour of ionization constants of the domperidone in the micellar medium of Brij 35 revealed no simple analogy for the influence of water-organic solvents and micellar solutions of nonionic surfactants on the protolytic properties. Spectral properties of domperidone are investigated in the presence of sodium dodecylsulfate and the constant is obtained for binding of the the protolytic form of the domperidone prevalent in a strong-acid medium by the micelles of sodium dodecylsulfate. The signs of charge of protolytic forms of domperidone are determined at different values of pH by the horizontal electrophoresis.

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