Antioxidant activity of piridilgidrazones aromatic aldehydes

doi:10.26565/2220-637X-2013-22-06

V. V. Vinogradov
A. N. Nikilaevsky
E. I. Khizhan

DOI: https://doi.org/10.26565/2220-637X-2013-22-06

Keywords: piridilgidrazon, antioxidant, the stoichiometric ratio of inhibition, the period of induction, the oxidation of the emulsion

Abstract

The kinetic parameters of anti-radical activity of piridilhidrazones aromatic aldehides in initiated oxidation of ethylbenzene have been investigated from chemiluminescence method. The studied antioxidants have considerably great values of constants of speed k₇ in comparison with the ionol. In the conditions of autooxidation of ethylbenzene the efficiency of the studied antioxidants a reduce.

It was found that 3-piridilgidrazon-3,5-dimetil-4- hydroxy benzaldehyde interacts with cumene hydroperoxide. Regularities of inhibiting action of piridilhidrazones in heterogeneous systems are studied. Interaction of piridilhidrazones with НО^• radicals is investigated by a hemilyuminestsentny method in water solution. It is defined that piridilhidrazones show high activity towards НО^• radicals.

At the initiated azodiizobutironitril oxidation emulsion of ethylbenzene : water derivative of piridilhidrazones showed high antioxidant activity. In the presence of hydrophobic deputies in molecules antioxidants, increase the values of log P and increases induction period (τ/τ₀). The inhibition of the initiated oxidation of dispersion phosphatidylcholine, piridilhidrazones show practically twice higher antioxidant activity in comparison with the ionol.

Downloads

Download data is not yet available.

References

Denisov E., Afanas’ev I. Oxidation and Antioxidants in Organic Chemistry and Biology. Boca Raton, FL: Taylor & Francis, 2005.

Дюбченко О.И., Никулина В.В., Марков А.Ф. и др.//Хим.-фарм. журн. 2006. Т. 40. № 5. С. 10.

Cheraskin E. Antioxidants in health and disease. J Am Optom Assoc 1996; 67(1):50–57

Bagchi D, Sen CK, Ray SD, Das DK, Bagchi M, Preuss HG, Vinson JA. Molecular mecha-nisms of cardioprotection by a novel grape seed proanthocyanidin extract. Mutat Res 2003; 523–524:87–97

Органические растворители / Вайсбергер А., Проскауэр Э., Риддик Д.Ж., Тупс Э. - М.: ИЛ., 1958. - 385с.

А.Н. Николаевский, О.П. Книга, Е.И. Хижан, Г.А. Тихонова, В.В. Виноградов, А.И. Хижан // Журн. физ. хим. 2012. Т. 86. № 12. С. 1953-1957.

Шляпинтох В.Я., Карпухин О.Н., Постников Л.М. и др. Хемилюминесцентные методы исследования медленных химических процессов. М.: Наука, 1966. 300с.

Денисов Е.Т., Азатян В.В. Ингибирование цепных реакций. Черноголовка: ИХФЧ РАН, 1979. 286 с.; Васильев Р.Ф., Кънчева В.Д., Федорова Г.Ф. и др. // Кинетика и катализ. 2010. Т. 51. № 4. С. 533

Эмануэль Н. М., Денисов Е. Т., Майзус З. К. Цепные реакции окисления углеводородов в жидкой фазе. - М.: Наука, 1965. - 270 с.

Кнорре Д. Г. О некоторых особенностях действия ингибиторов в цепных реакциях с вырожденным разветвлением при квадратичном обрыве цепей // Журн. физ. химии. - 1955. - Т. 29, №7. - С. 1285-1291